Phase II Clinical Study on the GEMOX Regimen as Second-line Therapy for Advanced Ovarian Cancer

  • Yuan, Shao-Fei (Department of Oncology & Chemoradiotherapy of Rui'an People Hospital) ;
  • Zhang, Lian-Ping (Department of Urology, Second Xiangya Hospital, Central South University) ;
  • Zhu, Lin-Jia (Department of Oncology & Chemoradiotherapy of Rui'an People Hospital) ;
  • Chen, Wen-Jun (Department of Oncology & Chemoradiotherapy of Rui'an People Hospital) ;
  • Zheng, Wei-E (Department of Oncology & Chemoradiotherapy of Rui'an People Hospital) ;
  • Xiong, Jian-Ping (Cancer Center, First Affiliated Hospital of Nanchang Universituy)
  • Published : 2013.06.30


Aim: To investigate the effectiveness and adverse effects of gemcitabine by fixed-dose rate infusion plus oxaliplatin (GEMOX regimen) as second-line therapy for advanced ovarian cancer. Methods: 64 patients with advanced ovarian cancer were divided into an experimental group (44 cases) and a control group (20 cases). The experimental group was treated with continuous intravenous infusion of gemcitabine at 1000 $mg/m^2$ with a fixed-dose rate of 10 $mg/m^2/min$, on days 1 and 8 and oxaliplatin at 100 $mg/m^2$ on day 1, IVGTT, repeated every 3 weeks. The control group was treated with intravenous infusion of gemcitabine at 1000 $mg/m^2$ within 30 min on days 1 and and oxaliplatin at 100 $mg/m^2$ on day 1, IVGTT, again repeated every 3 weeks. CT scans or MRI were used for review every 1-2 cycles. Results: The effective rate in the experimental group was significantly high than control group (43.2% vs 35.0%; P < 0.05), with no obvious difference of hematologic or non-hematologic toxicity between the two groups (P > 0.05). Conclusion: GEMOX regimen is very effective to treat advanced ovarian cancer, with low toxicity, good tolerance and improved life quality in patients.


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