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Impact of Postoperative Chemoradiotherapy and Chemoradiotherapy Alone for Esophageal Cancer in North-West Iran

  • Mirinezhad, Seyed Kazem (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) ;
  • Somi, Mohammad Hossein (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) ;
  • Shirmohamadi, Masoud (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) ;
  • Seyednejad, Farshad (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Jangjoo, Amir Ghasemi (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Ghojazadeh, Morteza (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) ;
  • Mohammadzadeh, Mohammad (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Naseri, Ali Reza (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Nasiri, Behnam (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences)
  • Published : 2013.06.30

Abstract

Background: To investigate the role of surgical treatment for locally advanced esophageal cancer, we compared the outcomes of chemoradiotheroy alone (CRT) to postoperative chemoradiotherapy (S/CRT), using, Regional Radiotherapy Center, database. Materials and Methods: This retrospective study was conducted in North-West of Iran, included of 255 consecutive patients with esophageal cancer. Eligible operable and non-operable, were treated with S/CRT and CRT respectively. Radiotherapy (RT) was delivered at 1.8-2 Gy/day for five consecutive days in a given week. Chemotherapy (CT) consisted of cisplatin and 5-fluorouracil. Results: From March 2006 to March 2011 255 patients: male/female 129/96, median age 68 (35-90), squamous/adeno 213/12, received CRT/S+CRT 166/59, median radiation dose $45{\pm}13.6Gy$, Median survival 13.5 (11-15), overall survival (OS) One/Two/Three 57/21/16%, Died/alive 158/97, Univariate analysis prognostic factors: age/stag/differentiation/dose of RT/fraction/treatment, Multivariate analysis predictor factor: dose of RT/fraction. Conclusions: Although this treatment offers some possibility for improvement of patients with esophageal cancer, there remains a significant need for development of new drug and new therapeutic approaches that can substantially impact survival.

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  1. Feasibility and Efficacy of Concurrent Chemoradiotherapy in Elderly Patients with Esophageal Squamous Cell Carcinoma: a Respective Study of 116 Cases from a Single Institution vol.16, pp.4, 2015, https://doi.org/10.7314/APJCP.2015.16.4.1463