- Volume 14 Issue 6
DOI QR Code
Impact of Postoperative Chemoradiotherapy and Chemoradiotherapy Alone for Esophageal Cancer in North-West Iran
- Mirinezhad, Seyed Kazem (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) ;
- Somi, Mohammad Hossein (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) ;
- Shirmohamadi, Masoud (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) ;
- Seyednejad, Farshad (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
- Jangjoo, Amir Ghasemi (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
- Ghojazadeh, Morteza (Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences) ;
- Mohammadzadeh, Mohammad (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
- Naseri, Ali Reza (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
- Nasiri, Behnam (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences)
- Published : 2013.06.30
Background: To investigate the role of surgical treatment for locally advanced esophageal cancer, we compared the outcomes of chemoradiotheroy alone (CRT) to postoperative chemoradiotherapy (S/CRT), using, Regional Radiotherapy Center, database. Materials and Methods: This retrospective study was conducted in North-West of Iran, included of 255 consecutive patients with esophageal cancer. Eligible operable and non-operable, were treated with S/CRT and CRT respectively. Radiotherapy (RT) was delivered at 1.8-2 Gy/day for five consecutive days in a given week. Chemotherapy (CT) consisted of cisplatin and 5-fluorouracil. Results: From March 2006 to March 2011 255 patients: male/female 129/96, median age 68 (35-90), squamous/adeno 213/12, received CRT/S+CRT 166/59, median radiation dose
Definitive chemo radiotherapy;survival;esophageal cancer;postoperative chemo radiotherapy;Iran
- Aghcheli K, Marjani A, Nasrollahzadeh D, et al (2011). Prognostic factors for esophageal squamous cell carcinoma-a population-based study in Golestan province, Iran, a High Incidence Area. PLoS ONE, 6, 1-7.
- Berger B, Menzel M, Breucha G, et al (2012). Postoperative versus definitive chemoradiation in early-stage anal cancer. Strahlenther Onkol, 188, 558-63 https://doi.org/10.1007/s00066-012-0120-5
- Davies L, Lewis WG, Arnold DT, et al (2010). Prognostic Signiﬁcance of age in the radical treatment of oesophageal cancer with surgery or chemoradiotherapy: a prospective observational cohort study. Clin Oncol, 22, 578-85. https://doi.org/10.1016/j.clon.2010.05.023
- Jemal A, Siegel R, Xu J, Ward E (2011).Cancer statistics, 2010. CA Cancer J Clin, 61, 133-4. https://doi.org/10.3322/caac.20105
- Jun Jiang X, Quan Song M, Ning Xin Y, et al (2012). Endoscopic stenting and concurrent chemoradiotherapy for advanced esophageal cancer: a case-control study. World J Gastroenterology, 18, 1404-9. https://doi.org/10.3748/wjg.v18.i12.1404
- Ling Yeh H, Ping Hsu C, Ching Lin J, et al (2012). A retrospective study of postoperative chemoradiotherapy for locally advanced esophageal squamous cell carcinoma formosan. J Surg, 45, 172-7.
- Malthaner R, Wong R, Spithoff K, et al (2010). Preoperative or postoperative therapy for resectable oesophageal cancer: an updated practice guideline. Clin Oncol, 22, 250-6. https://doi.org/10.1016/j.clon.2010.02.005
- Mirinezhad SK, SomiMH, Ghasemi JA, et al (2012). Survival rate and prognostic factors of esophageal cancer in east Azerbaijan province, north-west of Iran. Asian Pac J Cancer Prev, 13, 3451-4. https://doi.org/10.7314/APJCP.2012.13.7.3451
- Ryool Koo T, Gyun Wu H, Hun Hah J, et al (2012). Definitive radiotherapy versus postoperative radiotherapy for tonsil cancer. Cancer Res Treat, 44, 227-34. https://doi.org/10.4143/crt.2012.44.4.227
- Semrau R, Herzog SL, Vallbohmer D, et al (2012). Prognostic factors in deﬁnitive radiochemotherapy of advanced inoperable esophageal cancer. Dis Esophagus, 25, 545-54. https://doi.org/10.1111/j.1442-2050.2011.01286.x
- Siegel R, Ward E, Brawley O, et al (2011). Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin, 61, 212-36. https://doi.org/10.3322/caac.20121
- Smit JK, Muijs CT, Burgerhof JGM, et al (2012). Survival after deﬁnitive (chemo) radiotherapy in esophageal cancer patients: a population-based Study in the north-east Netherlands. Ann Surg Oncol, 20, 1985-92.
- Yoon HH, Khan M, Shi Q, et al (2010). The prognostic value of clinical and pathologic factors in esophageal adenocarcinoma: a mayo cohort of 796 patients with extended follow-up after surgical resection. Mayo Clin Proc, 85, 1080-9. https://doi.org/10.4065/mcp.2010.0421
- Yuequan J, Shifeng C, Bing Z (2011). Prognostic factors and family history for survival of esophageal squamous cell carcinoma patients after surgery. Ann Thoracic Surg, 90, 908-13.
- Feasibility and Efficacy of Concurrent Chemoradiotherapy in Elderly Patients with Esophageal Squamous Cell Carcinoma: a Respective Study of 116 Cases from a Single Institution vol.16, pp.4, 2015, https://doi.org/10.7314/APJCP.2015.16.4.1463