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Prognostic Significance of α5β1-integrin Expression in Cervical Cancer

  • Wang, Hua-Yi (Department of Oncology, Zhongnan Hospital of Wuhan University) ;
  • Chen, Zhe (Department of Obstetrics and Gynecology, Jingzhou Second People Hospital) ;
  • Wang, Zhu-Hui (Department of Obstetrics and Gynecology, Jingzhou Second People Hospital) ;
  • Wang, Hong (Department of Pathology, Jingzhou Second People Hospital) ;
  • Huang, Li-Ming (Department of Oncology, Zhongnan Hospital of Wuhan University)
  • Published : 2013.06.30

Abstract

The purpose of this study was to evaluate the association of expression of ${\alpha}5{\beta}1$-integrin with clinicopathologic features and prognosis in cervical cancer. Levels of ${\alpha}5{\beta}1$-integrin in normal cervical mucosa and cervical cancer tissue were detected with immunohistochemistry. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. ${\alpha}5{\beta}1$-integrin expression was detected in 84.6% (143/169) cervical cancer samples, significantly different from that in normal cervical mucosa (P < 0.05). Positive expression rates of ${\alpha}5{\beta}1$-integrin in patients with poor histologic differentiation, lymph node metastasis, and recurrence were elevated. Using Kaplan-Meier analysis, a comparison of survival curves of low versus high expression of ${\alpha}5{\beta}1$-integrin revealed a highly significant difference in human cervical cancer cases (P < 0.05), suggesting that overexpression of ${\alpha}5{\beta}1$-integrin is associated with a worse prognosis.The ${\alpha}5{\beta}1$-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of cervical cancer. The current study indicated that ${\alpha}5{\beta}1$-integrin may be an independent prognostic factor for cervical cancer patients.

Keywords

Cervical cancer;${\alpha}5{\beta}1$-integrin;prognosis;survival

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