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Risk Effects of GST Gene Polymorphisms in Patients with Acute Myeloid Leukemia: A Prospective Study

  • Zhou, Lei (Department of Hematology, Shengjing Hospital Affiliated of China Medical University) ;
  • Zhu, Yan-Yun (Department of Internal Medical Oncology, General Hospital of PLA) ;
  • Zhang, Xiao-Dong (Department of Hematology, No.202 Hospital of PLA) ;
  • Li, Yang (Department of Hematology, Shengjing Hospital Affiliated of China Medical University) ;
  • Liu, Zhuo-Gang (Department of Hematology, Shengjing Hospital Affiliated of China Medical University)
  • Published : 2013.06.30

Abstract

Glutathione S-transferase (GST) enzyme levels are associated with risk of many cancers, including hematologic tumours. We here aimed to investigate the relationships between GSTM1, GSTT1 and GSTP1 polymorphisms and the risk of AML. Genotyping of GSTs was based upon duplex polymerase-chain-reactions with the confronting-two-pair primer (PCR-CTPP) method in 163 cases and 204 controls. Individuals carrying null GSTT1 genotype had a 1.64 fold risk of acute leukemia relative to a non-null genotype (P<0.05). A heavy risk was observed in those carrying combination of null genotypes of GSTM1 and GSTT1 and GSTP1 Val allele genotypes when compared with those carrying wild genotypes, with an OR (95% CI) of 3.39 (1.26-9.26) (P<0.05). These findings indicate that genetic variants of GST and especially the GSTT1 gene have a critical function in the development of AML. Our study offers important insights into the molecular etiology of AML.

Keywords

Glutathione S-transferase;polymorphism;acute myeloid leukemia;risk

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