Age Distribution of Breast Cancer from a Thailand Population-Based Cancer Registry

  • Kotepui, Manas (Medical Technology Program, School of Allied Health Sciences and Public Health, Walailak University) ;
  • Chupeerach, Chaowanee (Institute of Nutrition, Mahidol University)
  • Published : 2013.06.30


Background: Breast cancer is a common cancer worldwide. With the establishment of Thailand's population-based cancer registry and availability of complete data from 2002-2011, it is of interest to investigate the epidemiologic and clinic-pathological profiles of breast cancer based on the population-based registry data. Methods: The data of all breast cancer patients in the registry for the period of 2002-2011 were included. All medical records of the patients diagnosed from documents of National Cancer Registry of Thailand were retrieved and the following information abstracted: age, clinical characteristics, and histological variables. Thailand census data for the period of 2002-2011 were used to provide the general population's statistics on age, gender, and other related demographic factors. Results: Over the 10 year-period, 7,711 breast cancer cases were included. The disease incidence under age 40 years was relatively low (4.13/$10^5$) while the incidence in the age groups 40 and older was very high (39.2/$10^5$). The vast majority of breast cancer cases (88.8%) were diagnosed by histology as primary lesions in the breast. The most common of patients with breast cancer (36.4%) had regional lymph node involvement and the most common of histopathology diagnosed in patients (84.2%) was an infiltrating duct carcinoma. Conclusions: This study showed a high incidence of breast cancer in older subjects, and high rate of breast cancer in Thailand. Future studies should explore clinical and molecular disease patterns.


  1. Bielinska B, Gaj P, Kluska A, et al (2013). Association of the BRCA1 promoter polymor-phism rs11655505 with the risk of familial breast and/or ovarian cancer. Fam Cancer, [Epub ahead of print].
  2. Caplan LS, Schoenfeld ER, O'Leary ES, Leske MC (2000). Breast cancer and electromag-netic fields--a review. Ann Epidemiol, 10, 31-44.
  3. Ekpanyaskul C, Khuhaprema T, Wiangnon S, Sangrajrang S (2010). Case-control study of occupational categories and breast cancer risk in Thailand. Asian Pac J Cancer Prev, 11, 793-7.
  4. Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917.
  5. Hauner D, Janni W, Rack B, Hauner H (2011). The effect of overweight and nutrition on prognosis in breast cancer. Dtsch Arztebl Int, 108, 795-801.
  6. Ligibel J (2011). Obesity and breast cancer. Oncology, 25, 994-1000.
  7. Liu X, Lv C, Luan X, Lv M (2013). C282Y polymorphism in the HFE gene is associated with risk of breast cancer. Tumour Biol, [Epub ahead of print].
  8. Luo J, Margolis KL, Wactawski-Wende J, et al (2011). Association of active and passive smoking with risk of breast cancer among postmenopausal women: a prospective co-hort study. BMJ, 342, 1016.
  9. National Cancer Institute (2013). Ministry of Public Health, Bangkok.
  10. National Statistical Office of Thailand (2012). Population from registration record by age group and sex, whole kingdom: 2001-2010. Bangkok.
  11. Peplonska B, Szeszenia-Dabrowska N (2001). Occupational risk factors for breast cancer in the epidemiological studies. Med Prev, 52, 483-95.
  12. Petralia SA, Vena JE, Freudenheim JL, et al (1999). Risk of premenopausal breast cancer in association with occupational exposure to polycyclic aromatic hydrocarbons and ben-zene. Scand J Work Environ Health, 25, 215-21.
  13. Pierce JP, Natarajan L, Caan BJ, et al (2007). Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized trial. JAMA, 298, 289-98.
  14. Ramalhinho AC, Marques J, Fonseca-Moutinho J, Breitenfeld L (2013). Genetic polymor-phims of estrogen receptor alpha-397 PvuII (T>C) and -351 XbaI (A>G) in a portuguese population: prevalence and relation with breast cancer susceptibility. Mol Biol Rep, [Epub ahead of print].
  15. Sriplung H, Sontipong S, Martin N, et al (2005). Cancer incidence in Thailand, 1995-1997. Asian Pac J Cancer Prev, 6, 276-81.
  16. Sriplung H, Wiangnon S, Sontipong S, Sumitsawan Y, Martin N (2006). Cancer incidence trends in Thailand, 1989-2000. Asian Pac J Cancer Prev, 7, 239-44.
  17. Stoll BA (1998). Western diet, early puberty, and breast cancer risk. Breast Cancer Res Treat, 49, 187-93.
  18. Teng Y, Ghoshal P, Ngoka L, Mei Y, Cowell JK (2013). Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility. Carcinogenesis, [Epub ahead of print].

Cited by

  1. Comparison of Male and Female Breast Cancer Incidence and Mortality Trends in Central Serbia vol.14, pp.10, 2013,
  2. Overview of Cancer Registration Research in the Asian Pacific from 2008-2013 vol.14, pp.8, 2013,
  3. SLC35B2 Expression is Associated with a Poor Prognosis of Invasive Ductal Breast Carcinoma vol.15, pp.15, 2014,
  4. Incidence and Mortality of Female Breast Cancer in Jiangsu, China vol.15, pp.6, 2014,
  5. Differences in Incidence, Mortality and Survival of Breast Cancer by Regions and Countries in Asia and Contributing Factors vol.16, pp.7, 2015,
  6. Proanthocyanidin in Red Rice Inhibits MDA-MB-231 Breast Cancer Cell Invasion via the Expression Control of Invasive Proteins vol.38, pp.4, 2015,