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Association of XRCC1 Gene Polymorphisms with Breast Cancer Susceptibility in Saudi Patients

  • Al Mutairi, Fatima Masoud (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) ;
  • Alanazi, Mohammed (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) ;
  • Shalaby, Manal (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) ;
  • Alabdulkarim, Huda A. (The Comprehensive Cancer Center at King Fahad Medical City) ;
  • Pathan, Akbar Ali Khan (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) ;
  • Parine, Narasimha Reddy (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University)
  • Published : 2013.06.30

Abstract

Background: X-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision repair pathway, as a scaffold protein that brings together proteins of the DNA repair complex. XRCC1 is reported to be a candidate influence on cancer risk. The aim of our present study was to assess the association of rs1799782 (Arg194Trp) and rs25487 (Arg399Gln) XRCC1 gene polymorphisms with breast cancer in the Saudi population. Materials and Methods: The two SNP's were analyzed in breast cancer patients and healthy control subjects. Genotypes were determined by TaqMan SNP genotype analysis technique and data were analyzed using Chi-square or t test and logistic regression analysis by SPSS16.0 software. Results and Conclusions: Results showed that rs1799782 significantly increased susceptibility to breast cancer with Arg/Trp, Arg/Trp+Trp/Trp genotypes and at Trp allele overall study. It also increased risk of breast cancer in older age patients (above 48) and with the ER positive category. XRCC1rs25487 (Arg399Gln) did not showed any significant association. In conclusion the XRCC1rs1799782 polymorphism may be involved in the etiology of breast cancer in the Saudi population. Confirmation of our findings in larger populations of different ethnicities is warranted.

Keywords

XRCC1;Saudi population;breast cancer;genetic polymorphism

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