- Volume 14 Issue 6
DOI QR Code
Interactive Effect of Bisphenol A (BPA) Exposure with -22G/C Polymorphism in LOX Gene on the Risk of Osteosarcoma
- Jia, Jie (Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
- Tian, Qing (Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
- Liu, Yong (Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
- Shao, Zeng-Wu (Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
- Yang, Shu-Hua (Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology)
- Published : 2013.06.30
Background: Osteosarcomas have many established risk factors, both genetic and environmental, but by themselves these explain only part of the total cancer incidence. Bisphenol A (BPA) is an environmental estrogen associated with risk of several kinds of tumour. The lysyl oxidase gene (LOX) may also contribute to risk of tumours including osteosarcomas. Here, we investigated possible interactions of BPA and a LOX polymorphism on the risk of osteosarcoma. Method: The present hospital-based case-control study included 106 cancer patients and 112 controls from a Chinese population. Internal burden of BPA exposure was assessed using high-performance liquid chromatography-mass spectrometry (HPLC-MS) method. Genotypes were determined using PCR-RFLP methods. Results: Compared with those in low BPA exposure group, subjects with BPA more than or equal to median value had significant increased risk of osteosarcoma among subjects who carried GC or CC genotypes. A significant interaction with BPA level and the -22G/C polymorphism was observed for osteosarcoma overall, osteosarcoma affecting knee and osteosarcoma affecting hip, as
Osteosarcoma;bisphenol A (BPA);Lysyl oxidase gene (LOX);gene polymorphism;interactive effect
- Bland R (2000). Steroid hormone receptor expression and action in bone. Clin Sci (Lond), 98, 217-40. https://doi.org/10.1042/CS19990252
- Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL (2008). Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol, 2003-2004. Environ Health Perspect, 116, 39-44.
- Caronia D, Patino-Garcia A, Perez-Martinez A, et al (2011). Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy, a pharmacogenetic study. PLoS One, 6, e26091. https://doi.org/10.1371/journal.pone.0026091
- Duan B, Hu X, Zhao H, Qin J, Luo J (2012). The relationship between urinary bisphenol A levels and meningioma in Chinese adults. Int J Clin Oncol, 18, 492-7.
- Ericson U, Sonestedt E, Gullberg B, Olsson H, Wirfalt E (2007). High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort. Am J Clin Nutr, 86, 434-43.
- Eyre DR, Dickson IR, Van Ness K (1988). Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues. Biochem J, 252, 495-500.
- Fernandez SV, Russo J (2010). Estrogen and xenoestrogens in breast cancer. Toxicol Pathol, 38, 110-22. https://doi.org/10.1177/0192623309354108
- Francis DD, Szegda K, Campbell G, Martin WD, Insel TR (2003). Epigenetic sources of behavioral differences in mice. Nat Neurosci, 6, 445-6.
- Hameed M, Dorfman H (2011). Primary malignant bone tumors--recent developments. Semin Diagn Pathol, 28, 86-101. https://doi.org/10.1053/j.semdp.2011.02.002
- Ho SM, Tang WY, Belmonte de Frausto J, Prins GS (2006). Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res, 66, 5624-32. https://doi.org/10.1158/0008-5472.CAN-06-0516
- Juul A (2001). The effects of oestrogens on linear bone growth. Hum Reprod Update, 7, 303-13. https://doi.org/10.1093/humupd/7.3.303
- Knott L, Whitehead CC, Fleming RH, Bailey AJ (1995). Biochemical changes in the collagenous matrix of osteoporotic avian bone. Biochem J, 310, 1045-51.
- Liu Y, Lv B, He Z, et al (2012). Lysyl oxidase polymorphisms and susceptibility to osteosarcoma. PLoS One, 7, e41610. https://doi.org/10.1371/journal.pone.0041610
- Martin JW, Squire JA, Zielenska M (2012). The genetics of osteosarcoma. Sarcoma, 2012, 627254.
- Melzer D, Harries L, Cipelli R, et al (2011). Bisphenol A Exposure is Associated with In-Vivo Estrogenic Gene Expression in Adults. Environ Health Perspect, 119, 1788- 93. https://doi.org/10.1289/ehp.1103809
- Mirabello L, Berndt SI, Seratti GF, et al (2010). Genetic variation at chromosome 8q24 in osteosarcoma cases and controls. Carcinogenesis, 31, 1400-04. https://doi.org/10.1093/carcin/bgq117
- Sandberg AA, Bridge JA (2003). Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors, osteosarcoma and related tumors. Cancer Genet Cytogenet, 145, 1-30. https://doi.org/10.1016/S0165-4608(03)00105-5
- Gemcitabine for the Treatment of Patients with Osteosarcoma vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7159
- Identification and Functional Analysis of Differentially Expressed Genes Related to Metastatic Osteosarcoma vol.15, pp.24, 2015, https://doi.org/10.7314/APJCP.2014.15.24.10797
- Role of five small nucleotide polymorphisms in the VEGF gene on the susceptibility to osteosarcoma and overall survival of patients pp.1792-1082, 2015, https://doi.org/10.3892/ol.2015.3396
- MicroRNA-26a induces osteosarcoma cell growth and metastasis via the Wnt/β-catenin pathway vol.11, pp.2, 2015, https://doi.org/10.3892/ol.2015.4073