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Relationship between Epidermal Growth Factor Receptor Gene Mutations and Clinicopathological Features in Patients with Non-Small Cell Lung Cancer in Western Turkey

  • Unal, Olcun Umit (Department of Medical Oncology, Dokuz Eylul University) ;
  • Oztop, Ilhan (Department of Medical Oncology, Dokuz Eylul University) ;
  • Calibasi, Gizem (Institute of Oncology, Dokuz Eylul University) ;
  • Baskin, Yasemin (Institute of Oncology, Dokuz Eylul University) ;
  • Koca, Dogan (Department of Medical Oncology, Van Training and Research Hospital) ;
  • Demir, Necla (Department of Medical Oncology, Dokuz Eylul University) ;
  • Akman, Tulay (Department of Medical Oncology, Dokuz Eylul University) ;
  • Ellidokuz, Hulya (Institute of Oncology, Dokuz Eylul University) ;
  • Yilmaz, Ahmet Ugur (Department of Medical Oncology, Izmir University Medical Faculty)
  • Published : 2013.06.30

Abstract

Background: To investigate epidermal growth factor receptor (EGFR) gene mutations in patients with non-small cell lung cancer (NSCLC) and to analyze any relationship with clinicopathological features and prognosis. Materials and Methods: EGFR gene exons 18-21 in 48 specimens of paraffin-embedded tumor tissue from NSCLC patients were amplified by PCR, followed by direct sequencing and analysis of links to clinicopathological features and prognosis. Results: EGFR mutations were detected in 18 of 48 (42.6%) patients with NSCLC. There were 9 cases of mutations in exon 20, 7 in exon 19 and 2 in exon 21. Mutations were more frequently observed in women (5/7 pts, 71.4%) than in men (13/41 pts, 31.7%) (p=0.086) and in non-smokers (5/5 pts, 100%) than smokers (13/43 pts, 30.2%). There was negative correlation of EGFR mutations with smoking status (p=0.005). EGFR mutations were more frequently observed with adenocarcinoma histology (13/32 pts, 40.6%) than in other types (5/16 pts, 31.3%) (p=0.527). The patients with EGFR mutations had better survival than those with wild-type EGFR (p=0.08). There was no association of EGFR mutations with metastatic spread. Conclusions: EGFR mutations in NSCLC were here demonstrated more frequently in females, non-smokers and adenocarcinoma histology in the western region of Turkey. Patients with EGFR mutations have a better prognosis.

Keywords

EGFR mutations;non small cell lung cancer;clinical features;Western Turkey

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