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Investigation of the Antioxidant Status in Multiple Myeloma Patients: Effects of Therapy

  • Mehdi, Wesen A. (Department of Chemistry, University of Baghdad) ;
  • Zainulabdeen, Jwan A. (Department of Chemistry, University of Baghdad) ;
  • Mehde, Atheer A. (Department of Acceptable Analysis, Health and Medical Technical College)
  • Published : 2013.06.30

Abstract

Background: Multiple myeloma is a malignant silent incurable plasma cell disorder. The present study aimed to assessed the activation of the oxidative stress pathway in afected patients Materials and Methods: Advanced oxidation protein products (AOPPs), malondialdehyde (MDA), adenosine deaminase (ADA), total antioxidant capacity (TAC) levels, glutathione, ascorbic acid (vitamin C), ${\alpha}$-tocopherol (vitamin E) in addition to related enzymes glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R) and superoxide dismutase (SOD) were analyzed in sixty patients with multiple myeloma before and after one month treatment with induction therapy. Results: The results of the study showed a significant elevation in AOPPs, MDA, ADA levels in patients with multiple myeloma before and after treatment in comparison to healthy control samples In contrast TAC glutathione, vitamin C and E, and the antioxidant enzymes levels were decreased significantly. On comparing samples of MM patients after treatment, there was significant increase of TAC glutathione, vitamin C and E, and the antioxidant enzymes in parallel with decreasing AOPPs, MDA and ADA levels in comparison with samples of patients before treatment. Conclusions: The results indicate oxidative stress and DNA damage activity increase in MM and are alleviated in response to therapy.

Keywords

Multiple myeloma;oxidation byproducts;antioxidants;antioxidant enzymes;total antioxidant capacity

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