DOI QR코드

DOI QR Code

The 2518 A/G Polymorphism in the MCP-1 Gene and Cancer Risk: A Meta-analysis

  • Jia, Liu-Qun (Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University) ;
  • Shen, Yong-Chun (Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University) ;
  • Guo, Shu-Jin (Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University) ;
  • Hu, Qian-Jing (Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University) ;
  • Pang, Cai-Shuang (Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University) ;
  • Wang, Tao (Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University) ;
  • Chen, Lei (Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University) ;
  • Wen, Fu-Qiang (Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University)
  • Published : 2013.06.30

Abstract

Background: The 2518 A/G polymorphism in the MCP-1 gene has been extensively studied for association swith cancer; however, results from replication studies have been inconsistent. The aim of this investigation was to determine links with risk of cancer by meta-analysis. Methods: We searched Pubmed, Embase, CNKI, Weipu and Wanfang databases, covering all case-control studies until March, 2013. Statistical analyses were performed using the Revman 5.0 software. Results: A total of 11 case-control studies met our inclusion criteria, including 1,422 cases and 2,237 controls. The results indicated that the MCP-1 2518 gene polymorphism had no association with cancer risk overall (GG vs.GA+ AA: OR = 0.89, 95%CI = 0.61-1.28, P = 0.52). However, in the subgroup analysis by ethnicity, a decrease of cancer risk was found in Asian populations (GG vs.GA+ AA: OR = 0.79, 95%CI = 0.63-0.99, P = 0.04). Conclusion: This meta-analysis suggested that the 2518A/G polymorphism of MCP-1 gene is associated with risk of cancer among Asian, but not in Caucasian populations.

Keywords

MCP-1;cancer;polymorphism;meta-analysis;ethnicity

References

  1. Attar R, Agachan B, Kuran SB, et al (2010). Association of CCL2 and CCR2 gene variants with endometrial cancer in Turkish women. In Vivo, 24, 243-8.
  2. Balkwill F, Mantovani A (2001). Inflammation and cancer: back to Virchow? Lancet, 357, 539-45. https://doi.org/10.1016/S0140-6736(00)04046-0
  3. Bektas-Kayhan K, Unur M, Boy-Metin Z, Cakmakoglu B (2012). MCP-1 and CCR2 gene variants in oral squamous cell carcinoma. Oral Dis, 18, 55-9. https://doi.org/10.1111/j.1601-0825.2011.01843.x
  4. Chen MK, Yeh KT, Chiou HL, et al (2011). CCR2-64I gene polymorphism increase susceptibility to oral cancer. Oral Oncol, 47, 577-82. https://doi.org/10.1016/j.oraloncology.2011.04.008
  5. Gu H, Ni M, Guo X, et al (2011). The functional polymorphism in monocyte chemoattractant protein-1 gene increases susceptibility to gastric cancer. Med Oncol, 28, S280-5. https://doi.org/10.1007/s12032-010-9748-0
  6. Hanahan D, Weinberg RA (2000). The hallmarks of cancer. Cell, 100, 57-70. https://doi.org/10.1016/S0092-8674(00)81683-9
  7. Kruszyna L, Lianeri M, Rubis B, et al (2011). CCL2 -2518 A/G single nucleotide polymorphism as a risk factor for breast cancer. Mol Biol Rep, 38, 1263-7. https://doi.org/10.1007/s11033-010-0225-9
  8. Kucukgergin C, Isman FK, Cakmakoglu B, Sanli O, Seckin S (2012a). Association of polymorphisms in MCP-1, CCR2, and CCR5 genes with the risk and clinicopathological characteristics of prostate cancer. DNA Cell Biol, 31, 1418-24. https://doi.org/10.1089/dna.2012.1716
  9. Kucukgergin C, Isman FK, Dasdemir S, et al (2012b). The role of chemokine and chemokine receptor gene variants on the susceptibility and clinicopathological characteristics of bladder cancer. Gene, 511, 7-11. https://doi.org/10.1016/j.gene.2012.09.011
  10. Mantovani A, Allavena P, Sica A, Balkwill F (2008). Cancerrelated inflammation. Nature, 454, 436-44. https://doi.org/10.1038/nature07205
  11. Narter KF, Agachan B, Sozen S, Cincin ZB, Isbir T (2010). CCR2-64I is a risk factor for development of bladder cancer. Genet Mol Res, 9, 685-92. https://doi.org/10.4238/vol9-2gmr829
  12. O'Hayre M, Salanga CL, Handel TM, Allen SJ (2008). Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment. Biochem J, 409, 635-49. https://doi.org/10.1042/BJ20071493
  13. Rollins BJ, Walz A, Baggiolini M (1991). Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes. Blood, 78, 1112-6.
  14. Rovin BH, Lu L, Saxena R (1999). A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression. Biochem Biophys Res Commun, 259, 344-8. https://doi.org/10.1006/bbrc.1999.0796
  15. Saenz-Lopez P, Carretero R, Cozar JM, et al (2008). Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer. BMC Cancer, 8, 382. https://doi.org/10.1186/1471-2407-8-382
  16. Shi CL, Yu CH, Zhang Y, et al (2011). Monocyte chemoattractant protein-1 modulates invasion and apoptosis of PC-3M prostate cancer cells via regulating expression of VEGF, MMP9 and caspase-3. Asian Pac J Cancer Prev, 12, 555-9.
  17. Singh V, Srivastava P, Srivastava N, et al (2012). Association of inflammatory chemokine gene CCL2I/D with bladder cancer risk in North Indian population. Mol Biol Rep, 39, 9827-34. https://doi.org/10.1007/s11033-012-1849-8
  18. Vazquez-Lavista LG, Lima G, Gabilondo F, Llorente L (2009). Genetic association of monocyte chemoattractant protein 1 (MCP-1)-2518 polymorphism in Mexican patients with transitional cell carcinoma of the bladder. Urology, 74, 414-8. https://doi.org/10.1016/j.urology.2009.04.016
  19. Wu HH, Lee TH, Tee YT, et al (2013). Relationships of Single Nucleotide Polymorphisms of Monocyte Chemoattractant Protein 1 and Chemokine Receptor 2 With Susceptibility and Clinicopathologic Characteristics of Neoplasia of Uterine Cervix in Taiwan Women. Reprod Sci.
  20. Yang L, Shi GL, Song CX, Xu SF (2010). Relationship between genetic polymorphism of MCP-1 and non-small-cell lung cancer in the Han nationality of North China. Genet Mol Res, 9, 765-71. https://doi.org/10.4238/vol9-2gmr740
  21. Yeh CB, Tsai HT, Chen YC, et al (2010). Genetic polymorphism of CCR2-64I increased the susceptibility of hepatocellular carcinoma. J Surg Oncol, 102, 264-70. https://doi.org/10.1002/jso.21623
  22. Yoshie O, Imai T, Nomiyama H (2001). Chemokines in immunity. Adv Immunol, 78, 57-110. https://doi.org/10.1016/S0065-2776(01)78002-9

Cited by

  1. E-Selectin S128R Polymorphism is Associated with Cancer Risk: a Meta-analysis vol.15, pp.7, 2014, https://doi.org/10.7314/APJCP.2014.15.7.3247
  2. Association of the -2518 A/G Polymorphism of MCP-1 with Breast Cancer in Punjab, North-West India vol.16, pp.16, 2015, https://doi.org/10.7314/APJCP.2015.16.16.7243
  3. Association of variants in genes encoding for macrophage-related functions with clinical outcome in patients with locoregional gastric cancer vol.26, pp.2, 2014, https://doi.org/10.1093/annonc/mdu542
  4. The rs1024611 in the CCL2 gene and risk of gynecological cancer in Asians: a meta-analysis vol.16, pp.1, 2018, https://doi.org/10.1186/s12957-018-1335-4
  5. Association between NR3C1 rs41423247 polymorphism and depression vol.97, pp.39, 2018, https://doi.org/10.1097/MD.0000000000012541