- Volume 14 Issue 6
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Non-Hodgkin Lymphoma and Pesticide Exposure in Turkey
- Yildirim, Mustafa (Department of Medical Oncology, Ministry of Health Batman Regional Govermant Hospital) ;
- Karakilinc, Hulya (Cancer Registration Center, Antalya Provincial Health Directorate) ;
- Yildiz, Mustafa (Department of Medical Oncology, Antalya Education and Research Hospital) ;
- Kurtoglu, Erdal (Department of Hematology, Antalya Education and Research Hospital) ;
- Dilli, Utku Donem (Department of Medical Oncology, Antalya Education and Research Hospital) ;
- Goktas, Sevil (Department of Medical Oncology, Antalya Education and Research Hospital) ;
- Demirpence, Ozlem (Department of Biochemistry, Ministry of Health Batman Regional Govermant Hospital) ;
- Kaya, Vildan (Department of Radiation Oncology, Suleyman Demirel University School of Medicine)
- Published : 2013.06.30
Background: Non-Hodgkin lymphoma (NHL) is a solid tumour of lymphocytes, important elements in the immune system. According to 2006 data, in Turkey the incidence was 6.5 per 100,000 in males, and 4.4 in females. The relationship between the use of pesticides and development of NHL has been extensively investigated in many studies, and it has been demonstrated that the risk of NHL is increased by exposure to such compounds. Antalya is a region of intensive agricultural activity. In this study, the relationship between the incidence of lymphoma in Antalya and the amount of pesticides employed was investigated. Materials and Methods: The study used data from 1995 to 2010 on the patients from the databank of TR Ministry of Health, Antalya Provincial Health Directorate, Cancer Registration Center and the patients who were histopathologically diagnosed with NHL during these years. Results: The relationship between the amount of pesticide used and the incidence was studied with the Spearman correlation analysis and the p value was found as 0.05. The correlation coefficient was 0.497. An increase in the NHL incidence over the years was identified, with a 2.42-fold increment found from 1995 to 2005 and a 2.77 fold elevation from 1995 to 2010. The use of pesticides increased 1.89 fold over the same period. Conclusions: Our study investigated the relationship of the pesticides used with NHL patients diagnosed during the same year. Since the time elapsing after exposure to pesticides until the development of cancer is not clear, no comparison can be made at present. We believe that the increase in use of pesticides since 1995 may be associated with the increase in the incidence of NHLand therefore that further studies on the issue including measurements of serum pesticide levels, are required.
- Barista I, Tekuzman G, Firat D, et al (1994). Non-Hodgkin's lymphomas in Turkey: eighteen years' experience at the Hacettepe University. Jpn J Cancer Res, 85, 1200-7. https://doi.org/10.1111/j.1349-7006.1994.tb02930.x
- Bertazzi PA, Consonni D, Bichetti S, et al (2001). Health effects of dioxin exposure: a 20 year mortality study. Am J Epidemiol, 153, 1031-44. https://doi.org/10.1093/aje/153.11.1031
- Alavanja MC, Ross MK, Bonner MR (2013). Increased cancer burden among pesticide applicators and others due to pesticide exposure. CA Cancer J Clin, 63, 120-42. https://doi.org/10.3322/caac.21170
- American Cancer Society (2005). Cancer Facts and Figures.
- Bertrand KA, Spiegelman D, Aster JC, et al (2010). Plasma organochlorine levels and risk of non-Hodgkin lymphoma in a cohort of men. Epidemiology, 21, 172-80. https://doi.org/10.1097/EDE.0b013e3181cb610b
- Berz D, Castillo JJ, Quilliam DN, et al (2011). Pesticides and non-Hodgkin lymphoma: an overview for the clinician. Med Health R I, 94, 10-2.
- Chiu BC, Blair A (2009). Pesticides, chromosomal aberrations, and non-Hodgkin's lymphoma. Review J Agromedicine, 14, 250-5. https://doi.org/10.1080/10599240902773140
- Clarke CA, Glaser SL, Dorfman RF, et al (2004). Expert review of non-Hodgkin's lymphomas in a population-based cancer registry: reliability of diagnosis and subtype classifications. Cancer Epidemiol Biomarkers Prev, 13, 138-43. https://doi.org/10.1158/1055-9965.EPI-03-0250
- Cocco P, Brennan P, Ibba A, et al (2008). Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes. Occup Environ Med, 65, 132-40. https://doi.org/10.1136/oem.2007.033548
- Cocco P, Satta G, Dubois S, et al (2013). Lymphoma risk and occupational exposure to pesticides: results of the Epilymph study. Occup Environ Med, 70, 91-8. https://doi.org/10.1136/oemed-2012-100845
- Eser S, Yakut C, Ozdemir R, et al (2010). Cancer incidence rates in Turkey in 2006: a detailed registry based estimation. Asian Pac J Cancer Prev, 11, 1731-9.
- Hardell L, Eriksson M, Lenner P, et al (1981). Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids. Br J Cancer, 43, 169-76. https://doi.org/10.1038/bjc.1981.25
- Howlader N, Noone AM, Krapcho M, et al (2012). SEER Cancer Statistics Review, posted to the SEER web site.
- Kogevinas M, Kauppinen T, Winkelmann R, et al (1995). Softtissue sarcoma and non-Hodgkin's lymphoma in workers exposed to phenoxy herbicides, chlorophenols and dioxins: two nested case-control studies. Epidemiol, 6, 396-402. https://doi.org/10.1097/00001648-199507000-00012
- Kogevinas M, Becher H, Benn T, et al (1997). Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols and dioxins: an expanded and updated international study. Am J Epidemiol, 145, 1061-75. https://doi.org/10.1093/oxfordjournals.aje.a009069
- Laden F, Bertrand KA, Altshul L, et al (2010). Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the nurses' health study. Cancer Epidemiol Biomarkers Prev, 19, 1381-4. https://doi.org/10.1158/1055-9965.EPI-10-0125
- Miligi L, Costantini AS, Bolejack V, et al (2003). Non-Hodgkin's lymphoma, leukemia, and exposures in agriculture. Am J Ind Med, 44, 627-36. https://doi.org/10.1002/ajim.10289
- Olsson H, Brandt L (1988). Risk of non-Hodgkin's lymphoma among men occupationally exposed to organic solvents. Scand J Work Environ Health, 14, 246-51. https://doi.org/10.5271/sjweh.1925
- Pahwa M, Harris SA, Hohenadel K, et al (2012). Pesticide use, immunologic conditions, and risk of non-Hodgkin lymphoma in Canadian men in six provinces. Int J Cancer, 131, 2650-9. https://doi.org/10.1002/ijc.27522
- Parent-Massin D, Thouvenot D (1993). In vitro study of pesticide hematotoxicity in human and rat progenitors. J Pharmacol Toxicol Methods, 30, 203-7. https://doi.org/10.1016/1056-8719(93)90018-A
- Paydas S, Ergin M, Tanriverdi K, et al (2004). Detection of hepatitis C virus RNA in paraffin-embedded tissues from patients with non-Hodgkin's lymphoma. Am J Hematol, 76, 252-7. https://doi.org/10.1002/ajh.20092
- Pearce NE, Smith AH, Howard JK, et al (1986). Non-Hodgkin's lymphoma and exposure to phenoxyherbicides, chlorophenols, fencing work, and meat worksemployment: a case-control study. Br J Ind Med, 43, 75-83.
- Pearce NE, Sheppard RA, Smith AH, et al (1987). Non-Hodgkin's lymphoma and farming. Int J Cancer, 39, 155-61. https://doi.org/10.1002/ijc.2910390206
- Richardson DB, Terschuren C, Hoffmann W (2008). Occupational risk factors for non-Hodgkin's lymphoma. Am J Ind Med, 51, 258-68. https://doi.org/10.1002/ajim.20552
- Shakeel MK, George PS, Jose J, et al (2010). Pesticides and breast cancer risk: a comparison between developed and developing countries. Asian Pac J Cancer Prev, 11, 173-80.
- Spinelli JJ, Ng CH, Weber JP, et al (2007). Organochlorines and risk of non-Hodgkin lymphoma. Int J Cancer, 121, 2767-75. https://doi.org/10.1002/ijc.23005
- Woods JS, Polissar L, Severson RK, et al (1987). Soft tissue sarcoma and non-Hodgkin's lymphoma inrelation to phenoxyherbicide and chlorinated phenol exposurein western Washington. J Natl Cancer Inst, 78, 899-910.
- Zahm, S, Ward MH, Blair A (1997). Pesticides and cancer. In: Keifer, MC., editor. Human Health Effects of Pesticides, 269-289.
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