DOI QR코드

DOI QR Code

Roles of Plant Extracts and Constituents in Cervical Cancer Therapy

  • Kma, Lakhan (Cancer and Radiation Countermeasures Unit, Department of Biochemistry North-Eastern Hill University)
  • Published : 2013.06.30

Abstract

Cervical cancer is a major health problem worldwide and is the most frequent cause of cancer in women in India. Early detection and affordable drugs with clinical efficacy have to go hand-in-hand in order to comprehensibly address this serious health challenge. Plant-based drugs with potent anticancer effects should add to the efforts to find a cheap drug with limited clinical side effects. Keeping this very purpose in mind, an attempt has been made in this review to explore the potential of plant extracts or constituents known to exhibit antitumorigenic activity or exert cytotoxic effect in human cervical carcinoma cells. Alkaloids such as those isolated from C. vincetoxicum and T. Tanakae, naucleaorals A and B, isolated from the roots of N. orientalis, (6aR)-normecambroline, isolated from the bark of N. dealbata appear promising in different human cervical carcinoma cells with the $IC_{50}$ of 4.0-8 ${\mu}g/mL$. However, other compounds such as rhinacanthone and neolignans isolated from different plants are not far behind and kill cervical cancer cells at a very low concentrations. Among plant extracts or its constituents that enhance the effect of known anticancer drugs, noni, derived from the plant M. citrifolia perhaps is the best candidate. The cytotoxic potency and apoptotic index of cisplatin was found to significantly enhanced in combination with noni in different human cervical carcinoma cells and it therefore holds significance as promising herbal-based anticancer agent. However, efficacy needs to be further investigated in various cervical cell lines and more importantly, in in vivo cervical cancer models for possible use as an alternative and safe anticancer drug.

Keywords

Cervical carcinoma cells;plant extracts / constituents;alkaloids;cytotoxicity

References

  1. Siripong P, Hahnvajanawong C, Yahuafai J, et al (2009). Induction of apoptosis by rhinacanthone isolated from Rhinacanthus nasutus roots in human cervical carcinoma cells. Biol Pharm Bull, 32, 1251-0. https://doi.org/10.1248/bpb.32.1251
  2. Staerk D, Lykkeberg AK, Christensen J, et al (2002). In vitro cytotoxic activity of phenanthroindolizidine alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against drug-sensitive and multidrug-resistant cancer cells. J Nat Prod, 65, 1299-2. https://doi.org/10.1021/np0106384
  3. Zou DM, Brewer M, Garcia F, et al (2005). Cactus pear: a natural product in cancer chemoprevention. Nutr J, 4, 25-6. https://doi.org/10.1186/1475-2891-4-25
  4. Staerk D, Christensen J, Lemmich E, et al (2000). Cytotoxic activity of some phenanthroindolizidine N-oxide alkaloids from Cynanchum vincetoxicum. J Nat Prod, 63, 1584-6. https://doi.org/10.1021/np0003443
  5. Taskin EI, Akgun-Dar K, Kapucu A, et al (2009). Apoptosisinducing effects of Morinda citrifolia L. and doxorubicin on the Ehrlich ascites tumor in Balb-c mice. Cell Biochem Funct, 27, 542-6. https://doi.org/10.1002/cbf.1604
  6. Teh SS, Cheng Lian Ee G, Mah SH, et al (2012). Mesua beccariana (Clusiaceae), a source of potential anti-cancer lead compounds in drug discovery. Molecules, 17, 10791-0. https://doi.org/10.3390/molecules170910791
  7. Tip-pyang S, Limpipatwattana Y, Khumkratok S, et al (2010). A new cytotoxic 1-azaanthraquinone from the stems of Goniothalamus laoticus. Fitoterapia, 81, 894-6. https://doi.org/10.1016/j.fitote.2010.05.019
  8. Tran TD, Pham NB, Fechner G, et al (2010). Chemical investigation of drug-like compounds from the Australian tree, Neolitseadealbata. Bioorg Med Chem Lett, 20, 5859-3. https://doi.org/10.1016/j.bmcl.2010.07.100
  9. Wan Q, Liu Z, Peng W, et al (2011). BnRCH gene inhibits cell growth of Hela cells through increasing the G2 phase of cell cycle. Hum Cell, 24, 150-0. https://doi.org/10.1007/s13577-011-0036-x
  10. Wang G, Huang W, He H, et al (2013). Growth inhibition and apoptosis-inducing effect on human cancer cells by RCE-4, a spirostanol saponin derivative from natural medicines. Int J Mol Med, 31, 219-4.
  11. Wang MK, Ding LS, Wu FE (2008). Antitumor effects of raddeanin A on S180, H22 and U14 cell xenografts in mice. Ai Zheng, 27, 910-3.
  12. Wang X, Beckham TH, Morris JC, et al (2008). Bioactivities of gossypol, 6-methoxygossypol, and 6,6'-dimethoxygossypol. J Agric Food Chem, 56, 4393-8. https://doi.org/10.1021/jf073297u
  13. Wongsirisin P, Yodkeeree S, Pompimon W, et al (2012). Induction of G1 arrest and apoptosis in human cancer cells by crebanine, an alkaloid from Stephania venosa. Chem Pharm Bull, 60, 1283-9. https://doi.org/10.1248/cpb.c12-00506
  14. Yakushiji M, Sugiyama T, Ushijima K (1997). Promising new drugs for gynecological cancer. Gan To Kagaku Ryoho, 24, 1932-7.
  15. Yu MI, Zhang CI, Yuan DD, et al (2012). Panax notoginseng saponins enhances the cytotoxicity of cisplatin via increasing gap junction intercellular communication. Biol Pharm Bull, 35, 1230-7. https://doi.org/10.1248/bpb.b110535
  16. Zheng PW, Chiang LC, Lin CC (2005). Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells. Life Sci, 76, 1367-79. https://doi.org/10.1016/j.lfs.2004.08.023
  17. Siripong P, Yahuafai J, Shimizu K, et al (2006a). Induction of apoptosis in tumor cells by three naphthoquinone esters isolated from Thai medicinal plant: Rhinacanthus nasutus KURZ. Biol Pharm Bull, 29, 2070-6. https://doi.org/10.1248/bpb.29.2070
  18. Siripong P, Yahuafai J, Shimizu K, et al (2006b). Antitumor activity of liposomal naphthoquinone esters isolated from Thai medicinal plant: Rhinacanthus nasutus KURZ. Biol Pharm Bull, 29, 2279-3. https://doi.org/10.1248/bpb.29.2279
  19. Akiyama T, Ueoka R, van Soest RW, et al (2009). Ceratodictyols, 1-glyceryl ethers from the red alga-sponge association Ceratodictyon spongiosum/Haliclona cymaeformis. J Nat Prod, 72, 1552-4. https://doi.org/10.1021/np900355m
  20. Alabsi AM, Ali R, Ali AM, et al (2012). Apoptosis induction, cell cycle arrest and in vitro anticancer activity of gonothalamin in a cancer cell lines. Asian Pac Cancer Prev, 13, 5131-6. https://doi.org/10.7314/APJCP.2012.13.10.5131
  21. Berrington D, Lall N (2012). Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line. Evid Based Complement Alternat Med, 564927-7.
  22. Booth GM, Malmstrom RD, Kipp E, et al (2012). Cytotoxicity of selected medicinal and nonmedicinal plant extracts to microbial and cervical cancer cells. J Biomed Biotechnol, 106746-0.
  23. Capua CJ, Hopson NP, Stewart CM, et al (2010). Cytotoxicity of Atriplex confertifolia. J Toxicol, 976548, 7.
  24. Castonguay A, Gali HU, Perchellet EM, et al (1997). Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin. Int J Oncol, 10, 367-3.
  25. Chae HJ, Park JM, Lee GY, et al (2004). Yuk-Hap-Tang induces apoptosis by intervening mn-SOD in human cervical carcinoma HeLa cells. Am J Chin Med, 32, 883-95. https://doi.org/10.1142/S0192415X04002491
  26. Chakrabarty S, Roy M, Hazra B, et al (2002). Induction of apoptosis in human cancer cell lines by diospyrin, a plantderived bisnaphthoquinonoid, and its synthetic derivatives. Cancer Lett, 188, 85-3. https://doi.org/10.1016/S0304-3835(02)00494-9
  27. Girdhani S, Bhosle SM, Thulsidas SA, et al (2005). Potential of radiosensitizing agents in cancer chemo-radiotherapy. J Cancer Res Ther, 1, 129-1. https://doi.org/10.4103/0973-1482.19585
  28. Gupta RK, Banerjee A, Pathak S, et al (2013). Induction of mitochondrial-mediated apoptosis by Morinda citrifolia (noni) in human cervical cancer cells. Asian Pac J Cancer Prev, 14, 237-2. https://doi.org/10.7314/APJCP.2013.14.1.237
  29. Hiramatsu T, Imoto M, Koyano T, et al (1993). Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia. Cancer Lett, 73, 161-6. https://doi.org/10.1016/0304-3835(93)90259-C
  30. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  31. Jung S, Moon HI, Ohk J, et al (2012). Inhibitory effect and mechanism on antiproliferation of isoatriplicolide tiglate (PCAC) from Paulownia coreana. Molecules, 17, 5945-1. https://doi.org/10.3390/molecules17055945
  32. Kaewpiboon C, Lirdprapamongkol K, Srisomsap C, et al (2012). Studies of the in vitro cytotoxic, antioxidant, lipase inhibitory and antimicrobial activities of selected Thai medicinal plants. BMC Comp Altern Med, 12, 217-4. https://doi.org/10.1186/1472-6882-12-217
  33. Kalaivani T, Rajasekaran C, Mathew L (2011). Free radical scavenging, cytotoxic, and hemolytic activities of an active antioxidant compound ethyl gallate from leaves of Acacia nilotica (L.) Wild. Ex. Delile subsp. indica (Benth.) Brenan. J Food Sci, 76, 144-9. https://doi.org/10.1111/j.1750-3841.2011.02243.x
  34. Larrosa M, Tomas-Barberan F, Espin J (2006). The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. J Nutr Biochem, 17, 611-25. https://doi.org/10.1016/j.jnutbio.2005.09.004
  35. Lee YJ, Kim J, Yi JM, et al (2012). Anti-proliferative neolignans from Saururus chinensis against human cancer cell lines. Biol Pharm Bull, 35, 1361-6. https://doi.org/10.1248/bpb.b110670
  36. Liebmann JE, Cook JA, Lipschultz C, et al (1993). Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines. Br J Cancer, 68, 1104-9. https://doi.org/10.1038/bjc.1993.488
  37. Liu G, Bode A, Ma WY, et al (2001) Two novel glycosides from the fruits of Morinda citrifolia (Noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line. Cancer Res, 61, 5749-56.
  38. Losso J, Bansode R, Trappey A, et al (2004). In vitro antiproliferative activities of ellagic acid. J Nutr Biochem, 15, 672-8. https://doi.org/10.1016/j.jnutbio.2004.06.004
  39. McDougall GJ, Ross HA, Ikeji M, et al (2008). Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro. J Agric Food Chem, 56, 3016-3. https://doi.org/10.1021/jf073469n
  40. Misikangas M, Paraji AM, Paivarinta E, et al (2007). Three nordic berries inhibit intestinal tumourigenesis in multiple intestinal neoplasia/+ mice by modulating beta-catenin signalling in the mucosa. J Nut, 137, 2285-0.
  41. Oskoueian E, Abdullah N, Ahmad S (2012). Phorbol esters from Jatropha meal triggered apoptosis, activated PKC-$\delta$, caspase-3 proteins and down-regulated the proto-oncogenes in MCF-7 and HeLa cancer cell lines. Molecules, 17, 10816-30. https://doi.org/10.3390/molecules170910816
  42. Pathak S, Bhatla N, Singh N (2012). Cervical cancer pathogenesis is associated with one carbon metabolism. Mol Cell Biochem, 369, 1-7. https://doi.org/10.1007/s11010-012-1362-3
  43. Petrin D, Delgaty K, Bhatt R, et al (1998). Clinical and microbiological aspects of Trichomonas vaginalis. Clin Microbiol Rev, 11, 300-17.
  44. Post-White J, Ladas EJ, Kelly KM (2007). Advances in the use of milk thistle (Silybum marianum). Integr Cancer Ther, 6, 104-9. https://doi.org/10.1177/1534735407301632
  45. Rocha TD, de Brum Vieira P, Gnoatto SC, et al (2012). Anti-Trichomonas vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species. Parasitol Res, 110, 2551-6. https://doi.org/10.1007/s00436-011-2798-1
  46. Ross HA, McDougall GJ, Stewart D (2007). Antiproliferative activity is predominantly associated with ellagitannins in raspberry extracts. Phytochemistry, 68, 218-8. https://doi.org/10.1016/j.phytochem.2006.10.014
  47. Seeram NP, Aronson WJ, Zhang Y, et al (2007). Pomegranate ellagitannin-derived metabolites inhibit prostrate cancer growth and localize to the mouse prostrate gland. J Agric Food Chem, 55, 7732-7. https://doi.org/10.1021/jf071303g
  48. Sichaem J, Surapinit S, Siripong P, et al (2010). Two new cytotoxic isomeric indole alkaloids from the roots of Nauclea orientalis. Fitoterapia, 81, 830-3. https://doi.org/10.1016/j.fitote.2010.05.004

Cited by

  1. Saponins from Rubus parvifolius L. Induce Apoptosis in Human Chronic Myeloid Leukemia Cells through AMPK Activation and STAT3 Inhibition vol.15, pp.13, 2014, https://doi.org/10.7314/APJCP.2014.15.13.5455
  2. Cytotoxicity Assessments of Portulaca oleracea and Petroselinum sativum Seed Extracts on Human Hepatocellular Carcinoma Cells (HepG2) vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6633
  3. Cytotoxicity of Nigella Sativa Seed Oil and Extract Against Human Lung Cancer Cell Line vol.15, pp.2, 2014, https://doi.org/10.7314/APJCP.2014.15.2.983
  4. Autophagy-associated Targeting Pathways of Natural Products during Cancer Treatment vol.15, pp.24, 2015, https://doi.org/10.7314/APJCP.2014.15.24.10557
  5. Antioxidant, Anticancer and Anticholinesterase Activities of Flower, Fruit and Seed Extracts of Hypericum amblysepalum HOCHST vol.16, pp.7, 2015, https://doi.org/10.7314/APJCP.2015.16.7.2763
  6. Portulaca oleracea Seed Oil Exerts Cytotoxic Effects on Human Liver Cancer (HepG2) and Human Lung Cancer (A-549) Cell Lines vol.16, pp.8, 2015, https://doi.org/10.7314/APJCP.2015.16.8.3383
  7. Praeruptorin A Inhibits Human Cervical Cancer Cell Growth and Invasion by Suppressing MMP-2 Expression and ERK1/2 Signaling vol.19, pp.1, 2017, https://doi.org/10.3390/ijms19010010