Mycoplasma genitalium and Cancer: A Brief Review

  • Zarei, Omid (Biotechnology Research Center, Biomedicine Research Institute) ;
  • Rezania, Simin (Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences) ;
  • Mousavi, Atefeh (Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences)
  • Published : 2013.06.30


Approximately, 15-20% of all cancers worldwide are caused by infectious agents. Understanding the role of infectious agents on cancer development might be useful for developing new approaches to its prevention. Mycoplasma genitalium is a clinically important sexually transmitted pathogen that has been associated with several human diseases. There have been a few studies suggestive of probable roles of Mycoplasma genitalium in cancer development, including prostate and ovarian cancers and lymphomas, but the role of this microorganism like other Mycoplasma species in neoplasia is still conjectural. Considering the prevalence of Mycoplasma genitalium infections and also the emergence of resistant strains, Mycoplasma genitalium needs more attention in the infectious agent cancer-causing research area.


  1. Adegboye DS, Halbur PG, Cavanaugh DL, et al (1995). Immunohistochemical and pathological study of Mycoplasma bovis-associated lung abscesses in calves. J Vet Diagn Invest, 7, 333-7.
  2. Baracaldo R, Foltzer M, Patel R, Bourbeau P (2012). Empyema caused by Mycoplasma salivarium. J Clin Microbiol, 50, 1805-6.
  3. Barile MF (1967). Mycoplasma and leukemia. Ann NY Acad Sci, 143, 557-72.
  4. Barykova YA, Logunov DY, Shmarov MM, et al (2011). Association of Mycoplasma hominis infection with prostate cancer. Oncotarget, 2, 289.
  5. Baseman J, Dallo S, Tully J, Rose D (1988). Isolation and characterization of Mycoplasma genitalium strains from the human respiratory tract. J Clin Microbiol, 26, 2266-9.
  6. Baseman JB, Cagle M, Korte JE, et al (2004). Diagnostic assessment of Mycoplasma genitalium in culture-positive women. J Clin Microbiol, 42, 203-11.
  7. Bergonzini V, Salata C, Calistri A, et al (2010). View and review on viral oncology research. Infect Agent Cancer, 5, 11.
  8. Biernat-Sudolska M, Szostek S, Rojek-Zakrzewska D, et al (2011). Concomitant infections with human papillomavirus and various mycoplasma and ureaplasma species in women with abnormal cervical cytology. Adv Med Sci, 56, 299-303.
  9. Bradshaw CS, Chen MY, Fairley CK (2008). Persistence of Mycoplasma genitalium following azithromycin therapy. PLoS One, 3, 3618.
  10. Burgos R, Pich OQ, Ferrer-Navarro M, et al (2006). Mycoplasma genitalium P140 and P110 cytadhesins are reciprocally stabilized and required for cell adhesion and terminalorganelle development. J Bacteriol, 188, 8627-37.
  11. Chanudet E, Adam P, Nicholson A, et al (2007). Chlamydiae and Mycoplasma infections in pulmonary MALT lymphoma. Br J Cancer, 97, 949-51.
  12. Clausen HF, Fedder J, Drasbek M, et al (2001). Serological investigation of Mycoplasma genitalium in infertile women. Hum Reprod, 16, 1866-74.
  13. Cohen C, Mugo N, Astete S, et al (2005). Detection of Mycoplasma genitalium in women with laparoscopically diagnosed acute salpingitis. Sex Transm Infect, 81, 463-6.
  14. Cohen CR, Manhart LE, Bukusi EA, et al (2002). Association between Mycoplasma genitalium and acute endometritis. The Lancet, 359, 765-6.
  15. de Barbeyrac B, Bernet-Poggi C, Febrer F, et al (1993). Detection of Mycoplasma pneumoniae and Mycoplasma genitalium in clinical samples by polymerase chain reaction. Clin Infect Dis, 17, 83-9.
  16. de Martel C, Franceschi S (2009). Infections and cancer: established associations and new hypotheses. Crit Rev Oncol Hematol, 70, 183-94.
  17. Ebbesen P, Lind K (1969). Lack of evidence for oncogenic or amyloid inducing qualities of Mycoplasma neurolyticum inoculated into BALB/c mice. Acta Path Micro Im B, 76, 594-600.
  18. Edberg A, Jurstrand M, Johansson E, et al (2008). A comparative study of three different PCR assays for detection of Mycoplasma genitalium in urogenital specimens from men and women. J Med Microbiol, 57, 304-9.
  19. Erturhan SM, Bayrak O, Pehlivan S, et al (2013). Can mycoplasma contribute to formation of prostate cancer? Int Urol Nephrol, 45, 33-8.
  20. Falk L, Fredlund H, Jensen J (2005). Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection. Sex Transm Infect, 81, 73-8.
  21. Fallon R, Grist N, Inman D, et al (1965). Further studies of agents isolated from tissue cultures inoculated with human leukaemic bone-marrow. Br Med J, 2, 388-91.
  22. Feng SH, Tsai S, Rodriguez J, Lo SC (1999). Mycoplasmal infections prevent apoptosis and induce malignant transformation of interleukin-3-dependent 32D hematopoietic cells. Mol Cell Biol, 19, 7995-8002.
  23. Grace Jr JT, Horoszewicz JS, Stim TB, et al (1965). Mycoplasmas (PPLO) and human leukemia and lymphoma. Cancer, 18, 1369-76.<1369::AID-CNCR2820181022>3.0.CO;2-2
  24. Hayflick L, Koprowski H (1965). Direct agar isolation of Mycoplasmas from human leukaemic bone marrow. Nature, 205, 713-4.
  25. Heiskanen-Kosma T, Korppi M, Kleemola M, Heinonen K (1992). RNA hybridization for Mycoplasma pneumoniae: a new tool for following the epidemiological situation. Acta Paediatr, 81,705-6.
  26. Huang S, Li JY, Wu J, et al (2001). Mycoplasma infections and different human carcinomas. World J Gastroenterol, 7, 266-9.
  27. Idahl A, Lundin E, Elgh F, et al (2010). Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus, and polyomavirus are not detectable in human tissue with epithelial ovarian cancer, borderline tumor, or benign conditions. Am J Obstet Gynecol, 202, 71.
  28. Idahl A, Lundin E, Jurstrand M, et al (2011). Chlamydia trachomatis and Mycoplasma genitalium plasma antibodies in relation to epithelial ovarian tumors. Infect Dis Obstet Gynecol, 2011, 824627.
  29. Jensen J, Orsum R, Dohn B, et al (1993). Mycoplasma genitalium: a cause of male urethritis? Genitourin Med, 69, 265-9.
  30. Jensen JS, Bradshaw CS, Tabrizi SN, et al (2008). Azithromycin treatment failure in Mycoplasma genitalium–positive patients with nongonococcal urethritis is associated with induced macrolide resistance. Clin Infect Dis, 47, 1546-53.
  31. Ji J, Zhang J, Shou C, et al (2002). Mycoplasma hyorhinis in gastric cancer. Chin J Cancer Res, 14, 84-7.
  32. Jones L, Felblinger D, Cooper L (2009). Mycoplasma genitalium: more prevalent than you think. Nurse Pract, 34, 50.
  33. Jun C, Jianping L, Wei C, Qi C (2008). Clinical significance of detection of Mycoplasma DNA in renal cell carcinoma. Acad J Xian Jiaotong Univ, 6, 023.
  34. Jurstrand M, Jensen JS, Fredlund H, et al (2005). Detection of Mycoplasma genitalium in urogenital specimens by realtime PCR and by conventional PCR assay. J Med Microbiol, 54, 23-9.
  35. Khurana S, Dubey M, Malla N (2005). Association of parasitic infections and cancers. Indian J Med Microbiol, 23, 74.
  36. Krieger JN, Riley DE (2004). Chronic prostatitis: Charlottesville to Seattle. J Urol, 172, 2557-60.
  37. Kwon D, Chae C (1999). Detection and localization of Mycoplasma hyopneumoniae DNA in lungs from naturally infected pigs by in situ hybridization using a digoxigeninlabeled probe. Vet Pathol, 36, 308-13.
  38. MacPherson I, Russell W (1966). Transformations in hamster cells mediated by Mycoplasmas. Nature, 210, 1343-5.
  39. Mandar R, Raukas E, Turk S, et al (2005). Mycoplasmas in semen of chronic prostatitis patients. Scand J Urol Nephrol, 39, 479-82.
  40. McCully M, Brock K (1992). Development of a DNA hybridization probe for detection of Mycoplasma bovis. J Vet Diagn Invest, 4, 464-7.
  41. Moorkamp L, Grosse BE, Hewicker-Trautwein M (2010). Immunohistochemistry and polymerase chain reaction for detection of Mycoplasma hyopneumoniae infection in piglets. Vaccine, 27, 12.
  42. Murphy WH, Bullis C, Dabich L, et al (1970). Isolation of Mycoplasma from leukemic and nonleukemic patients. J Natl Cancer Inst, 45, 243-51.
  43. Murphy WH, Bullis C, Ertel IJ, Zarafonetis CJ (1967). Mycoplasma studies of human leukemia. Ann NY Acad Sci, 143, 544-56.
  44. Murphy WH, Ertel IJ, Bullis C, Zarafonetis CJ (1967). Antibodies to Mycoplasma in sera of leukemic patients. Proc Soc Exp Biol Med, 124, 366-72.
  45. Murphy WH, Furtado D, Plata E (1965). Possible association between leukemia in children and virus-like agents. JAMA, 191, 110-5.
  46. Namiki K, Goodison S, Porvasnik S, et al (2009). Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells. PLoS One, 4, 6872.
  47. Ouzounova-Raykova VV, Markovska R, Mizgova G, Mitov IG (2011). Detection of the sexually transmissible genital Mycoplasmas by polymerase chain reaction in women. Sexual Hlth, 8, 445-6.
  48. Parkin DM (2006). The global health burden of infectionassociated cancers in the year 2002. Int J Cancer, 118, 3030-44.
  49. Paton G, Jacobs J, Perkins F (1965). Chromosome changes in human diploid-cell cultures infected with Mycoplasma. Nature, 207, 43.
  50. Pehlivan M, Pehlivan S, Onay H, et al (2005). Can Mycoplasmamediated oncogenesis be responsible for formation of conventional renal cell carcinoma? Urology, 65, 411-4.
  51. Razin S, Yogev D, Naot Y (1998). Molecular biology and pathogenicity of Mycoplasmas. Microbiol Mol Biol Rev, 62, 1094-156.
  52. Saglie R, Cheng L, Sadighi R (1988). Detection of Mycoplasma pneumoniae-DNA within diseased gingiva by in situ hybridization using a biotin-labeled probe. J Periodontol, 59, 121-3.
  53. Shaw-Huey F, Shien T, Rodriguez J, Shyh-Ching L (1999). Mycoplasma infections prevent apoptosis and induce malignant transformation of interleukin-3-dependent 32D hematopoietic cells. Mol Cel Biol, 19, 7995-8002.
  54. Simms I, Eastick K, Mallinson H, et al (2003). Associations between Mycoplasma genitalium, Chlamydia trachomatis and pelvic inflammatory disease. J Clin Pathol, 56, 616-8.
  55. Soni S, Alexander S, Verlander N, et al (2010). The prevalence of urethral and rectal Mycoplasma genitalium and its associations in men who have sex with men attending a genitourinary medicine clinic. Sex Transm Infect, 86, 21-4.
  56. Svenstrup HF, Jensen JS, Gevaert K, et al (2006). Identification and characterization of immunogenic proteins of Mycoplasma genitalium. Clin Vaccine Immunol, 13, 913-22.
  57. Svenstrup HF, NIELSEN PK, DRASBEK M, et al (2002). Adhesion and inhibition assay of Mycoplasma genitalium and M. pneumoniae by immunofluorescence microscopy. J Med Microbiol, 51, 361-73.
  58. Totten PA, Schwartz MA, Sjostrom KE, et al (2001). Association of Mycoplasma genitalium with nongonococcal urethritis in heterosexual men. J Infect Dis, 183,269-76.
  59. Tsai S, Wear DJ, Shih J, Lo SC (1995). Mycoplasmas and oncogenesis: persistent infection and multistage malignant transformation. PNAS, 92, 10197-201.
  60. Tully JG, Cole RM, Taylor-Robinson D, Rose DL (1981). A newly discovered Mycoplasma in the human urogenital tract. The Lancet, 317, 1288-91.
  61. Tully JG, Rose DL, Baseman JB, et al (1995). Mycoplasma pneumoniae and Mycoplasma genitalium mixture in synovial fluid isolate. J Clin Microbiol, 33, 1851-5.
  62. Tully JG, Taylor-Robinson D, Rose Dl, et al (1983). Mycoplasma genitalium, a new species from the human urogenital tract. Int J Syst Bacteriol, 33, 387-96.
  63. Twin J, Taylor N, Garland SM, et al (2011). Comparison of two Mycoplasma genitalium real-time PCR detection methodologies. J Clin Microbiol, 49, 1140-2.
  64. Vogelmann R, Amieva MR (2007). The role of bacterial pathogens in cancer. Curr Opin Microbiol, 10, 76-81.
  65. Yang H, Qu L, Ma H, et al (2010). Mycoplasma hyorhinis infection in gastric carcinoma and its effects on the malignant phenotypes of gastric cancer cells. BMC Gastroenterol, 10, 132.
  66. Yang H, Zhang J, Shou C (2010). Detection of Mycoplasma hyorhinis infection in ovarian cancer with in situ hybridization and immunohistochemistry. Clin Oncol Cancer Res, 7, 294-8.
  67. YanYing Z, ZhiXian Y, LiPing Z (2009). Detection of Mycoplasma penetrans in transitional cell carcinoma of bladder. Chin J Zoonoses, 25, 238-40.
  68. Zarei O, Irajian GR, Zarnani AH, et al (2011). Peptide-based polyclonal antibody production against P110 protein of Mycoplasma genitalium. Avicenna J Med Biotech, 3,79-86.
  69. Zhang B, Tsai S, Shih JWK, et al (1998). Absence of Mycoplasmal gene in malignant mammalian cells transformed by chronic persistent infection of Mycoplasmas. Proc Soc Exp Biol Med, 218, 83-9.
  70. Zhang S, Lo SC (2007). Effect of Mycoplasmas on apoptosis of 32D cells is species-dependent. Curr Microbiol, 54, 388-95.
  71. Zhang S, Tsai S, Geissel A, et al (1999). Mycoplasmamediated malignant transformation of IL-3 dependent 32D hematopoietic cells is associated with constitutive expression of a high level of c-Myc gene. In 99th General Meeting of the American Society for Microbiology. Atlantic City, 32.
  72. Zhang S, Tsai S, Lo SC (2006). Alteration of gene expression profiles during Mycoplasma-induced malignant cell transformation. BMC Cancer, 6, 116.
  73. Zhang S, Tsai S, Wu TT, et al (2004). Mycoplasma fermentans infection promotes immortalization of human peripheral blood mononuclear cells in culture. Blood, 104, 4252-9.
  74. Zhang S, Wear DJ, Lo SC (2006). Mycoplasmal infections alter gene expression in cultured human prostatic and cervical epithelial cells. FEMS Immunol Med Microbiol, 27, 43-50.
  75. Zhu Y-y, Zhou L-p, Zhang Q, et al (2007). Isolation of Mycoplasma penetrans from blood and tissue specimens of patients with cervical cancer. Chin J Zoonoses, 23, 537.

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