- Volume 23 Issue 7
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Antibacterial Effect of Amentoflavone and Its Synergistic Effect with Antibiotics
- Hwang, Ji Hong (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University) ;
- Choi, Hyemin (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University) ;
- Woo, Eun-Rhan (College of Pharmacy, Chosun University) ;
- Lee, Dong Gun (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
- Received : 2013.02.21
- Accepted : 2013.04.08
- Published : 2013.07.28
Selaginella tamariscina is a traditional herb used in medicine. Phytochemical amentoflavone, a biflavonoid class of flavonoids, was isolated from the plant of Selaginella tamariscina. In this study, the antibacterial effects and combination effects of amentoflavone and conventional antibiotics such as ampicillin, cefotaxime, and chloramphenicol were investigated. These results showed that amentoflavone had a considerable antibacterial effect and synergistic interaction with antibiotics against various bacterial strains (fractional inhibitory concentration index
Supported by : National Research Foundation of Korea (NRF)
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