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Synthesis of 2-Substituted Benzofurans from o-Iodophenols and Terminal Alkynes with a Recyclable Palladium Catalyst Supported on Nano-sized Carbon Balls under Copper- and Ligand-Free Conditions

  • Yum, Eul Kgun (Department of Chemistry, Chungnam National University) ;
  • Yang, Ok-Kyung (Department of Chemistry, Chungnam National University) ;
  • Kim, Ji-Eun (Department of Chemistry, Chungnam National University) ;
  • Park, Hee Jung (Korea Basic Science Institute)
  • Received : 2013.04.11
  • Accepted : 2013.06.10
  • Published : 2013.09.20

Abstract

We have developed a one-step synthesis of benzofurans from o-iodophenol and various terminal alkynes, by using Pd catalyst supported on nano-sized carbon balls (NCB) under copper- and ligand free conditions. This recyclable catalyst could be reused more than 5 times in the same heteroannulation reaction. The results have demonstrated that diverse 2-substituted benzofurans with tolerant functional groups can be prepared simply and conveniently under these conditions.

Acknowledgement

Grant : Human Resource Development Center for Economic Region Leading Industry

Supported by : National Research Foundation of Korea (NRF)

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