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Effects of Jebikong (Dolichos lablab) Extract on Serum Lipid Metabolism in Rats Fed a High Fat Diet

제비콩 추출물이 고지방 식이 급여에 의한 흰쥐의 혈청 지질 함량에 미치는 영향

  • Received : 2013.04.08
  • Accepted : 2013.06.25
  • Published : 2013.08.30

Abstract

This study investigated the effect of Dolichos lablab extract on the lipid metabolism of rats fed a high fat and cholesterol diet. S-D male rats (n=48) were given 40, 400, or 4000 mg/kg of Dolichos lablab extract and fed a high fat and high cholesterol diet for four weeks (DL-HFC group). As a result, serum levels of total lipids, total cholesterol, and triglycerides were higher in the high fat and high cholesterol group (HFC-group) than the control, and significant differences were observed between the control and the DL-HFC (40, 400, 4000 mg/kg) group. The fat absorption rate increased with a high fat diet feeding, but was higher in the DL-HFC (40, 400, 4000 mg/kg) group.

Keywords

Jebikong (Dolichos lablab) extract;triglyceride;total cholesterol;HDL-cholesteol;LDL-cholesterol

References

  1. Akitha MK, Gondi M, Saktchivelu G, Giridhar P, Rajasekaran T, Ravishankar GA. 2009. Fntional attributes of soybean seeds and products, with reference to isoflavone content and antioxidant activity. Food Chem 114, 771-776 https://doi.org/10.1016/j.foodchem.2008.10.011
  2. Anderson JW, Johnstone BM, Cook-Newell ME. 1995. Metaanalysis of the effects of soy protein intake on serum lipids. N Engl J Med, 333(9):279-282
  3. Bae EA, Moon GS. 1997. A study on the antioxidative activities of lorean soybeans. J Korean Soc Food Sci Nutr, 26(2):203-208
  4. Barnes S, Grubbs C, Setchell KDR, Carlson J. 1990. Soybean inhibit mammary tumors in models of breat cancer. In: Pariza M, Liss A, editors. Mutagens and carcinogens in the diet. New York. Wiley Liss, pp. 239-253
  5. Choi JW, Lee CK, Lee YC, Moon YI, Park HJ, Han YN. 2002. Biological activities of the extracts from fruit and stem of prickly pear (Opuntia ficus-indica var. Kor J Pharm Cogn. 33(3):230-237
  6. Chen JR, Chiou SF, Suetsuna K, Yang HY, Yang SC. 2003. Lipid metabolism in hypercholesterolemic rats affectred by feeding cholesterol-free diets containing different amounts of non dialyzed soybean protein fraction. Nutrition, 19(7):676-680 https://doi.org/10.1016/S0899-9007(03)00072-8
  7. Fernandez Ml, Mcnamara DJ. 1991. Regulation of cholesterol and lipid protein metabolism in guinea pigs mediated by dietary fat quality and quantity. J Nutr, 121(5):934-943 https://doi.org/10.1093/jn/121.7.934
  8. Gotto AM Jr, Farmer JA. 2006. Drug insight the role of statins in combination with ezetimibe to lower LDL-cholesterol. Nature Reviews cardiology, 3(12):664-672
  9. Han YH, Park SK, Kim HY. 2008. Effect of soy protein in hydrolyzate on lipid metabolism and antioxidant activity in the rat. Korean J Nutr, 41(2):119-126
  10. Joo KH, Shin YK, Lee MS. 1996. Effect of salt and alcohol on orginic acids content during aging of chongkukjang. J Food Sci Technol, 28(1):13-23
  11. Korea ministry of health and welfare. 2003. In: Depth Analysis on 2001. National health and nutrition survey-nutrition survey. KHIDI, Seoul. Korea, 188-200
  12. Kim YW, Choi WC, Shin MK, Han SH, Lim SJ, Kim MA. 2001. Effects of Jebikong leaves extract on enzyme activities in mice blood. Korean Journal of organic agriculture, 9(3):85-92
  13. Kim BN, Kim D. Ham SS. Lee SY. 1995. Effects of spice added natto supplementation on the lipid merabolism in rats. J Korean Soc Food Sci Nutr, 24(1):121-126
  14. Kulling SE, Hong DM, Metzler M. 2001. Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo. J Agric Food Chem, 49(11):3024-3033 https://doi.org/10.1021/jf0012695
  15. Kwon TW, Song YS. 1996. Health functions of soybean foods. proceeding of IUFOST 96 regional symposium on nonnutritional health factors for future foods, Sep 13; Seoul
  16. Kwoon TW, Song YS, Hong JH, Moon GS, Kim JI, Hong JH. 1998. Current research on the bioactive functions of soyfoods in korea. Korea Soybean Digest, 15(1):1-2
  17. Lee KS, Kim JB. 2009. Effects of the sarcodon aspralus on the high level of blood lipid and obesity induced by high fatdiet in rat. J Life Science, 19(9):1265-1270 https://doi.org/10.5352/JLS.2009.19.9.1265
  18. Lim SJ Kim YW, Kim MA, Choi WC, Yoon HT. 2001. Determination and isolation of leaf isoflavone in Hyacinth bean. Korean J Crop Sci, 46(6):449-452
  19. Liao HF, Chen Y, Yang YC. 2005. A novel polysaccharide of black soybean promotes myelopoiesis and irradiation induced myelosuppression. Life science, 77(4):400-412 https://doi.org/10.1016/j.lfs.2004.10.080
  20. Liyange R, Han KH, Watanabe S, Shibyma S, Nakamori T, Fukushima M. 2008. Potato and soy peptide diets modulate lipid metabolism in rats. Biosci. Biotech, 72(4):943-950 https://doi.org/10.1271/bbb.70593
  21. Messina M, Persky V, Setehell KDR, Barnes S. 1994. Soy intake and cancer risk, a review of in vitro and in vivo data. Nutr cancer. 21(2):113-131 https://doi.org/10.1080/01635589409514310
  22. Messina M. 1995. Modern application for an ancient bean, soybeans and the prevention and treatment of chronic disease. J Nutr, 125(3):567-574
  23. Mitchell JH, Gardner PT, McPhail DB, Morrice PC, Collins AR, Duthie GG. 1998.
  24. Antioxidant efficacy of phytoestrogens in chemical and bioligical model systems. Arch Biochem Biophys, 360(1):142-148
  25. Muruganandan S, Crinivasan K, Gupta S, Gupta PK, Lai J. 2005. Effect of mangiferrin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. J Ethnoparmacol, 97(3):495-501
  26. Myung JE, Hwang IK. 2008. Functional components and antioxidative activities of soybean extracts. Korean soybean digest, 25(1):23-29
  27. National Statistic office. 2003. Annual report on the cause of death statistics. National statistic office, seoul, Korea, 150-160
  28. Oakenfull D, Sidhy. GS. 1990. Coul saponins be as uesful treatment for hypercholesterolaemia? Eur J Clin Nutr, 44(1):79-88
  29. Park SH, Ko SK. Chung SH. 2005. Euonymus alatus prevents the hyperglycemis and hyperlipidemia induced by high-fat in ICR mice. J Ethnopharmacol, 102(3):326-335 https://doi.org/10.1016/j.jep.2005.06.041
  30. Potter SM, Bakhit RM, Essex-Sorlie D. 1998. Depression of plasma cholesterol in men by consumption of baked products containing soy protein. Am J Clin Nutr, 58(3):501-506
  31. Shin MK. Han SH. 1999. Effects of soybean extract on serum lipid contents in fed fat diet rats. Korean J Food Sci Technol, 31(3):809-814
  32. Toda S, Shirataki Y. 1999. Inhibitory effects of isoflavones on lipid peroxidation by reactive oxygen species. Phytotherapy Res, 13(2):163-165 https://doi.org/10.1002/(SICI)1099-1573(199903)13:2<163::AID-PTR405>3.0.CO;2-#
  33. Wat E, Tandy S, Kapera E, Kamili A, Chung RWS, Brown A, Rowney M, Cohn JS. 2009. Dietary phospholipid-rich dairy milk extract reduces hepatomegaly, hepatic steatosis and hyperlipidemia in mice fed a high fat diet. Atherosclerosis, 205(1):144-150 https://doi.org/10.1016/j.atherosclerosis.2008.12.004
  34. Wang W, Goodman MT. 1999. Antioxidant property of dietary phenolic agents in human LDL-oxidation ex vivo model: interaction of protein binding activity. Nutr Res, 19(2):191-202 https://doi.org/10.1016/S0271-5317(98)00183-3
  35. Wei H, Cai Q, Raha RO. 1996. Inhibition of UV light and fenton induced oxidative DNA damage by the soybean isoflavone genistein caricinogenesis, 17(1):73-77 https://doi.org/10.1093/carcin/17.1.73
  36. Velasquez MT, Bhathema SJ. 2007. Role of dietary soy protein in obesity. Int J Med Sci, 4(2):72-82
  37. Yang JL. 2000. Antiatherogenic effect of chonkukjang. A thesis for the degree of doctor of philosophy. Pusan national university. pp 40-60
  38. Yoon HT. 2000. Isoflavone contents in soybean (glycine max (L. Merr) and the effects of soy-extract on enzyme activies and antioxidant. Ph D thesis. Donggnk Univ. pp 36-38
  39. Zhong F, Liu J, Ma J. Shoemaker CF. 2007. Preparation of hypocholesterol peptides from soy protein and their hypocholesterolemic effect in mice. Food Res Int, 40(6):661-667 https://doi.org/10.1016/j.foodres.2006.11.011

Acknowledgement

Supported by : 원광보건대학