DOI QR코드

DOI QR Code

Scoring System and Management Algorithm Assessing the Role of Survivin Expression in Predicting Progressivity of HPV Infections in Precancerous Cervical Lesions

  • Indarti, Junita ;
  • Aziz, M. Farid ;
  • Suryawati, Bethy ;
  • Fernando, Darrell
  • Published : 2013.03.30

Abstract

Background: To identify the risk factors and assess the role of survivin in predicting progessivity precancerous cervical lesions. Materials and Methods: This case-control study was conducted from October 2009 until May 2010. We obtained 74 samples, classified according to the degree of cervical intraepithelial neoplasia (CIN): 19 samples for CIN 1, 18 samples for CIN 2, 18 samples for CIN 3, and 19 samples as controls. Demographic profiles and risk factors assesment, histopathologic examination, HPV DNA tests, immunocytochemistry (ICC) and immunohistochemistry (IHC) staining for survivin expression were performed on all samples. Data was analyzed with bivariate and multivariate analysis. Results: Multivariate analysis revealed significant risk factors for developing precancerous cervical lesions are age <41 years, women with ${\geq}2$ sexual partners, course of education ${\geq}13$ years, use of oral contraceptives, positive high-risk HPV DNA, and high survivin expression by ICC or IHC staining. These factors were fit to a prediction model and we obtained a scoring system to predict the progressivity of CIN lesions. Conclusions: Determination of survivin expression by immunocytochemistry staining, along with other significant risk factors, can be used in a scoring system to predict the progressivity of CIN lesions. Application of this scoring system may be beneficial in determining the action of therapy towards the patient.

Keywords

Precancerous cervical lesions;cervical intraepithelial neoplasia;survivin;immunocytochemistry

References

  1. Almonte M, Ferreccio C, Gonzales M (2011). Risk factors for high-risk human papillomavirus infection and cofactors for high-grade cervical disease in Peru. Int J Gynecol Cancer, 21, 1654-63. https://doi.org/10.1097/IGC.0b013e3182288104
  2. American Cancer Society (2009). What Are the Risk Factors for Cervical Cancer? Available at http://www.cancer.org/cancer/cervicalcancer/detailedguide/cervical-cancer-risk-factors. Accessed July 14, 2010.
  3. Belinson S, Smith JS, Myers E, et al (2008). Descriptive evidence that risk profiles for cervical intraepithelial neoplasia 1, 2, and 3 are unique. Cancer Epidemiol Biomarkers Prev, 17, 2350-5. https://doi.org/10.1158/1055-9965.EPI-08-0004
  4. Barbosa LC, da Silva ID, Correa JC, Ribalta JC (2011). Survivin and telomerase expression in the uterine cervix of women with human papillomavirus-induced lesions. Int J Gynecol Cancer, 21, 15-21. https://doi.org/10.1097/IGC.0b013e318203d42b
  5. Bibbo M, Klump WJ, DeCecco J, Kovatich AJ (2002). Procedure for immunocytochemical detection of P16INK4A antigen in thin-layer, liquid-based specimens. Acta Cytol, 46, 25-9. https://doi.org/10.1159/000326711
  6. Boone JD, Erickson BK, Huh WK (2012). New insights to cervical cancer screening. J Gynecol Oncol, 23, 282-7. https://doi.org/10.3802/jgo.2012.23.4.282
  7. Borbely AA, Murvai M, Konya J et al (2006). Effects of human papillomavirus type 16 oncoproteins on survivin gene expression. J Gen Virol, 87, 287-94. https://doi.org/10.1099/vir.0.81067-0
  8. Branca M, Giorgi C, Santini D, et al (2005). Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer. Am J Clin Pathol, 124, 113-21. https://doi.org/10.1309/L8BWF431WU9AC8FJ
  9. Branca M, Ciotti M, Giorgi C et al (2008). Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling. Int J Gynecol Pathol, 27, 265-73.
  10. Castle PE, Cox JT, Schiffman M WC, Solomon D (2008). Factors influencing histologic confirmation of high-grade squamous intraepithelial lesion cytology. Obstet Gynecol, 112, 637-45. https://doi.org/10.1097/AOG.0b013e3181834637
  11. de Boer MA, Vet JN, Aziz MF et al (2006). Human papillomavirus type 18 and other risk factors for cervical cancer in Jakarta, Indonesia. Int J Gynecol Cancer, 16, 1809-14. https://doi.org/10.1111/j.1525-1438.2006.00701.x
  12. Engberts MK, Verbruggen BS, Boon ME, van Haaften M, Heintz AP (2007). Candida and dysbacteriosis: a cytologic, population-based study of 100,605 asymptomatic women concerning cervical carcinogenesis. Cancer, 111, 269-74. https://doi.org/10.1002/cncr.22947
  13. Gadducci A, Barsotti C, Cosio S, Domenici L, Riccardo GA (2011). Smoking habit, immune suppression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis: a review of the literature. Gynecol Endocrinol, 27, 597-604. https://doi.org/10.3109/09513590.2011.558953
  14. Gillet E, Meys JFA, Verstraelen H, et al (2012). Association between bacterial vaginosis and cervical intraepithelial neoplasia: systematic review and metaanalysis. PLoS One, 7, 45201. https://doi.org/10.1371/journal.pone.0045201
  15. Hellberg D, Stendahl U (2005). The biological role of smoking, oral contraceptive use and endogenous sexual steroid hormones in invasive squamous epithelial cervical cancer. Anticancer Res, 25, 3041-6.
  16. Jensen KE, Schmiedel S, Norrild B et al (2013). Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up. Br J Cancer, 108, 234-9. https://doi.org/10.1038/bjc.2012.513
  17. Kim JW, Song SH, Jin CH, et al (2012). Factors affecting the clearance of high-risk human papillomavirus infection and the progression of cervical intraepithelial neoplasia. J Int Med Res, 40, 486-96. https://doi.org/10.1177/147323001204000210
  18. Kim K, Kim JJ, Kim SM, No JH, Kim YB (2012). Prevalence and determinants of high-risk human papillomavirus infection in women with high socioeconomic status in Seoul, Republic of Korea. Asian Pac J Cancer Prev, 13, 269-73. https://doi.org/10.7314/APJCP.2012.13.1.269
  19. Li F (2005). Role of survivin and its splice variants in tumorigenesis. Br J Cancer, 92, 212-6.
  20. Mita AC, Mita MM, Nawrocki ST, Giles FJ (2008). Survivin:key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin Cancer Res, 14, 5000-5. https://doi.org/10.1158/1078-0432.CCR-08-0746
  21. Poomtavorn Y, Suwannarurk K, Thaweekul Y, Maireang K (2011). Risk factors for high-grade cervical intraepithelial neoplasia in patients with atypical squamous cells of undetermined significance (ASC-US) Papanicolaou smears. Asian Pac J Cancer Prev, 12, 235-8.
  22. Roeters AM, Boon ME, van Haaften M, et al (2010). Inflammatory events as detected in cervical smears and squamousintraepithelial lesions. Diagn Cytopathol, 38, 85-93.
  23. Tan GC, Norlatiffah S, Sharifah NA et al (2010). Immunohistochemical study of p16 INK4A and survivin expressions in cervical squamous neoplasm. Indian J Pathol Microbiol, 53, 1-6. https://doi.org/10.4103/0377-4929.59173
  24. WHO/ICO Information Centre on HPV and Cervical Cancer (HPV Information Centre) (2010). Human Papillomavirus and Related Cancers in Indonesia. Summary Report 2010. Accessed 5 February 2013.

Cited by

  1. MEKK3 and Survivin Expression in Cervical Cancer: Association with Clinicopathological Factors and Prognosis vol.15, pp.13, 2014, https://doi.org/10.7314/APJCP.2014.15.13.5271
  2. Differencies in Risk Factors for Cervical Dysplasia with the Applied Diagnostic Method in Serbia vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6697
  3. Application of Tumor Markers SCC-Ag, CEA, and TPA in Patients with Cervical Precancerous Lesions vol.15, pp.9, 2014, https://doi.org/10.7314/APJCP.2014.15.9.3911
  4. Smoking cessation leads to changes in survivin expression in oral mucosa pp.09042512, 2017, https://doi.org/10.1111/jop.12664

Acknowledgement

Supported by : University of Indonesia