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Effect of Red Ginseng Saponin Fraction on the Blood Components of Male Guinea Pigs with Acute Toxicity induced by 2,3,7,8-Tetracholorodibenzo-ρ-dioxin (TCDD)

홍삼의 사포닌이 다이옥신에 의한 급성독성 유도 웅성 기니피그의 혈액성분에 미치는 영향

  • Kim, Byung-Weon (Dept. of Biomedical Laboratory Science, Gimcheon University) ;
  • Lee, Yoon-Bok (Dept. of Central Research Institute, Chung's Food Co. LTD.) ;
  • Park, Jae-Seung (Dept. of Biomedical Laboratory Science, Sohae University) ;
  • Park, Ji-Won (Dept. of Medical Management, Gimcheon University) ;
  • Hwang, Seock-Yeon (Dept. of Biomedical Laboratory Science, Daejeon University)
  • 김병원 (김천대학교 임상병리학과) ;
  • 이윤복 ((주)정식품 중앙연구소) ;
  • 박재승 (서해대학교 임상병리과) ;
  • 박지원 (김천대학교 의료경영학과) ;
  • 황석연 (대전대학교 임상병리학과)
  • Received : 2013.03.09
  • Accepted : 2013.04.20
  • Published : 2013.04.28

Abstract

The decreased body, liver, kidney, spleen and testis weights of guinea pigs by TCDD (2,3,7,8-tetracholorodibenzo-${\rho}$-dioxin) treatment (TT) were statistically significantly increased after treating red ginseng saponin fraction (SF) (p>0.01). After treated with SF, the decreased hematocrits values and numbers of RBC and platelet, activity of amylase and lactate dehydrogenase, levels of uric acid, total protein and albumin by TT were increased, and the increased numbers of WBC, levels of triglyceride, total cholesterol (TC), LDL-cholesterol, HDL-cholesterol, creatinine, blood urea nitrogen, calcium and phosphorus, activities of creatinine kinase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were decreased after treated with SF. And they all had a statistical significance (p>0.01) except for RBC, WBC, platelet, blood glucose, TC, calcium and albumin. From these results, we knew that SF mollified the acute toxicity induced by TCDD in guinea pigs.

Keywords

2,3,7,8-Tetrachlorodibenzo-ρ-dioxin (TCDD);Saponin fraction;Liver toxicity protection;Blood components

Acknowledgement

Supported by : 농림수산식품부