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Skeletal-Related Events among Breast and Prostate Cancer Patients: Towards New Treatment Initiation in Malaysia's Hospital Setting

  • Ezat, Sharifa Wan Puteh (Department of Community Health, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Junid, Syed Mohamed Aljunid Syed (United Nations University-International Institute for Global Health) ;
  • Khamis, Noraziani (Department of Community Health, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Ahmed, Zafar (International Centre for Casemix and Clinical Coding, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Sulong, Saperi (International Centre for Casemix and Clinical Coding, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Nur, Amrizal Muhammad (International Centre for Casemix and Clinical Coding, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Aizuddin, Azimatun Noor (Department of Community Health, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Ismail, Fuad (Department of Oncology and Radiotherapy, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Abdullah, Norlia (Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Zainuddin, Zulkifli Md (Urology Unit, Department of Surgery, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Kassim, Abdul Yazid Mohd (Department of Orthopaedic and Traumatology, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Haflah, Nor Hazla Mohamed (Department of Orthopaedic and Traumatology, Universiti Kebangsaan Malaysia Medical Centre)
  • Published : 2013.05.30

Abstract

The human skeleton is the most common organ to be affected by metastatic cancer and bone metastases are a major cause of cancer morbidity. The five most frequent cancers in Malaysia among males includes prostate whereas breast cancer is among those in females, both being associated with skeletal lesions. Bone metastases weaken bone structure, causing a range of symptoms and complications thus developing skeletal-related events (SRE). Patients with SRE may require palliative radiotherapy or surgery to bone for pain, having hypercalcaemia, pathologic fractures, and spinal cord compression. These complications contribute to a decline in patient healthrelated quality of life. The multidimensional assessment of health-related quality of life for those patients is important other than considering a beneficial treatment impact on patient survival, since the side effects of treatment and disease symptoms can significantly impact health-related quality of life. Cancer treatment could contribute to significant financial implications for the healthcare system. Therefore, it is essential to assess the health-related quality of life and treatment cost, among prostate and breast cancer patients in countries like Malaysia to rationalized cost-effective way for budget allocation or utilization of health care resources, hence helping in providing more personalized treatment for cancer patients.

Keywords

Skeletal related events;bone metastases;quality of life;breast cancer;prostate cancer;cost

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