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Associations of CYP1A1, GSTM1 and GSTT1 Polymorphisms with Lung Cancer Susceptibility in a Northern Indian Population

  • Shukla, R.K. (King George's Medical University) ;
  • Tilak, A.R. (Environmental Biotechnology, Indian Institute of Toxicology Research) ;
  • Kumar, C. (King George's Medical University) ;
  • Kant, S. (King George's Medical University) ;
  • Kumar, A. (Environmental Biotechnology, Indian Institute of Toxicology Research) ;
  • Mittal, B. (Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences) ;
  • Bhattacharya, S. (King George's Medical University)
  • Published : 2013.05.30

Abstract

Background: Susceptibility to lung cancer has been shown to be modulated by inheritance of polymorphic genes encoding cytochrome P450 1A1 (CYP1A1) and glutathione S transferases (GSTM1 and GSTT1), which are involved in the bioactivation and detoxification of environmental toxins. This might be a factor in the variation in lung cancer incidence with ethnicity. Materials and Methods: We conducted a case-control study of 218 northern Indian lung cancer patients along with 238 healthy controls, to assess any association between CYP1A1, GSTM1 and GSTT1 polymorphisms, either separately or in combination, with the likelihood of development of Lung cancer in our population. Results: We observed a significant difference in the GSTT1 null deletion frequency in this population when compared with other populations (OR=1.87, 95%CI: 1.25-2.80-0.73, P=0.002). However, GSTM1 null genotype was found associated with lung cancer in the non-smoking subgroup. (P=0.170). Conclusions: Our study showed the GSTT1 null polymorphism to be associated with smoking-induced lung cancer and the GSTM1 null polymorphism to have a link with non-smoking related lung cancer.

Keywords

Lung cancer;genetic polymorphism;CYP1A1;GSTM1;GSTT1;odds ratio;smoking

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