- Volume 14 Issue 5
DOI QR Code
Associations of CYP1A1, GSTM1 and GSTT1 Polymorphisms with Lung Cancer Susceptibility in a Northern Indian Population
- Shukla, R.K. (King George's Medical University) ;
- Tilak, A.R. (Environmental Biotechnology, Indian Institute of Toxicology Research) ;
- Kumar, C. (King George's Medical University) ;
- Kant, S. (King George's Medical University) ;
- Kumar, A. (Environmental Biotechnology, Indian Institute of Toxicology Research) ;
- Mittal, B. (Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences) ;
- Bhattacharya, S. (King George's Medical University)
- Published : 2013.05.30
Background: Susceptibility to lung cancer has been shown to be modulated by inheritance of polymorphic genes encoding cytochrome P450 1A1 (CYP1A1) and glutathione S transferases (GSTM1 and GSTT1), which are involved in the bioactivation and detoxification of environmental toxins. This might be a factor in the variation in lung cancer incidence with ethnicity. Materials and Methods: We conducted a case-control study of 218 northern Indian lung cancer patients along with 238 healthy controls, to assess any association between CYP1A1, GSTM1 and GSTT1 polymorphisms, either separately or in combination, with the likelihood of development of Lung cancer in our population. Results: We observed a significant difference in the GSTT1 null deletion frequency in this population when compared with other populations (OR=1.87, 95%CI: 1.25-2.80-0.73, P=0.002). However, GSTM1 null genotype was found associated with lung cancer in the non-smoking subgroup. (P=0.170). Conclusions: Our study showed the GSTT1 null polymorphism to be associated with smoking-induced lung cancer and the GSTM1 null polymorphism to have a link with non-smoking related lung cancer.
- Bethesda M (2001). SEER Cancer Statistics Review. National Institutes of Health 1973-1998.
- Chan-Yeung M, Tan-Un KC, Ip MS, et al (2004). Lung cancer susceptibility and polymorphisms of glutathione-Stransferase genes in Hong Kong. Lung Cancer, 45, 155-60. https://doi.org/10.1016/j.lungcan.2004.01.016
- Chen H, Sandler DP, Taylor JA, et al (1996). Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect. Lancet, 347, 295-7. https://doi.org/10.1016/S0140-6736(96)90468-7
- Deutsch-Wenzel RP, Brune H, Grimmer G, Dettbarn G, Misfeld J (1983). Experimental studies in rat lungs on the carcinogenicity and dose-response relationships of eight frequently occurring environmental polycyclic aromatic hydrocarbons. J Natl Cancer Inst, 71, 539-44.
- Gao Y, Zhang Q (1999). Polymorphisms of the GSTM1 and CYP2D6 genes associated with susceptibility to lung cancer in Chinese. Mutat Res, 444, 441-9. https://doi.org/10.1016/S1383-5718(99)00092-3
- Garte S, Boffetta P, Caporaso N, Vineis P (2001). Metabolic gene allele nomenclature. Cancer Epidemiol Biomarkers Prev, 10, 1305-6.
- Gonzalez FJ (1990). Molecular genetics of the P-450 superfamily. Pharmacol Ther, 45, 1-38. https://doi.org/10.1016/0163-7258(90)90006-N
- Guengerich FP, Thier R, Persmark M, et al (1995). Conjugation of carcinogens by theta class glutathione s-transferases: mechanisms and relevance to variations in human risk. Pharmacogenetics, 5, 103-7. https://doi.org/10.1097/00008571-199504000-00007
- Hayes JD, Pulford DJ (1995). The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol, 30, 445-600. https://doi.org/10.3109/10409239509083491
- Ingelman-Sundberg M, Oscarson M, Daly AK, Garte S, Nebert DW (2001). Human cytochrome P-450 (CYP) genes: a web page for the nomenclature of alleles. Cancer Epidemiol Biomarkers Prev, 10, 1307-8.
- Kawajiri K, Nakachi K, Imai K, et al (1990). Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene. FEBS Lett. 263, 131-3. https://doi.org/10.1016/0014-5793(90)80721-T
- Ketterer B, Harris JM, Talaska G, et al (1992). The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer. Environ Health Perspect, 98, 87-94. https://doi.org/10.1289/ehp.929887
- Lan Q, He X, Costa DJ, et al (2000). Indoor coal combustion emissions, GSTM1 and GSTT1 genotypes, and lung cancer risk: a case-control study in Xuan Wei, China. Cancer Epidemiol Biomarkers Prev, 9, 605-8.
- Meldrum M, Rawbone R, Curran AD, Fishwick D (2005). The role of occupation in the development of chronic obstructive pulmonary disease (COPD). Occup Environ Med, 62, 212-4. https://doi.org/10.1136/oem.2004.015511
- Miller SA, Dykes DD, Polesky HF (1988). A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res, 16, 1215. https://doi.org/10.1093/nar/16.3.1215
- Mishra DK, Kumar A, Srivastava DS, Mittal RD (2004). Allelic variation of GSTT1, GSTM1 and GSTP1 genes in North Indian population. Asian Pac J Cancer Prev, 5, 362-5.
- Naveen AT, Adithan C, Padmaja N, et al (2004). Glutathione S-transferase M1 and T1 null genotype distribution in South Indians. Eur J Clin Pharmacol, 60, 403-6.
- Nelson HH, Wiencke JK, Christiani DC, et al (1995). Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta. Carcinogenesis, 16, 1243-5. https://doi.org/10.1093/carcin/16.5.1243
- Perera FP (1998). Molecular epidemiology of environmental carcinogenesis. Recent Results Cancer Res, 154, 39-46. https://doi.org/10.1007/978-3-642-46870-4_3
- Persson I, Johansson I, Lou YC, et al (1999). Genetic polymorphism of xenobiotic metabolizing enzymes among Chinese lung cancer patients. Int J Cancer, 81, 325-9. https://doi.org/10.1002/(SICI)1097-0215(19990505)81:3<325::AID-IJC2>3.0.CO;2-S
- Raunio H, Husgafvel-Pursiainen K, Anttila S, et al (1995). Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility-a review. Gene, 159, 113-21. https://doi.org/10.1016/0378-1119(94)00448-2
- Roy B, Majumder PP, Dey B, et al (2001). Ethnic differences in distributions of GSTM1 and GSTT1 homozygous “null” genotypes in India. Hum Biol, 73, 443-50. https://doi.org/10.1353/hub.2001.0040
- Setiawan VW, Zhang ZF, Yu GP, et al (2000). GSTT1 and GSTM1 null genotypes and the risk of gastric cancer: a case-control study in a Chinese population. Cancer Epidemiol Biomarkers Prev, 9, 73-80.
- Sobti RC, Sharma S, Joshi A, Jindal SK, Janmeja A (2004). Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population. Mol Cell Biochem, 266, 1-9. https://doi.org/10.1023/B:MCBI.0000049127.33458.87
- Sorensen M, Autrup H, Tjonneland A, et al (2004). Glutathione S-transferase T1 null-genotype is associated with an increased risk of lung cancer. Int J Cancer, 110, 219-24. https://doi.org/10.1002/ijc.20075
- Sreeja L, Syamala V, Hariharan S, et al (2005). Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population. J Hum Genet, 50, 618-27. https://doi.org/10.1007/s10038-005-0303-3
- Taioli E, Ford J, Trachman J, et al (1998). Lung cancer risk and CYP1A1 genotype in African Americans. Carcinogenesis, 19, 813-7. https://doi.org/10.1093/carcin/19.5.813
- Taningher M, Malacarne D, Izzotti A, Ugolini D, Parodi S (1999). Drug metabolism polymorphisms as modulators of cancer susceptibility. Mutat Res, 436, 227-61. https://doi.org/10.1016/S1383-5742(99)00005-8
- Susceptibility of Lung Cancer with Polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 Genotypes in the Population of Inner Mongolia Region vol.15, pp.13, 2014, https://doi.org/10.7314/APJCP.2014.15.13.5207
- GSTM1 Polymorphisms and Lung Cancer Risk in the Chinese Population: a Meta-Analysis Based on 47 Studies vol.15, pp.18, 2014, https://doi.org/10.7314/APJCP.2014.15.18.7741
- The Associations between Two Vital GSTs Genetic Polymorphisms and Lung Cancer Risk in the Chinese Population: Evidence from 71 Studies vol.9, pp.7, 2014, https://doi.org/10.1371/journal.pone.0102372
- Epidermal Growth Factor Receptor Mutations in Japanese Men with Lung Adenocarcinomas vol.15, pp.24, 2015, https://doi.org/10.7314/APJCP.2014.15.24.10627
- Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India vol.16, pp.16, 2015, https://doi.org/10.7314/APJCP.2015.16.16.6953
- Immunohistochemical Expression of Cytokeratins and Epithelial Membrane Protein 2 in Nasopharyngeal Carcinoma and its Potential Implications vol.16, pp.2, 2015, https://doi.org/10.7314/APJCP.2015.16.2.653
- Assessment of Perception of Medical Students in Regard to Links between Tobacco or Alcohol Use and Cancer vol.16, pp.7, 2015, https://doi.org/10.7314/APJCP.2015.16.7.2697
- Meta-Analysis of the Association between the rs8034191 Polymorphism in AGPHD1 and Lung Cancer Risk vol.16, pp.7, 2015, https://doi.org/10.7314/APJCP.2015.16.7.2713
- CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case–control study vol.15, pp.2, 2016, https://doi.org/10.1007/s10689-015-9849-1
- Pharmacophore Development for Anti-Lung Cancer Drugs vol.16, pp.18, 2016, https://doi.org/10.7314/APJCP.2015.16.18.8307
- CYP1A1 MspI Polymorphism and Cervical Carcinoma Risk in the Multi-Ethnic Population of Malaysia: a Case-Control Study vol.17, pp.1, 2016, https://doi.org/10.7314/APJCP.2016.17.1.57
- Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta-analysis vol.58, pp.9, 2017, https://doi.org/10.1002/em.22149
- Metabolic Phase I (CYPs) and Phase II (GSTs) Gene Polymorphisms and Their Interaction with Environmental Factors in Nasopharyngeal Cancer from the Ethnic Population of Northeast India pp.1532-2807, 2017, https://doi.org/10.1007/s12253-017-0309-0
- Glutathione S-transferase M1 and T1 null genotype frequency distribution among four tribal populations of western India vol.97, pp.1, 2018, https://doi.org/10.1007/s12041-018-0888-x