- Volume 14 Issue 5
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The XRCC3 Thr241Met Polymorphism Influences Glioma Risk - A Meta-analysis
- Jiang, Jun (Radiation Oncology, The First Affiliated Hospital of Anhui Medical University) ;
- Quan, Xun-Feng (Radiation Oncology, The First Affiliated Hospital of Anhui Medical University) ;
- Zhang, Li (Radiation Oncology, The First Affiliated Hospital of Anhui Medical University) ;
- Wang, Yi-Chun (Radiation Oncology, The First Affiliated Hospital of Anhui Medical University)
- Published : 2013.05.30
Background: Findings from previous published studies regarding the association of the XRCC3 Thr241Met polymorphism with glioma susceptibility have often been conflicting. Therefore, a meta-analysis including all available publications was carried out to make a more precise estimation of the potential relationship. Methods: By searching the electronic databases of Pubmed and Embase (up to April 1st, 2013), a total of nine case-control studies with 3,752 cases and 4,849 controls could be identified for inclusion in the current meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the association. Results: This meta-analysis showed the XRCC3 Thr241Met polymorphism to be significantly associated with decreased glioma risk in the allelic model (Met allele vs. Thr allele: OR= 0.708, 95%CI= 0.631-0.795). Moreover, we also observed a statistically significant association between the XRCC3 Thr241Met polymorphism and reduced glioma risk in analyses stratified by ethnicity (Asian) and source of controls (hospital based) in the allelic model. Conclusions: Current evidence suggests that the XRCC3 Thr241Met polymorphism may be a risk factor for glioma development, especially in Asians.
- Abdel-Rahman SZ, El-Zein RA (2011). Evaluating the effects of genetic variants of DNA repair genes using cytogenetic mutagen sensitivity approaches. Biomarkers, 16, 393-404. https://doi.org/10.3109/1354750X.2011.577237
- Begg CB , Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101. https://doi.org/10.2307/2533446
- Bondy ML, Scheurer ME, Malmer B, et al (2008). Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer, 113, 1953-68. https://doi.org/10.1002/cncr.23741
- Custodio AC, Almeida LO, Pinto GR, et al (2012). Variation in DNA repair gene XRCC3 affects susceptibility to astrocytomas and glioblastomas. Genet Mol Res, 11, 332-9. https://doi.org/10.4238/2012.February.10.4
- DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
- Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
- Griffin CS, Simpson PJ, Wilson CR, et al (2000). Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation. Nat Cell Biol, 2, 757-61. https://doi.org/10.1038/35036399
- Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
- Jacobs DI, Bracken MB (2012). Association between XRCC1 polymorphism 399 G->A and glioma among Caucasians: a systematic review and meta-analysis. BMC Med Genet., 13, 97.
- Jemal A, Siegel R, Ward E, et al (2009). Cancer statistics. CA Cancer J Clin, 59, 225-49. https://doi.org/10.3322/caac.20006
- Kiuru A, Lindholm C, Heinavaara S, et al (2008). XRCC1 and XRCC3 variants and risk of glioma and meningioma. J Neurooncol, 88, 135-42. https://doi.org/10.1007/s11060-008-9556-y
- Kiyohara C, Takayama K, Nakanishi Y (2006). Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: a meta-analysis. Lung Cancer, 54, 267-83. https://doi.org/10.1016/j.lungcan.2006.08.009
- Liu HB, Peng YP, Dou CW, et al (2012). Comprehensive study on associations between nine SNPs and glioma risk. Asian Pac J Cancer Prev, 13, 4905-8. https://doi.org/10.7314/APJCP.2012.13.10.4905
- Liu YH, Scheurer ME, El-Zein R, et al (2009). Association and Interactions between DNA Repair Gene Polymorphisms and Adult Glioma. Epidemiol Biomarkers Prev, 18, 204-14. https://doi.org/10.1158/1055-9965.EPI-08-0632
- Lopez-Cima MF, Gonzalez-Arriaga P, Garcia-Castro L, et al (2007). Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain. BMC Cancer, 7, 162. https://doi.org/10.1186/1471-2407-7-162
- Louis DN, Ohgaki H, Wiestler OD, et al (2007). The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol, 114, 97-109. https://doi.org/10.1007/s00401-007-0243-4
- Luo KQ, Mu SQ, Wu ZX, et al (2013). Polymorphisms in DNA repair genes and risk of glioma and meningioma. Asian Pac J Cancer Prev, 14, 449-52. https://doi.org/10.7314/APJCP.2013.14.1.449
- Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
- Matullo G, Dunning AM, Guarrera S, et al (2006). DNA repair polymorphisms and cancer risk in non- smokers in a cohort study. Carcinogenesis, 27, 997-1007. https://doi.org/10.1093/carcin/bgi280
- Mittal RD, Gangwar R, Mandal RK, et al (2012). Gene variants of XRCC4 and XRCC3 and their association with risk for urothelial bladder cancer. Mol Biol Rep, 39, 1667-75. https://doi.org/10.1007/s11033-011-0906-z
- Pan WR, Li G, Guan JH(2013). Polymorphisms in DNA repair genes and susceptibility to glioma in a chinese population. Int J Mol Sci, 14, 3314-24. https://doi.org/10.3390/ijms14023314
- Rajaraman P, Hutchinson A, Wichner S, et al (2010). DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Neuro Oncol, 12, 37-48. https://doi.org/10.1093/neuonc/nop012
- Romanowicz-Makowska H, Brys M, Forma E, et al (2012). Single nucleotide polymorphism (SNP) Thr241Met in the XRCC3 gene and breast cancer risk in Polish women. Pol J Pathol, 63, 121-5.
- Saadat M, Ansari-Lari M (2009). Polymorphism of XRCC1 (at codon 399) and susceptibility to breast cancer, a metaanalysis of the literatures. Breast Cancer Res Treat, 115, 137-44. https://doi.org/10.1007/s10549-008-0051-0
- Schwartzbaum JA, Fisher JL, Aldape KD, et al (2006). Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol, 2, 494-503 (quiz 491 p following 516).
- Shen MR, Jones IM, Mohrenweiser H (1998). Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res, 58, 604-8.
- Takanami T, Nakamura J, Kubota Y, et al (2005). The Arg280His polymorphism in X-ray repair cross-complementing gene 1 impairs DNA repair ability. Mutat Res, 582, 135-45. https://doi.org/10.1016/j.mrgentox.2005.01.007
- Wang LE, Bondy ML, Shen HB, et al (2004). Polymorphisms of DNA Repair Genes and Risk of Glioma. Cancer Res, 64, 5560-3. https://doi.org/10.1158/0008-5472.CAN-03-2181
- Zhao Y, Deng X, Wang Z, et al (2012). Genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population. Asian Pac J Cancer Prev, 13, 665-9. https://doi.org/10.7314/APJCP.2012.13.2.665
- Zhou KK, Liu Yh, Zhang HS, et al (2009). XRCC3 haplotypes and risk of gliomas in a Chinese population: A hospital-based case-control study. Int J Cancer, 124, 2948-53. https://doi.org/10.1002/ijc.24307
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