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The Methylenetetrahydrofolate Reductase C677T Polymorphism Influences Risk of Esophageal Cancer in Chinese

  • Qu, Hong-Hong (Department of Epidemiology and Biostatistics, College of Public Health) ;
  • Cui, Li-Hong (Digestive System Department, PLA Navy General Hospital) ;
  • Wang, Ke (Department of Epidemiology and Biostatistics, College of Public Health) ;
  • Wang, Peng (Department of Epidemiology and Biostatistics, College of Public Health) ;
  • Song, Chun-Hua (Department of Epidemiology and Biostatistics, College of Public Health) ;
  • Wang, Kai-Juan (Department of Epidemiology and Biostatistics, College of Public Health) ;
  • Zhang, Jian-Ying (Department of Epidemiology and Biostatistics, College of Public Health) ;
  • Dai, Li-Ping (Department of Epidemiology and Biostatistics, College of Public Health)
  • Published : 2013.05.30

Abstract

Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism. This study with 381 esophageal cancer patients and 432 healthy controls was conducted to examine the association of MTHFR C677T and A1298C polymorphisms with susceptibility to esophageal cancer (EC) in a Chinese population. Compared with the CC genotype of MTHFR C677T, subjects carrying homozygote TT and variant genotypes (CT+TT) demonstrated reduced risk of EC with adjusted ORs (95% CI) of 0.44 (0.28-0.71) and 0.57 (0.37-0.88), respectively. However, no association was found between the MTHFR A1298C polymorphism and the risk of EC. Comparing to haplotype CA, haplotypes TA and TC could reduce the susceptibility to EC with adjusted ORs (95% CI) of 0.61(0.47-0.79) and 0.06 (0.01-0.43), respectively. In conclusion, the present study suggested that the MTHFR C677T polymorphism can markedly influence the risk of EC in Chinese.

Keywords

Esophageal cancer;polymorphism;MTHFR;susceptibility;interaction

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  2. Combined genotype and haplotype distributions of MTHFR C677T and A1298C polymorphisms vol.95, pp.48, 2016, https://doi.org/10.1097/MD.0000000000005355