- Volume 14 Issue 5
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Protective Effects of -Paradol on Histological Lesions and Immunohistochemical Gene Expression in DMBA Induced Hamster Buccal Pouch Carcinogenesis
- Mariadoss, Arokia Vijayaanand (Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University) ;
- Kathiresan, Suresh (Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University) ;
- Muthusamy, Rajasekar (Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University) ;
- Kathiresan, Sivakumar (Department of Botany, Faculty of Science, Annamalai University)
- Published : 2013.05.30
Background: The search for naturally occurring agents in routinely consumed foods that may inhibit cancer development is of high priority. -Paradol is a pungent phenolic bioactive component from ginger with welldocumented health promoting antioxidant, antimutagenic, antigenotoxic and anti-inflammatory properties. However, anticarcinogenic effects have yet to be fully explored. The objectives of the present study were therefore to assess protective effects against 7,12-dimethylbenz(a)anthracene (DMBA) induced buccal pouch carcinogenesis in male golden Syrian hamsters. Methods: Oral squamous cell carcinomas developed in the left buccal pouch of hamsters on painting with 0.5% of DMBA, three times in a week. To assess the apoptotic associated gene expressing potential of -paradol, it was orally administered to DMBA treated hamsters on alternate days from DMBA painting for 14 weeks. Results: We observed 100% tumor formation with marked levels of neoplastic changes and altered the expression of apoptotic associated gene (p53, bcl-2, caspase-3 and TNF-
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