Obesity and Risk of Bladder Cancer: A Meta-analysis of Cohort Studies

  • Qin, Qi (Department of General Surgery, Childrens Hospital, Zhejiang University School of Medicine) ;
  • Xu, Xin (Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine) ;
  • Wang, Xiao (Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine) ;
  • Zheng, Xiang-Yi (Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine)
  • 발행 : 2013.05.30


Objective: Previous epidemiologic studies demonstrated that obesity might associated with the risk of bladder cancer. However, many of the actual association findings remained conflicting. To better clarify and provide a comprehensive summary of the correlation between obesity and bladder cancer risk, we conducted a meta-analysis to summarize results of studies on the issue. Stratified analyses were also performed on potential variables and characteristics. Methods: Studies were identified by searching in PubMed and Wanfang databases, covering all the papers published from their inception to March 10, 2013. Summary relative risks (SRRs) with their corresponding 95% confidence intervals (CIs) were calculated by either random-effect or fixed-effect models. Results: A total of 11 cohort studies were included in our meta-analysis, which showed that obesity was associated with an increased risk for bladder cancer in all subjects (RR=1.10, 95% CI=1.06-1.16; p=0.215 for heterogeneity; $I^2$=24.0%). Among the 9 studies that controlled for cigarette smoking, the pooled RR was 1.09 (95% CI 1.01-1.17; p=0.131 for heterogeneity; $I^2$=35.9%). No significant publication bias was detected (p = 0.244 for Egger's regression asymmetry test). Conclusions: Our results support the conclusion that obesity is associated with the increased risk of bladder cancer. Further research is needed to generate a better understanding of the correlation and to provide more convincing evidence for clinical intervention in the prevention of bladder cancer.


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