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Susceptibility Loci Associations with Prostate Cancer Risk in Northern Chinese Men

  • Wang, Na-Na (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Xu, Yong (Department of Urology, The Second Hospital of Tianjin Medical University) ;
  • Yang, Kuo (Department of Urology, The Second Hospital of Tianjin Medical University) ;
  • Wei, Dong (Department of Urology and Beijing Hospital, Chinese Ministry of Health) ;
  • Zhang, Yao-Guang (Peking Union Medical College and Chinese Academy of Medical Sciences, Graduate School) ;
  • Liu, Ming (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Shi, Xiao-Hong (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Liang, Si-Ying (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Sun, Liang (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Zhu, Xiao-Quan (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Yang, Yi-Ge (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Tang, Lei (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Zhao, Cheng-Xiao (Peking Union Medical College and Chinese Academy of Medical Sciences, Graduate School) ;
  • Wang, Xin (Peking Union Medical College and Chinese Academy of Medical Sciences, Graduate School) ;
  • Chen, Xin (Peking Union Medical College and Chinese Academy of Medical Sciences, Graduate School) ;
  • Hui, Juan (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Zhang, Yu-Hong (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Zhu, Ling (Physical Examination Centre, Beijing Hospital, Ministry of Health) ;
  • Yang, Fan (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Zhang, Yu-Rong (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Yang, Ze (The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health) ;
  • Wang, Jian-Ye (Department of Urology and Beijing Hospital, Chinese Ministry of Health)
  • Published : 2013.05.30

Abstract

Background: KLK3 gene products, like human prostate-specific antigen (PSA), are important biomarkers in the clinical diagnosis of prostate cancer (PCa). G protein-coupled receptor RFX6, C2orf43 and FOXP4 signaling plays important roles in the development of PCa. However, associations of these genes with PCa in northern Chinese men remain to be detailed. This study aimed to investigate their impact on occurrence and level of malignancy. Methods: All subjects were from Beijing and Tianjin, including 266 cases with prostate cancer and 288 normal individuals as controls. We evaluated associations between clinical covariates (age at diagnosis, prostate specific antigen, Gleason score, tumor stage and aggressive) and 6 candidate PCa risk loci, genotyped by PCR- high resolution melting curve and sequencing methods. Results: Case-control analysis of allelic frequency of PCa associated with PCa showed that one of the 6 candidate risk loci, rs339331 in the RFX6 gene, was associated with reduced risk of prostate cancer (odds ratio (OR) = 0.73, 95% confidence interval (CI) =0.57-0.94, P = 0.013) in northern Chinese men. In addition, subjects with CX (CC+TC) genotypes had a decreased risk for prostrate cancer compared to those carrying the TT homozygote (OR =0.64, 95% CI = 0.45- 0.90, P = 0.008). The TT genotype of 13q22 (rs9600079, T) was associated with tumor stage (P=0.044, OR=2.34, 95% CI=0.94-5.87). Other SNPs were not significantly associated with clinical covariates in prostate cancer (P > 0.05). Conclusions. rs339331 in the RFX6 gene may be associated with prostate cancer as a susceptibility locus in northern Chinese men.

Keywords

prostate cancer;association;northern Chinese men;genetic variants

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