- Volume 14 Issue 5
DOI QR Code
Application of Human Papillomavirus in Screening for Cervical Cancer and Precancerous Lesions
- Wang, Jin-Liang (Department of General Oncology, Chinese PLA General Hospital) ;
- Yang, Yi-Zhuo (Department of Obstetrics and Gynecology, Chinese PLA General Hospital) ;
- Dong, Wei-Wei (Department of General Oncology, Chinese PLA General Hospital) ;
- Sun, Jing (Department of Obstetrics and Gynecology, Chinese PLA General Hospital) ;
- Tao, Hai-Tao (Department of General Oncology, Chinese PLA General Hospital) ;
- Li, Rui-Xin (Department of General Oncology, Chinese PLA General Hospital) ;
- Hu, Yi (Department of General Oncology, Chinese PLA General Hospital)
- Published : 2013.05.30
Cervical cancer is a commonly-encountered malignant tumor in women. Cervical screening is particularly important due to early symptoms being deficient in specificity. The main purpose of the study is to assess the application value of cervical thinprep cytologic test (TCT) and human papillomavirus (HPV) detection in screening for cervical cancer and precancerous lesions. In the study, cervical TCT and HPV detection were simultaneously performed on 12,500 patients selected in a gynecological clinic. Three hundred patients with positive results demonstrated by cervical TCT and/or HPV detection underwent cervical tissue biopsy under colposcopy, and pathological results were considered as the gold standard. The results revealed that 200 out of 12,500 patients were abnormal by TCT, in which 30 cases pertained to equivocal atypical squamous cells (ASCUS), 80 cases to low squamous intraepithelial lesion (LSIL), 70 cases to high squamous intraepithelial lesion (HSIL) and 20 cases to squamous cell carcinoma (SCC). With increasing pathological grade of cervical biopsy, however, TCT positive rates did not rise. Two hundred and eighty out of 12,500 patients were detected as positive for HPV infection, in which 50 cases were chronic cervicitis and squamous metaplasia, 70 cases cervical intraepithelial neoplasia (CIN) I, 60 cases CIN II, 70 cases CIN III and 30 cases invasive cervical carcinoma. Two hundred and thirty patients with high-risk HPV infection were detected. With increase in pathological grade, the positive rate of high-risk HPV also rose. The detection rates of HPV detection to CIN III and invasive cervical carcinoma as well as the total detection rate of lesions were significantly higher than that of TCT. Hence, HPV detection is a better method for screening of cervical cancer at present.
Cervical thinprep cytology test;human papillomavirus;colposcopy;screening;cervical cancer
- Balbi G, Napolitano A, Giordano F, et al (2012). Role of the association of high-risk HPV identified by real-time PCR in cervical preneoplastic lesions. Eur J Gynaecol Oncol, 33, 467-71.
- Berois N, De Cremoux P, Mazal D, et al (2013). Prevalence and distribution of high-risk human papillomavirus genotypes in invasive carcinoma of the uterine cervix in Uruguay. Int J Gynecol Cancer, 23, 527-32. https://doi.org/10.1097/IGC.0b013e318285e753
- Bolgova LS, Tuganova TN, Alekseenko OI (2012). The cytological diagnostics of dysplasia and epidermoid carcinoma of the cervix in studying the nucleolar-organizing regions of chromosomes. Klin Lab Diagn, 11, 36-41.
- Canadian Task Force on Preventive Health Care, Pollock S, Dunfield L, et al (2013). Recommendations on screening for cervical cancer. CMAJ, 185, 35-45. https://doi.org/10.1503/cmaj.121505
- Corcoran J, Dattalo P, Crowley M (2012). Cervical cancer screening interventions for U.S. Latinas: a systematic review. Health Soc Work, 37, 197-205. https://doi.org/10.1093/hsw/hls035
- Croswell J, Costello A (2012). Screening for cervical cancer. Am Fam Physician, 86, 563-4.
- Ding L, Zou XJ, Ao JE, et al (2008). ELISA test to detect CDKN2A (p16(INK4a)) expression in exfoliative cells: a new screening tool for cervical cancer. Mol Diagn Ther, 12, 395-400. https://doi.org/10.1007/BF03256305
- Dollin J (2013). Preventing cervical cancer: beyond following guidelines. CMAJ, 185, 13-4. https://doi.org/10.1503/cmaj.121781
- Galarowicz B, Jach R, Kidzierska J, et al (2012). The role of mRNA E6/E7 HPV high oncogenic risk expression in colposcopy of cervical intraepithelial neoplasia (CIN). Przegl Lek, 69, 651-7.
- Gerli S, Bavetta F, Di Renzo GC (2012). Antisepsis regimen in the surgical treatment of HPV generated cervical lesions: polyhexamethylene biguanide vs chlorhexidine. A randomized, double blind study. Eur Rev Med Pharmacol Sci, 16, 1994-8.
- Giraldi G, De Luca d'Alessandro E (2012). The HPV infection in males: an update. Ann Ig, 24, 497-506.
- Jablonowska D, Marszalek A, Bodnar M (2012). Tabacco smoking, HPV infection and changes in cervix. Przegl Lek, 69, 740-3.
- Jach R, Posadzka E, Sliwińska A, et al (2012). The influence of surgery of cervical intraepithelial neoplasia (CIN) and cervical carcinoma on quality of life. Przegl Lek, 69, 647-50.
- Konno R (2013). Screening of uterine cervical neoplasms and HPV vaccine. Gan To Kagaku Ryoho, 40, 165-9.
- Li J, Kang LN, Qiao YL (2011). Review of the cervical cancer disease burden in mainland China. Asian Pac J Cancer Prev, 12, 1149-53.
- Li RF, Gupta M, McCluggage WG, et al (2013). Embryonal rhabdomyosarcoma (botryoid type) of the uterine corpus and cervix in adult women: report of a case series and review of the literature. Am J Surg Pathol, 37, 344-55. https://doi.org/10.1097/PAS.0b013e31826e0271
- McCann GA, Boutsicaris CE, Preston MM, et al (2013). Neuroendocrine carcinoma of the uterine cervix: the role of multimodality therapy in early-stage disease. Gynecol Oncol, 129, 135-9. https://doi.org/10.1016/j.ygyno.2013.01.014
- Ohta Y, Kunimura T, Omatsu M, et al (2013). Mixed mucinproducing and squamous differentiated tumor of the uterine cervix: a report of a case as adenosquamous carcinoma in situ. J Obstet Gynaecol Res, 39, 420-3. https://doi.org/10.1111/j.1447-0756.2012.01904.x
- Piura E, Piura B (2012). Brain metastases from cervical carcinoma: overview of pertinent literature. Eur J Gynaecol Oncol, 33, 567-73.
- Pruski D, Fraszczak J, Iwaniec K, et al (2012). Assessment of frequency of regression and progression of mild cervical neoplasia-LGSIL in women with positive high-risk HPV DNA test result. Ginekol Pol, 83, 572-5.
- Rai B, Patel FD, Chakraborty S, et al (2013). Bladder-rectum spacer balloon in high-dose-rate brachytherapy in cervix carcinoma. Int J Radiat Oncol Biol Phys, 85, e217-22. https://doi.org/10.1016/j.ijrobp.2012.09.037
- Salehi M, Taheri T, Mohit E, et al (2012). Recombinant Leishmania tarentolae encoding the HPV type 16 E7 gene in tumor mice model. Immunotherapy, 4, 1107-20. https://doi.org/10.2217/imt.12.110
- Singhal P, Hussain S, Thakur N, et al (2013). Association of MDM2 and p53 polymorphisms with the advancement of cervical carcinoma. DNA Cell Biol, 32, 19-27. https://doi.org/10.1089/dna.2012.1718
- Xue Y, An R, Zhang D, et al (2011). Detection of survivin expression in cervical cancer cells using molecular beacon imaging: new strategy for the diagnosis of cervical cancer. Eur J Obstet Gynecol Reprod Biol, 159, 204-8. https://doi.org/10.1016/j.ejogrb.2011.06.038
- Zeng XT, Xiong PA, Wang F, et al (2012). Passive smoking and cervical cancer risk: a meta-analysis based on 3,230 cases and 2,982 controls. Asian Pac J Cancer Prev, 13, 2687-93. https://doi.org/10.7314/APJCP.2012.13.6.2687
- Zhao FH, Tiggelaar SM, Hu SY, et al (2012). A multi-center survey of HPV knowledge and attitudes toward HPV vaccination among women, government officials, and medical personnel in China. Asian Pac J Cancer Prev, 13, 2369-78. https://doi.org/10.7314/APJCP.2012.13.5.2369
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