Association of ABO Blood Group and Risk of Lung Cancer in a Multicenter Study in Turkey

  • Urun, Yuksel (Department of Medical Oncology, Ankara University School of Medicine) ;
  • Utkan, Gungor (Department of Medical Oncology, Ankara University School of Medicine) ;
  • Cangir, Ayten Kayi (Department of Thoracic Surgery, Ankara University School of Medicine) ;
  • Oksuzoglu, Omur Berna (Department of Medical Oncology, Dicle University Faculty of Medicine) ;
  • Ozdemir, Nuriye (Department of Medical Oncology, Dicle University Faculty of Medicine) ;
  • Oztuna, Derya Gokmen (Department of Biostatistics, Ankara University School of Medicine) ;
  • Kocaman, Gokhan (Department of Thoracic Surgery, Ankara University School of Medicine) ;
  • Coskun, Hasan Senol (Department of Medical Oncology, Dicle University Faculty of Medicine) ;
  • Kaplan, Muhammet Ali (Department of Medical Oncology, Dicle University Faculty of Medicine) ;
  • Yuksel, Cabir (Department of Thoracic Surgery, Ankara University School of Medicine) ;
  • Demirkazik, Ahmet (Department of Medical Oncology, Ankara University School of Medicine) ;
  • Icli, Fikri (Department of Medical Oncology, Ankara University School of Medicine)
  • 발행 : 2013.05.30


Background: The ABO blood groups and Rh factor may affect the risk of lung cancer. Materials and Methods: We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them. Results: The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology. Conclusions: In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are necessary to define the mechanisms by which ABO blood type may influence the lung cancer risk.


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