- Volume 14 Issue 5
DOI QR Code
Association of ABO Blood Group and Risk of Lung Cancer in a Multicenter Study in Turkey
- Urun, Yuksel (Department of Medical Oncology, Ankara University School of Medicine) ;
- Utkan, Gungor (Department of Medical Oncology, Ankara University School of Medicine) ;
- Cangir, Ayten Kayi (Department of Thoracic Surgery, Ankara University School of Medicine) ;
- Oksuzoglu, Omur Berna (Department of Medical Oncology, Dicle University Faculty of Medicine) ;
- Ozdemir, Nuriye (Department of Medical Oncology, Dicle University Faculty of Medicine) ;
- Oztuna, Derya Gokmen (Department of Biostatistics, Ankara University School of Medicine) ;
- Kocaman, Gokhan (Department of Thoracic Surgery, Ankara University School of Medicine) ;
- Coskun, Hasan Senol (Department of Medical Oncology, Dicle University Faculty of Medicine) ;
- Kaplan, Muhammet Ali (Department of Medical Oncology, Dicle University Faculty of Medicine) ;
- Yuksel, Cabir (Department of Thoracic Surgery, Ankara University School of Medicine) ;
- Demirkazik, Ahmet (Department of Medical Oncology, Ankara University School of Medicine) ;
- Icli, Fikri (Department of Medical Oncology, Ankara University School of Medicine)
- Published : 2013.05.30
Background: The ABO blood groups and Rh factor may affect the risk of lung cancer. Materials and Methods: We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them. Results: The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology. Conclusions: In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are necessary to define the mechanisms by which ABO blood type may influence the lung cancer risk.
ABO blood;group system;lung neoplasms;cancer;risk factors
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