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Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

  • Ellidag, Hamit Yasar (Central Laboratories of Antalya Education and Research Hospital of Ministry of Health) ;
  • Eren, Esin (Antalya Public Health Center of Ministry of Health) ;
  • Aydin, Ozgur (Central Laboratories of Antalya Education and Research Hospital of Ministry of Health) ;
  • Akgol, Evren (Izmir Ataturk Education and Training Hospital, Biochemistry Department) ;
  • Yalcinkaya, Soner (Urology Clinic of Antalya Education and Research Hospital of Ministry of Health) ;
  • Sezer, Cem (Pathology laboratories of Antalya Education and Research Hospital of Ministry of Health) ;
  • Yilmaz, Necat (Central Laboratories of Antalya Education and Research Hospital of Ministry of Health)
  • Published : 2013.05.30

Abstract

Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, $67.4{\pm}12$ years) and forty age-sex matched healthy persons (mean age $56.0{\pm}1.7$ years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj- IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

Keywords

Bladder cancer;ischemia modified albumin;oxidative stress;total antioxidant status;total oxidant status

References

  1. Badjatia N, Satyam A, Singh P, Seth A, Sharma A (2010). Altered antioxidant status and lipid peroxidation in Indian patients with urothelial bladder carcinoma. Urol Oncol, 28, 360-7. https://doi.org/10.1016/j.urolonc.2008.12.010
  2. Ballmer PE, Ochsenbein AF, Schutz-Hofmann S (1994). Transcapillary escape rate of albumin positively correlates with plasma albumin concentration in acute but not in chronic inflammatory disease. Metabolism, 43, 697-705. https://doi.org/10.1016/0026-0495(94)90117-1
  3. Bar-Or D, Lau E, Winkler JV (2000). A novel assay for cobaltalbumin binding and its potential as a marker for myocardial ischemia?A Preliminary Report. Emerg Med J, 19, 311-5. https://doi.org/10.1016/S0736-4679(00)00255-9
  4. Can M, Demirtas S, Polat O, Yildiz A (2006). Evaluation of effects of ischaemia on the albumin cobalt binding (ACB) assay in patients exposed to trauma. Emerg Med J, 23, 537. https://doi.org/10.1136/emj.2005.030486
  5. Christenson RH, Duh SH, Sanhai WR (2001). Characteristics of an albumin cobalt binding test for assessment of acute coronary syndrome patients: a multicenter study. Clinical Chemistry, 47, 464-70.
  6. Crawford A, Fassett RG, Geraghty DP, et al (2012). Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease. Gene, 501, 89-103. https://doi.org/10.1016/j.gene.2012.04.011
  7. Di Fiore F, Lecleire S, Pop D, et al (2007). Baseline nutritional status is predictive of response to treatment and survival in patients treated by definitive chemoradiotherapy for a locally advanced esophageal cancer. Am J Gastroenterol, 102, 2557-63. https://doi.org/10.1111/j.1572-0241.2007.01437.x
  8. Erel O (2004). A novel automated direct measurement method for total antioxidant capacity using a new generationmore stable ABTS radical cation. Clin Biochem, 37, 277-85. https://doi.org/10.1016/j.clinbiochem.2003.11.015
  9. Erel O (2005). A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38, 1103-11. https://doi.org/10.1016/j.clinbiochem.2005.08.008
  10. Ferlay J, Shin H, Bray F, Mathers C, Parkin DM (2008). GLOBOCAN, (IARC) Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Lyon, France: IARC Press, 2010.
  11. Fidan E, Mentese A, Kavgaci H, et al (2012). Increased ischemiamodified albumin levels in patients with gastric cancer. Neoplasma, 59, 393-7 https://doi.org/10.4149/neo_2012_051
  12. Gecit I, Aslan M, Gunes M, et al (2012). Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer. J Cancer Res Clin Oncol, 138, 739-43. https://doi.org/10.1007/s00432-011-1136-4
  13. Harma M, Harma M, Erel O (2003). Increased oxidative stress in patients with hydatidiform mole. Swiss MedWkly, 133, 563-66.
  14. Ishizuka M, Nagata H, Takagi K, Horie T, Kubota K (2007). Inflammation-based prognostic score is a novel predictor of postoperative outcome in patients with colorectal cancer. Ann Surg, 246, 1047-51. https://doi.org/10.1097/SLA.0b013e3181454171
  15. Kotur-Stevuljevic J, Memon L, Stefanovic A, et al (2007). Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients. Clin Biochem, 40, 181-7. https://doi.org/10.1016/j.clinbiochem.2006.09.007
  16. Lippi G, Montagnana M (2009). Ischemia-modified albumin in ischemic disorders. Ann Thorac Cardiovasc Surg, 15, 137.
  17. Lippi G, Montagnana M, Salvagno GL, Guidi GC (2007). Standardization of ischaemia modified albumin testing: adjustment for serum albumin. Clin Chem Lab Med, 45, 261-2.
  18. Mantovani A, Allavena P, Sica A, Balkwill F (2008). Cancerrelated inflammation. Nature, 454, 436-44. https://doi.org/10.1038/nature07205
  19. Mastella AK, Moresco RN, Bisognin da Silva D, et al (2009). Evaluation of ischemia-modified albumin in myocardial infarction and prostatic diseases. Biomed Pharmacother, 63, 762-6. https://doi.org/10.1016/j.biopha.2008.12.002
  20. Montagnana M, Lippi G, Volpe A, et al (2006). Evaluation of cardiac laboratory markers in patients with systemic sclerosis. Clin Biochem, 39, 913-7. https://doi.org/10.1016/j.clinbiochem.2006.03.016
  21. Piwowar A, Knapik-Kordecka M, Warwas M (2008). Ischemiamodified albumin level in type 2 diabetes mellitus - Preliminary report. Dis Markers, 24, 311-7. https://doi.org/10.1155/2008/784313
  22. Refaai MA, Wright RW, Parvin CA, et al (2006). Ischemia modified albumin increases after skeletal muscle ischemia during arthroscopic knee surgery. Clin Chim Acta, 366, 264-8. https://doi.org/10.1016/j.cca.2005.10.020
  23. Roy D, Quiles J, Sharma R, et al (2004). Ischemia modified albumin concentrations in patients with peripheral vascular disease and exercise-induced skeletal muscle ischemia. Clin Chem, 50, 1656-60. https://doi.org/10.1373/clinchem.2004.031690
  24. Roy D, Quilles J, Gaze DC, et al (2006). Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin. Heart, 92, 113-4. https://doi.org/10.1136/hrt.2004.049643
  25. Senes M, Kazan N, Coskun O, et al (2007). Oxidative and nitrosative stress in acute ischaemic stroke. Ann Clin Biochem, 44, 43-7.
  26. Sinha MK, Roy D, Gaze DC, Collinson PO, Kaski JC (2004). Role of "ischemia modified albumin", a new biochemical marker of myocardial ischaemia, in the early diagnosis of acute coronary syndromes. Emerg Med J, 21, 29-34. https://doi.org/10.1136/emj.2003.006007
  27. Stachowicz-Stencel T, Synakiewicz A, Owczarzak A, Sliwi?ska A (2011). Ischemia-Modified Albumin as a biochemical marker in children with neuroblastoma and soft tissue sarcomas. Clin Lab Anal, 25, 255-8 https://doi.org/10.1002/jcla.20469
  28. Van der Zee PM, Verberne HJ, van Straalen JP, et al (2005). Ischemia-modified albumin measurements in symptom limited exercise myocardial perfusion scintigraphy reflect serum albumin concentrations but not myocardial ischemia. Clin Chem, 51, 1744-6. https://doi.org/10.1373/clinchem.2005.054635
  29. Van Rijn BB, Franx A, Sikkema JM, et al (2008). Ischemia modified albumin in normal pregnancy and preeclampsia. Hypertens Pregnancy, 27, 159-67. https://doi.org/10.1080/10641950701885147
  30. Vassalle C, Pratali L, Boni C, Mercuri A, Ndreu R (2008). An oxidative stress score as a combined measure of the pro-oxidant and antioxidant counterparts in patients with coronary artery disease. Clin Biochem, 41, 1162-7. https://doi.org/10.1016/j.clinbiochem.2008.07.005
  31. Von Meyenfeldt M (2005). Cancer-associated malnutrition: an introduction. Eur J Oncol Nurs, 9, 35-8. https://doi.org/10.1016/j.ejon.2005.09.001
  32. Yeun JY, Kaysen GA (1998). Factors influencing serum albumin in dialysis patients. Am J Kidney Dis, 32, 118-25.
  33. Zapico-Muniz E, Santalo-Bel M, Merce-Muntanola J, et al (2004). Ischemia-modified albumin during skeletal muscle ischemia. Clin Chem, 50, 1063-5. https://doi.org/10.1373/clinchem.2003.027789

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