- Volume 14 Issue 5
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Comprehensive Mutation Analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 Genes is Suggestive of a Non- Neoplastic Nature of Phenytoin Induced Gingival Overgrowth
- Swamikannu, Bhuminathan (Department of Prosthodontia, Sree Balaji Dental College and Hospital, Bharath University) ;
- Kumar, Kishore S. (Department of Orthodontia, Sree Balaji Dental College and Hospital, Bharath University) ;
- Jayesh, Raghavendra S. (Department of Prosthodontia, Sree Balaji Dental College and Hospital, Bharath University) ;
- Rajendran, Senthilnathan (Department of Oral and Maxillofacial Surgery, Meenakshiammal Dental College and Hospital) ;
- Muthupalani, Rajendran Shanmugam (Department of General Medicine, Sree Balaji Dental College and Hospital, Bharath University) ;
- Ramanathan, Arvind (Human Genetics Laboratory, Sree Balaji Dental College and Hospital, Bharath University)
- Published : 2013.05.30
Background: Dilantin sodium (phenytoin) is an antiepileptic drug, which is routinely used to control generalized tonic clonic seizure and partial seizure episodes. A few case reports of oral squamous cell carcinomas arising from regions of phenytoin induced gingival overgrowth (GO), and overexpression of mitogenic factors and p53 have presented this condition as a pathology with potential to transform into malignancy. We recently investigated the genetic status of p53 and H-ras, which are known to be frequently mutated in Indian oral carcinomas in GO tissues and found them to only contain wild type sequences, which suggested a non-neoplastic nature of phenytoin induced GO. However, besides p53 and H-ras, other oncogenes and tumor suppressors such as PIK3CA, p14ARF, p16INK4a and
Cancer from gingival overgrowth;phenytoin induced gingival carcinoma;drug induced gingival carcinoma
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- mutations in South Indian oral cancers vol.23, pp.5, 2017, https://doi.org/10.1111/odi.12655