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Oncogenesis and the Clinical Significance of K-ras in Pancreatic Adenocarcinoma

  • Huang, Chun (Department of General Surgery, Three Gorges Medical College) ;
  • Wang, Wei-Min (Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University) ;
  • Gong, Jian-Ping (Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University) ;
  • Yang, Kang (Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University)
  • Published : 2013.05.30

Abstract

The RAS family genes encode small GTP-binding cytoplasmic proteins. Activated KRAS engages multiple effector pathways, notably the RAF-mitogen-activated protein kinase, phosphoinositide-3-kinase (PI3K) and RalGDS pathways. In the clinical field, K-ras oncogene activation is frequently found in human cancers and thus may serve as a potential diagnostic marker for cancer cells in circulation. This mini-review aims to summarise information on Ras-induced oncogenesis and the clinical significance of K-ras.

Keywords

k-ras gene;pancreatic carcinoma;PI3K-kinase-AKT;carcinogensis;oncogene;clinical meaning

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  1. Co-amplification at Lower Denaturation-temperature PCR Combined with Unlabled-probe High-resolution Melting to Detect KRAS Codon 12 and 13 Mutations in Plasma-circulating DNA of Pancreatic Adenocarcinoma Cases vol.15, pp.24, 2015, https://doi.org/10.7314/APJCP.2014.15.24.10647