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Histopathology Analysis of Benign Colorectal Diseases and Colorectal Cancer in Hatyai Hospital, Songkhla, Thailand

  • Kotepui, Manas (Medical Technology Program, School of Allied Health Sciences and Public Health, Walailak University) ;
  • Piwkham, Duangjai (Medical Technology Program, School of Allied Health Sciences and Public Health, Walailak University) ;
  • Songsri, Apiram (Department of Pathology, Hatyai Hospital) ;
  • Charoenkijkajorn, Lek (Department of Pathology, Hatyai Hospital)
  • Published : 2013.04.30

Abstract

Background: Colorectal cancer (CRC) is a major cause of morbidity and mortality in the western world and also ranks as the fifth-leading malignancy and death in Thailand. This study aimed to provide a present outlook of colorectal diseases among Thai patients with special emphasis on CRC in Hatyai, Songkhla, southern Thailand. Materials and Methods: This retrospective study covered ten year data of CRC, benign colorectal tumors and non-colorectal tumors from the Department of Pathology in Hatyai Hospital, Songkhla, Thailand, between years 2003-2012. Incidence rates based on age, gender, ten year incidence trends, and distribution of histopathological characteristics of patients were calculated and demonstrated. Results: Out of 730 biopsies, 100 cases were benign colorectal tumors, 336 were CRC and 294 were non-colorectal tumors. Colorectal tumors (both benign and CRC) (60.1%) were more common than non-colorectal tumors (39.9%). CRC (77.1%) were more common than benign colorectal tumors (32.9%). Colorectal tumors were mainly found in patients aged over sixty whereas non-colorectal and benign colorectal tumors were found in those under sixty (P=0.01). sAmong CRC, adenocarcinoma contributed about 97.3% of all cases with well differentiated tumors being the most frequent (56.9%). Both benign colorectal tumors and CRC were more commonly found in males (63%) than females (37%). The incidence trend of CRC demonstrated increase from 2003-2012. Conclusions: The incidence of CRC increased in Hatyai from 2003-2012. CRC tends to be more common in people older than sixty, thus, screening programs, cost-effective analysis of treatment modalities, and treatment protocols for the elderly should be examined. Proper implementation of preventive measures such as changing lifestyle factors might enhance control of colorectal disease.

References

  1. Ahsan H, Neugut AI, Garbowski GC, et al (1998). Family history of colorectal adenomatous polyps and increased risk for colorectal cancer. Ann Intern Med, 128, 900-5. https://doi.org/10.7326/0003-4819-128-11-199806010-00006
  2. Atreya R, Neurath MF (2005). Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. Clin Rev Allergy Immunol, 28, 187-96. https://doi.org/10.1385/CRIAI:28:3:187
  3. Bernstein CN, Blanchard JF, Kliewer E, Wajda A (2001). Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer, 91, 854-62. https://doi.org/10.1002/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z
  4. Bussey HJR (1975). Familial polyposis coli: family studies, histopathology, differential diagnosis and results of treatment. Baltimore: Johns Hopkins University Press.
  5. Cappell MS, Forde KA (1989). Spatial clustering of multiple hyperplastic, adenomatous, and malignant colonic polyps in individual patients. Dis Colon Rectum, 32, 641-52. https://doi.org/10.1007/BF02555767
  6. Chan DS, Lau R, Aune D, et al (2011). Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PLoS One, 6, 20456. https://doi.org/10.1371/journal.pone.0020456
  7. Chindaprasirt J, Sookprasert A, Wirasorn K, et al (2012). Cost of colorectal cancer care in hospitalized patients of Thailand. J Med Assoc Thai, 95, 196-200.
  8. Chong VH, Abdullah MS, Telisinghe PU, Jalihal A (2009). Colorectal cancer: incidence and trend in Brunei Darussalam. Singapore Med J, 50, 1085-9.
  9. Eaden JA, Abrams KR, Mayberry JF (2001). The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut, 48, 526-35. https://doi.org/10.1136/gut.48.4.526
  10. Ekbom A, Helmick C, Zack M, Adami HO (1990). Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med, 323, 1228-33. https://doi.org/10.1056/NEJM199011013231802
  11. Fantini MC, Pallone F (2008). Cytokines: from gut inflammation to colorectal cancer. Curr Drug Targets, 9, 375-80. https://doi.org/10.2174/138945008784221206
  12. Feik E, Baierl A, Hieger B, et al (2010). Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk. Cancer Causes Control, 21, 91-7. https://doi.org/10.1007/s10552-009-9438-4
  13. Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
  14. Friedenreich C, Norat T, Steindorf K, et al (2006). Physical activity and risk of colon and rectal cancers: the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev, 15, 2398-407. https://doi.org/10.1158/1055-9965.EPI-06-0595
  15. Ghabeljoo M, Jafarabadi MA, Mohammadi SM, et al (2011). Patterns of survival for anatomical sites of colorectal cancer with shift to advanced lesions in Iran. Asian Pac J Cancer Prev, 12, 1225-31.
  16. Giovannucci E (2002). Modifiable risk factors for colon cancer. Gastroenterol Clin North Am, 31, 925-43.
  17. Grivennikov SI (2013). Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol, 35, 229-44. https://doi.org/10.1007/s00281-012-0352-6
  18. Hav M, Eav S, Ky V, et al (2011). Colorectal cancer in young Cambodians. Asian Pac J Cancer Prev, 12, 1001-5.
  19. Hiraoka S, Kato J, Fujiki S, et al (2010). The presence of large serrated polyps increases risk for colorectal cancer. Gastroenterology, 139, 1503-10, https://doi.org/10.1053/j.gastro.2010.07.011
  20. Ji BT, Devesa SS, Chow WH, Jin F, Gao YT (1998). Colorectal cancer incidence trends by subsite in urban Shanghai, 1972-1994. Cancer Epidemiol Biomarkers Prev, 7, 661-6.
  21. Kanemitsu Y, Kato T, Hirai T, et al (2003). Survival after curative resection for mucinous adenocarcinoma of the colorectum. Dis Colon Rectum, 46, 160-7. https://doi.org/10.1007/s10350-004-6518-0
  22. Khuhaprema T, Srivatanakul P (2008). Colon and rectum cancer in Thailand: an overview. Jpn J Clin Oncol, 38, 237-43. https://doi.org/10.1093/jjco/hyn020
  23. Larsson SC, Wolk A (2006). Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies. Int J Cancer, 119, 2657-64. https://doi.org/10.1002/ijc.22170
  24. Liang JJ, Bissett I, Kalady M, Bennet A, Church JM (2012). Importance of serrated polyps in colorectal carcinogenesis. ANZ J Surg, In press.
  25. Liu L, Lemmens VE, De Hingh IH, et al (2013). Second primary cancers in subsites of colon and rectum in patients with previous colorectal cancer. Dis Colon Rectum, 56, 158-68. https://doi.org/10.1097/DCR.0b013e318279eb30
  26. Lohsoonthorn P, Danvivat D (1995). Colorectal cancer risk factors: a case-control study in Bangkok. Asia Pac J Public Health, 8, 118-22. https://doi.org/10.1177/101053959500800211
  27. Longo R, Morabito A, Carillio G, et al (2006). Multiorganic dissemination of a colorectal signet ring cell carcinoma with fulminant clinical course. Int J Gastrointest Cancer, 37, 49-54. https://doi.org/10.1385/IJGC:37:1:49
  28. Nozoe T, Anai H, Nasu S, Sugimachi K (2000). Clinicopathological characteristics of mucinous carcinoma of the colon and rectum. J Surg Oncol, 75, 103-7. https://doi.org/10.1002/1096-9098(200010)75:2<103::AID-JSO6>3.0.CO;2-C
  29. O'Sullivan J, Risques RA, Mandelson MT, et al (2006). Telomere length in the colon declines with age: a relation to colorectal cancer? Cancer Epidemiol Biomarkers Prev, 15, 573-7. https://doi.org/10.1158/1055-9965.EPI-05-0542
  30. Risques RA, Lai LA, Brentnall TA, et al (2008). Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage. Gastroenterology, 135, 410-8. https://doi.org/10.1053/j.gastro.2008.04.008
  31. Roessner A, Kuester D, Malfertheiner P, Schneider-Stock R (2008). Oxidative stress in ulcerative colitis-associated carcinogenesis. Pathol Res Pract, 204, 511-24. https://doi.org/10.1016/j.prp.2008.04.011
  32. Sachar DB (1994). Cancer in Crohn's disease: dispelling the myths. Gut, 35, 1507-8. https://doi.org/10.1136/gut.35.11.1507
  33. Sanchez NF, Stierman B, Saab S, et al (2012). Physical activity reduces risk for colon polyps in a multiethnic colorectal cancer screening population. BMC Res Notes, 5, 312. https://doi.org/10.1186/1756-0500-5-312
  34. Slattery ML (2004). Physical activity and colorectal cancer. Sports Med, 34, 239-52. https://doi.org/10.2165/00007256-200434040-00004
  35. Sonnenberg A, Genta RM (2012). Helicobacter pylori is a risk factor for colonic neoplasms. Am J Gastroenterol, 108, 208-15.
  36. Sriamporn S, Wiangnon S, Suwanrungruang K, et al (2007). Risk factors for colorectal cancer in northeast Thailand: lifestyle related. Asian Pac J Cancer Prev, 8, 573-7.
  37. Sriplung H, Wiangnon S, Sontipong S, Sumitsawan Y, Martin N (2006). Cancer incidence trends in Thailand, 1989-2000. Asian Pac J Cancer Prev, 7, 239-44.
  38. Triantafillidis JK, Nasioulas G, Kosmidis PA (2009). Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res, 29, 2727-37.
  39. Tsai CJ, Lu DK (1995). Small colorectal polyps: histopathology and clinical significance. Am J Gastroenterol, 90, 988-94.
  40. Tsong WH, Koh WP, Yuan JM, et al (2007). Cigarettes and alcohol in relation to colorectal cancer: the Singapore Chinese Health Study. Br J Cancer, 96, 821-7. https://doi.org/10.1038/sj.bjc.6603623
  41. Vucenik I, Stains JP (2012). Obesity and cancer risk: evidence, mechanisms, and recommendations. Ann NY Acad Sci, 1271, 37-43. https://doi.org/10.1111/j.1749-6632.2012.06750.x
  42. Winther KV, Jess T, Langholz E, Munkholm P, Binder V (2004). Long-term risk of cancer in ulcerative colitis: a population-based cohort study from Copenhagen County. Clin Gastroenterol Hepatol, 2, 1088-95. https://doi.org/10.1016/S1542-3565(04)00543-9
  43. Wolin KY, Lee IM, Colditz GA, et al (2007). Leisure-time physical activity patterns and risk of colon cancer in women. Int J Cancer, 121, 2776-81. https://doi.org/10.1002/ijc.23009
  44. Zarchy TM, Ershoff D (1996). Risk of colorectal cancer in families of patients with adenomatous polyps. N Engl J Med, 334, 1339-40. https://doi.org/10.1056/NEJM199605163342016

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