- Volume 14 Issue 4
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Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Versus Placebo as Maintenance Therapy for Advanced Non-small-cell Lung Cancer: A Meta-analysis of Randomized Controlled Trials
- Alimujiang, S. (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
- Zhang, Tao (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
- Han, Zhi-Gang (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
- Yuan, Shuai-Fei (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
- Wang, Qiang (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
- Yu, Ting-Ting (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University) ;
- Shan, Li (Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University)
- Published : 2013.04.30
Background: Use of epidermal growth factor receptor inhibitors (EGFR-TKIs ) is now standard for non-small-cell lung cancer (NSCLC). However, the effects of EGFR-TKIs in maintenance therapy for advanced NSCLC patients are still unclear. The preent meta-analysis was performed to examine pooled data of randomized control trials (RCT) where EGFR-TKIs were compared against placebo in maintenance regimens for patients with advanced NCSLC to quantify potential benefits and determine safety. Methods: Several data bases were searched, including PubMed, EMBASE and CENTRAL, and we performed an internet search of conference literature. The endpoints were objective response rates (ORR), progression-free survival (PFS) and overall survival (OS). We performed a meta-analysis of the published data, using Comprehensive Meta Analysis software (Version 2.0). with a fixed effects model and an additional random effects model, when applicable. The results of the meta-analysis are expressed as hazard ratios (HRs) or risk ratios (RRs), with their corresponding 95% confidence intervals (95%CIs). Results: The final analysis included six trials, covering 3,758 patients. Compared with placebo, EGFR-TKIs maintenance therapy improved ORR and PFS for patients with advanced NSCLC, the difference being statistically significant (P<0.05), but proved unable to prolong patients' OS. The main adverse reactions were diarrhea and rashes. Conclusion: EGFR-TKIs demonstrated encouraging efficacy, safety and survival when delivered as maintenance therapy for patients with advanced NSCLC after first-line chemotherapy, especially for the patients who had adenocarcinomas, were female, non-smokers and patients with EGFR gene mutations.
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