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Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver

  • Gurocak, Simay (Department of Radiation Oncology, Inonu University School of Medicine) ;
  • Karabulut, Ercan (Department of Pharmacology, Cukurova University School of Medicine) ;
  • Karadag, Nese (Department of Patology, Inonu University School of Medicine) ;
  • Ozgor, Dincer (Department of General Surgery, Inonu University School of Medicine) ;
  • Ozkeles, Neslihan (Department of Radiation Oncology, Inonu University School of Medicine) ;
  • Karabulut, Aysun Bay (Department of Biochemistry, Inonu University School of Medicine)
  • Published : 2013.04.30

Abstract

Background: In recent years, due to modern lifestyles and exposure to chemical carcinogens, cancer cases are steadily increasing. From this standpoint, azoxymethane (AOM), a chemical carcinogen which causes de novo liver damage, and resveratrol, which is an antioxidant found in foods and protects against oxidative stress damage, are of interest. We here aimed to evaluate whether resveratrol could protect the liver tissues from the effects of AOM. Materials and Methods: The study was conducted in 4 groups, each consisting of seven rats, the first receiving only AOM (2 times per week, 5 mg/kg), group 2 AOM and resveratrol (2 times a week, 20 mg/kg), group 3 assessed only as a control and group 4 administered only resveratrol. At the end of the seventh week, the rats were sacrificed. Rat liver MDA, NO, GSH levels were analyzed biochemically, as well as the tissues being evaluated histopathologically. Results: MDA and NO increased in AOM group as signs of increased oxidative stress. The group concomitantly administered resveratrol was been found to be significantly decreased in MDA and NO levels and increased in GSH activity. However, there were no significant findings on histopathological evaluation. Conclusions: In the light of these results, resveratrol appears to exert protective effect on oxidative s tress in the liver tissue due to deleterious effects of chemical carcinogens.

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