- Volume 14 Issue 4
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Current Evidence on Associations Between the MMP-7 (-181A>G) Polymorphism and Digestive System Cancer Risk
- Ke, Pan (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University) ;
- Wu, Zhong-De (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University) ;
- Wen, Hua-Song (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University) ;
- Ying, Miao-Xiong (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University) ;
- Long, Huo-Cheng (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University) ;
- Qing, Liu-Guo (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University)
- Published : 2013.04.30
Matrix metalloproteinases (MMPs) degrade various components of the extracellular matrix and functional polymorphisms in encoding genes may contribute to genetic susceptibility to many cancers. Up to now, associations between MMP-7 (-181A>G) and digestive system cancer risk have remained inconclusive. To better understand the role of the MMP-7 (-181A>G) genotype in digestive cancer development, we conducted this comprehensive meta-analysis encompassing 3,518 cases and 4,596 controls. Overall, the MMP-7 (-181A>G) polymorphism was associated with higher digestive system cancer risk on homozygote comparison (GG vs. AA, OR=1.21, 95% CI = 1.12-1.60) and in a dominant model (GG/GA vs. AA, OR=1.16, 95% CI =1.03-1.46). On subgroup analysis, this polymorphism was significantly linked to higher risks for gastric cancer (GG vs. AA, OR=1.22, 95% CI = 1.02-1.46; GA vs. AA, OR=1.82, 95% CI =1.16-2.87; GG/GA vs. AA, OR=1.13, 95% CI =1.01-1.27; GG vs. GA/AA, OR= 1.25, 95% CI = 1.06-2.39. We also observed increased susceptibility to colorectal cancer and esophageal SCC in both homozygote (OR = 1.13, 95% CI = 1.06-1.26) and heterozygote comparisons (OR = 1.45, 95% CI = 1.11-1.91). In the stratified analysis by controls, significant effects were only observed in population-based studies (GA vs. AA, OR=1.16, 95% CI=1.08-1.50; GA/AA vs. GG, OR=1.10, 95% CI=1.01-1.72). According to the source of ethnicity, a significantly increased risk was found among Asian populations in the homozygote model (GG vs. AA, OR=1.40, 95% CI=1.12-1.69), heterozygote model (GA vs. AA, OR=1.26, 95% CI=1.02-1.51), and dominant model (GG/GA vs. AA, OR=1.18, 95% CI=1.08-1.55). Our findings suggest that the MMP-7 (-181A>G) polymorphism may be a risk factor for digestive system cancer, especially among Asian populations.
- Bo P, Lihuan C, Xiaopin M, et al (2010). Meta-analysis of association between matrix metalloproteinases 2, 7 and 9 promoter polymorphisms and cancer risk. Mutagenesis, 25, 371-9. https://doi.org/10.1093/mutage/geq015
- de Lima JM, de Souza LG, da Silva ID, et al (2009). E-cadherin and metalloproteinase-1 and-7 polymorphisms in colorectal cancer. Int J Biol Markers, 24, 99-106.
- Dziki L, Przybylowska K, Majsterek I, et al (2011). A/G Polymorphism of the MMP-7 Gene Promoter Region in Colorectal Cancer. Pol Przegl Chir, 83, 622-6.
- Fang W-L, Liang W-B, He H, et al (2010). Association of Matrix Metalloproteinases 1, 7, and 9 Gene Polymorphisms with Genetic Susceptibility to Colorectal Carcinoma in a Han Chinese Population. DNA Cell Biol, 29, 657-61. https://doi.org/10.1089/dna.2010.1017
- Ghilardi G, Biondi ML, Erario M, et al (2003). Colorectal carcinoma susceptibility and metastases are associated with matrix metalloproteinase-7 promoter polymorphisms. Clin Chem, 49, 1940-2. https://doi.org/10.1373/clinchem.2003.018911
- Greenwald RJ, Oosterwegel MA, van der Woude D, et al (2002). CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol, 32, 366-73. https://doi.org/10.1002/1521-4141(200202)32:2<366::AID-IMMU366>3.0.CO;2-5
- Hodi FS, Mihm MC, Soiffer RJ, et al (2003). Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci USA, 100, 4712-17. https://doi.org/10.1073/pnas.0830997100
- Jormsjo S, Whatling C, Walter DH, et al (2001). Allele specific regulation of matrix metalloproteinase-7 promoter activity is associated with coronary artery luminal dimensions among hypercholesterolemic patients. Arterioscler Thromb Vasc Biol, 21, 1834-39. https://doi.org/10.1161/hq1101.098229
- Kim JH, Pyun JA, Lee KJ, et al (2011). [Study on association between single nucleotide polymorphisms of MMP7, MMP8, MMP9 genes and development of gastric cancer and lymph node metastasis]. Korean J Gastroenterol, 58, 245-51. https://doi.org/10.4166/kjg.2011.58.5.245
- Kubben FJGM, Sier CFM, Meijer MJW, et al (2006). Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer. Br J Cancer, 95, 744-51. https://doi.org/10.1038/sj.bjc.6603307
- Li JY, Tian MM, Zhao AL (2008). Polymorphism in the promoter region of the metalloproteinase-7 increases susceptibility and risk of metastasis of gastric adenocarcinoma. Gastroenterology, 134, A603.
- Li Y, Jin X, Kang S, et al (2006). Polymorphisms in the promoter regions of the matrix metalloproteinases-1,-3,-7, and-9 and the risk of epithelial ovarian cancer in China. Gynecol Oncol, 101, 92-6. https://doi.org/10.1016/j.ygyno.2005.09.058
- Lievre A, Milet J, Carayol J, et al (2006). Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. BMC Cancer, 6, 270. https://doi.org/10.1186/1471-2407-6-270
- Malik MA, Sharma KL, Zargar SA, et al (2011). Association of matrix metalloproteinase-7 (-181A>G) polymorphism with risk of esophageal squamous cell carcinoma in Kashmir Valley. Saudi J Gastroenterol, 17, 301-6. https://doi.org/10.4103/1319-3767.84480
- Malik MA, Zargar SA, Mittal B (2011). Role of the metalloproteinase-7 (181A>G) polymorphism in gastric cancer susceptibility: a case control study in Kashmir valley. Asian Pac J Cancer Prev, 12, 73-6.
- Ohtani H, Maeda N, Murawaki Y (2009). Functional polymorphisms in the promoter regions of matrix metalloproteinase-2,-3,-7,-9 and TNF-alpha genes, and the risk of colorectal neoplasm in Japanese. Yonago Acta Medica, 52,47-56
- Qiu W, Zhou G, Zhai Y, et al (2008). No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population. Cancer Epidemiol Biomarkers Prev, 17, 2514-8. https://doi.org/10.1158/1055-9965.EPI-08-0557
- Singh H, Jain M, Mittal B (2008). MMP-7 (-181A>G) promoter polymorphisms and risk for cervical cancer. Gynecol Oncol, 110, 71-5. https://doi.org/10.1016/j.ygyno.2008.03.007
- Sugimoto M, Furuta T, Kodaira C, et al (2008). Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan. J Gastroenterol, 43,751-61. https://doi.org/10.1007/s00535-008-2221-6
- Vairaktaris E, Serefoglou Z, Yapijakis C, et al (2007). High gene expression of matrix metalloproteinase-7 is associated with early stages of oral cancer. Anticancer Res, 27, 2493-8.
- Woo M, Park K, Nam J, et al (2007). Clinical implications of matrix metalloproteinase-1,-3,-7,-9,-12, and plasminogen activator inhibitor-1 gene polymorphisms in colorectal cancer. J Gastroenterol Hepatol, 22, 1064-70. https://doi.org/10.1111/j.1440-1746.2006.04424.x
- Wu S, Lu S, Tao H, et al (2011). Correlation of polymorphism of IL-8 and MMP-7 with occurrence and lymph node metastasis of early stage cervical cancer. J Huazhong Univ Sci Technol, 31, 114-9. https://doi.org/10.1007/s11596-011-0161-5
- Zhang J (2005). The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma. Carcinogenesis, 26, 1748-53. https://doi.org/10.1093/carcin/bgi144
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