DOI QR코드

DOI QR Code

Complex Regulatory Network of MicroRNAs, Transcription Factors, Gene Alterations in Adrenocortical Cancer

  • Zhang, Bo (Computer Science & Technology Department, Jilin University) ;
  • Xu, Zhi-Wen (Computer Science & Technology Department, Jilin University) ;
  • Wang, Kun-Hao (Computer Science & Technology Department, Jilin University) ;
  • Lu, Tian-Cheng (Jilin Agricultural University School of Life Sciences) ;
  • Du, Ye (First Hospital Department of Mammary Surgery, Jilin University)
  • 발행 : 2013.04.30

초록

Several lines of evidence indicate that cancer is a multistep process. To survey the mechanisms involving gene alteration and miRNAs in adrenocortical cancer, we focused on transcriptional factors as a point of penetration to build a regulatory network. We derived three level networks: differentially expressed; related; and global. A topology network ws then set up for development of adrenocortical cancer. In this network, we found that some pathways with differentially expressed elements (genetic and miRNA) showed some self-adaption relations, such as EGFR. The differentially expressed elements partially uncovered mechanistic changes for adrenocortical cancer which should guide medical researchers to further achieve pertinent research.

과제정보

연구 과제 주관 기관 : National Natural Science Foundation of China

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피인용 문헌

  1. Regulatory Network Analysis of MicroRNAs and Genes in Neuroblastoma vol.15, pp.18, 2014, https://doi.org/10.7314/APJCP.2014.15.18.7645
  2. Regulatory Network of MicroRNAs, Host Genes, Target Genes and Transcription Factors in Human Esophageal Squamous Cell Carcinoma vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3677