Complex Regulatory Network of MicroRNAs, Transcription Factors, Gene Alterations in Adrenocortical Cancer

  • Zhang, Bo (Computer Science & Technology Department, Jilin University) ;
  • Xu, Zhi-Wen (Computer Science & Technology Department, Jilin University) ;
  • Wang, Kun-Hao (Computer Science & Technology Department, Jilin University) ;
  • Lu, Tian-Cheng (Jilin Agricultural University School of Life Sciences) ;
  • Du, Ye (First Hospital Department of Mammary Surgery, Jilin University)
  • Published : 2013.04.30


Several lines of evidence indicate that cancer is a multistep process. To survey the mechanisms involving gene alteration and miRNAs in adrenocortical cancer, we focused on transcriptional factors as a point of penetration to build a regulatory network. We derived three level networks: differentially expressed; related; and global. A topology network ws then set up for development of adrenocortical cancer. In this network, we found that some pathways with differentially expressed elements (genetic and miRNA) showed some self-adaption relations, such as EGFR. The differentially expressed elements partially uncovered mechanistic changes for adrenocortical cancer which should guide medical researchers to further achieve pertinent research.


Supported by : National Natural Science Foundation of China


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