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Complex Regulatory Network of MicroRNAs, Transcription Factors, Gene Alterations in Adrenocortical Cancer

  • Zhang, Bo ;
  • Xu, Zhi-Wen ;
  • Wang, Kun-Hao ;
  • Lu, Tian-Cheng ;
  • Du, Ye
  • Published : 2013.04.30

Abstract

Several lines of evidence indicate that cancer is a multistep process. To survey the mechanisms involving gene alteration and miRNAs in adrenocortical cancer, we focused on transcriptional factors as a point of penetration to build a regulatory network. We derived three level networks: differentially expressed; related; and global. A topology network ws then set up for development of adrenocortical cancer. In this network, we found that some pathways with differentially expressed elements (genetic and miRNA) showed some self-adaption relations, such as EGFR. The differentially expressed elements partially uncovered mechanistic changes for adrenocortical cancer which should guide medical researchers to further achieve pertinent research.

Keywords

Adrenocortical cancer;network;transcription factor;MicroRNA;target gene;host gene

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Cited by

  1. Regulatory Network Analysis of MicroRNAs and Genes in Neuroblastoma vol.15, pp.18, 2014, https://doi.org/10.7314/APJCP.2014.15.18.7645
  2. Regulatory Network of MicroRNAs, Host Genes, Target Genes and Transcription Factors in Human Esophageal Squamous Cell Carcinoma vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3677

Acknowledgement

Supported by : National Natural Science Foundation of China