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Anti-Cancer Mechanism and Possibility of Nano-Suspension Formulation for a Marine Algae Product Fucoxanthin

  • Muthuirulappan, Srinivasan ;
  • Francis, Steffi Pulikodan
  • Published : 2013.04.30

Abstract

Recently, use of natural products available from marine sources, and especially algae products, are receiving more attention. Scientific evidence for claimed nutraceutical and therapeutical effects of one such marine algae product, fucoxanthin, is discussed in this paper with a summary of the currently available literature regarding its antioxidant, anti-obesity and anticancer activities. It is safe for use in humans, but as it has poor solubility a nano-suspension mode of delivery may be adopted to improve efficacy of supplments. We conclude from ourliterature review that the marine algae product fucoxanthin has significant antioxidant, anti-obesity and anticancer activity with established mechanisms of action.

Keywords

Anti-cancer mechanism;antioxidant activity;anti-obesity;fucoxanthin;marine algae

References

  1. Ayyad SE, Ezmirly ST, Basaif SA (2011). Antioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp. Pharmacognosy Res, 3, 160-5. https://doi.org/10.4103/0974-8490.85000
  2. Beppu F, Niwano Y, Tsukui T (2009). Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice. J Toxicol Sci, 34, 501-10. https://doi.org/10.2131/jts.34.501
  3. Heo SJ, Jeon YJ (2009). Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage. J Photochem Photobiol B, 95, 101-7. https://doi.org/10.1016/j.jphotobiol.2008.11.011
  4. Hu X, Li Y, Li C (2011). Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats. Arch Biochem Biophys, 519, 59-65.
  5. Ishikawa C, Tafuku S, Kadekaru T (2008). Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol. Int J Cancer, 123, 2702-12. https://doi.org/10.1002/ijc.23860
  6. Kelman D, Posner EK, McDermid KJ, et al (2012). Antioxidant activity of hawaiian marine algae. Mar Drugs, 10, 403-16. https://doi.org/10.3390/md10020403
  7. Kim KN, Heo SJ, Kang SM (2010). Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROSmediated Bcl-xL pathway. Toxicol In Vitro, 24, 1648-54. https://doi.org/10.1016/j.tiv.2010.05.023
  8. Kim SK, Pangestuti R (2011). Biological activities and potential health benefits of fucoxanthin derived from marine brown algae. Adv Food Nutr Res, 64, 111-28. https://doi.org/10.1016/B978-0-12-387669-0.00009-0
  9. Kotake-Nara E, Asai A, Nagao A (2005). Neoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells. Cancer Lett, 220, 75-84. https://doi.org/10.1016/j.canlet.2004.07.048
  10. Kotake-Nara E, Kushiro M, Zhang H (2001). Carotenoids affect proliferation of human prostate cancer cells. J Nutr, 131, 3303-6.
  11. Lai CS, Tsai ML, Badmaev V, (2012). Xanthigen Suppresses Preadipocyte Differentiation and Adipogenesis through Down-regulation of PPARgamma and C/EBPs and Modulation of SIRT-1, AMPK, and FoxO Pathways. J Agric Food Chem, 60, 1094-101. https://doi.org/10.1021/jf204862d
  12. Liu CL, Huang YS, Hosokawa M (2009). Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication. Chem Biol Interact, 182, 165-72. https://doi.org/10.1016/j.cbi.2009.08.017
  13. Miyashita K (2009). Function of marine carotenoids. Forum Nutr, 61, 136-46. https://doi.org/10.1159/000212746
  14. Miyashita K, Nishikawa S, Beppu F (2011). The allenic carotenoid fucoxanthin, a novel marine nutraceutical from brown seaweeds. J Sci Food Agric, 91, 1166-74. https://doi.org/10.1002/jsfa.4353
  15. Okada T, Mizuno Y, Sibayama S (2011). Antiobesity effects of Undaria lipid capsules prepared with scallop phospholipids. J Food Sci, 76, 2-6.
  16. Peng J, Yuan JP, Wu CF, et al (2011). Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health. Mar Drugs, 9, 1806-28. https://doi.org/10.3390/md9101806
  17. Riccioni G (2012). Marine carotenoids and oxidative stress. Mar Drugs, 10, 116-8. https://doi.org/10.3390/md10010116
  18. Sachindra NM, Sato E, Maeda H (2007). Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites. J Agric Food Chem, 55, 8516-22. https://doi.org/10.1021/jf071848a
  19. Sangeetha RK, Bhaskar N, Baskaran V (2009). Comparative effects of beta-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats. Mol Cell Biochem, 331, 59-67. https://doi.org/10.1007/s11010-009-0145-y
  20. Satomi Y, Nishino H (2009). Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells. Biochim Biophys Acta, 1790, 260-6. https://doi.org/10.1016/j.bbagen.2009.01.003
  21. Satomi Y (2012). Fucoxanthin Induces GADD45A Expression and G1 Arrest with SAPK/JNK Activation in LNCap Human Prostate Cancer Cells. Anticancer Res, 32, 807-13.
  22. Shimoda H, Tanaka J, Shan SJ (2010). Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules. J Pharm Pharmacol, 62, 1137-45. https://doi.org/10.1111/j.2042-7158.2010.01139.x
  23. Tanaka T, Shnimizu M, Moriwaki H (2012). Cancer chemoprevention by carotenoids. Molecules, 17, 3202-42. https://doi.org/10.3390/molecules17033202
  24. Urikura I, Sugawara T, Hirata T (2011). Protective effect of Fucoxanthin against UVB-induced skin photoaging in hairless mice. Biosci Biotechnol Biochem, 75, 757-60. https://doi.org/10.1271/bbb.110040
  25. Yamamoto K, Ishikawa C, Katano H (2011). Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas. Cancer Lett, 300, 225-34. https://doi.org/10.1016/j.canlet.2010.10.016
  26. Yim MJ, Hosokawa M, Mizushina Y (2011). Suppressive effects of Amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPARgamma and C/EBPalpha mRNA expression. J Agric Food Chem, 59, 1646-52. https://doi.org/10.1021/jf103290f
  27. Yonekura L, Kobayashi M, Terasaki M, et al (2010).Ketocarotenoids are the major metabolites of dietary lutein and fucoxanthin in mouse tissues. J Nutr, 140, 1824-31. https://doi.org/10.3945/jn.110.126466
  28. Yu RX, Hu XM, Xu SQ (2011). Effects of fucoxanthin on proliferation and apoptosis in human gastric adenocarcinoma MGC-803 cells via JAK/STAT signal pathway. Eur J Pharmacol, 657, 10-9. https://doi.org/10.1016/j.ejphar.2010.12.006
  29. Zaragoza MC, Lopez D, Saiz P (2008). Toxicity and antioxidant activity in vitro and in vivo of two Fucus vesiculosus extracts. J Agric Food Chem, 56, 7773-80. https://doi.org/10.1021/jf8007053
  30. Zhang Z, Zhang P, Hamada M (2008). Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line. Oncol Rep, 20, 1099-103.

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