Optimization of Synthesis Condition of Monolithic Sorbent Using Response Surface Methodology

반응 표면 분석법을 이용한 일체형 흡착제의 합성 조건 최적화

  • Park, Ha Eun (Department of Chemical Engineering, Inha University) ;
  • Row, Kyung Ho (Department of Chemical Engineering, Inha University)
  • 박하은 (인하대학교 화학공학과) ;
  • 노경호 (인하대학교 화학공학과)
  • Published : 2013.06.10


A 17-run Box-Behnken design was used to optimize the synthesis conditions of a monolithic sorbent. The effects of the amount of monomer (mL), crosslink (mL) and porogen (mL) were investigated. The experimental data were fitted to a second-order polynomial equation by the multiple regression analysis and examined using statistical methods. The adjusted coefficient of determination ($R^2$) of the model was 0.9915. The probability value (p < 0.0001) demonstrated a high significance for the regression model. A mean amount of polymer as 2120.15 mg was produced under the following optimum synthesis conditions: the optimized volumes of monomer, crosslink and porogen are 0.30, 1.40, and 1.47 mL, respectively. This was in good agreement with the predicted model value.


Box-Behnken design;monolithic sorbent;synthesis;response surface methodology


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