A Study on Nano-emulsion for Enhanced Transdermal Delivery of Hippophae rhamnoides Leaf Extract

비타민나무 잎 추출물의 피부 흡수 증진을 위한 나노에멀젼 연구

  • Chae, Kyo Young (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Kwon, Soon Sik (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Park, Soo Nam (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
  • 채교영 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실 화장품종합기술연구소) ;
  • 권순식 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실 화장품종합기술연구소) ;
  • 박수남 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실 화장품종합기술연구소)
  • Published : 2013.06.10

Abstract

In this study, nano-emulsions containing 0.01, 0.03, 0.05, and 0.10% ethyl acetate fraction of Hippophae rhamnoides (H. rhamnoides) leaf extracts were prepared. The particle size, particle size distribution and skin permeability of the nano-emulsions were evaluated for five weeks. Nano-emulsion was prepared by the sequential use of homogenizer and microfluidizer. Nano-emulsion containing the ethyl acetate fraction exhibited a monodispersed form. Nano-emulsion containing 0.03% ethyl acetate fraction was the most stable for five weeks. The in vitro skin permeation study of nano-emulsion containing 0.03% ethyl acetate fraction was carried out using Franz diffusion cell. The nano-emulsion showed a better skin permeability than that of O/W emulsion. These results indicate that the nano-emulsion containing the ethyl acetate fraction of H. rhamnoides leaf extract showed a remarkable stability and skin permeability than that of O/W emulsion.

Keywords

Hippophae rhamnoides leaf;nano-emulsion;transdermal delivery;Franz diffusion cell

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