Field Effect Transistors for Biomedical Application

전계효과트랜지스터의 생명공학 응용

  • Sohn, Young-Soo (Department of Biomedical Engineering, Catholic University of Daegu)
  • 손영수 (대구가톨릭대학교 의공학과)
  • Published : 2013.02.10


As the medical paradigm is changing from disease treatment to disease prevention and an early diagonosis, the demand to develop techniques for the detection of minute concentrations of biomolecules is increasing. Among the various techniques to sense the minute concentration of biomolecules, the biosensors utilizing the matured semiconductor techniques are presented here. To understand such biosensors, the structure and working principle of a MOSFET (Metal-oxide-semiconductor field-effect transistor) which is the basic semiconductor device is firstly introduced, and then the ISFET (Ion sensitive FET), BioFET (Biologically modified FET), Nanowire FET, and IFET (Ionic FET) are introduced, and their applications to biomedical fields are discussed.




  1. A. Kim, C. S. Ah, H. Y. Yu, J.-H. Yang, I. B. Baek, C.-G. Ahn, C. W. park, M. S. Jun, and S. Lee, Appl. Phys. Lett., 91, 103901 (2007).
  2. W. U. Wang, C. Chen, K.-H. Lin, Y. Fang, and C. M. Lieber, Proc. Natl. Acad. Sci., 102, 3208 (2005).
  3. E. Stern, J. K. Klemic, D. A. Routenberg, P. N. Wyrembak, D. B. Turner-Evans, A. D. Hamilton, D. A. LaVan, T. M. Fahmy, and M. A. Reed, Nature Lett., 445, 519 (2007).
  4. E. Stern, R. Wagner, F. J. Sigworth, R. Breaker, T. M. Fahmy, and M. A. Reed, Nano Lett., 7, 3405 (2007).
  5. P. K. Gupta, Trends Biotechnol., 26, 602 (2008).
  6. T. Kim and J. J. Pak, J. Sens. Sci. Technol., 21, 359 (2012).
  7. B. M. Venkatesan and R. Bashir, Nature Nanotech., 6, 615 (2011).
  8. M. Tsutsui, M. Taniguchi, K. Yokota, and T. Kawai, Nature Nanotech., 5, 286 (2010).
  9. X. Liang and S. Y. Chou, Nano Lett., 8, 1472 (2008).
  10. H. W. Ch Postma, Nano Lett., 10, 420 (2010).
  11. A. Singer, M. Wanunu, W. Morrison, H. Kuhn, M. Frank-Kamenetskii, and A. Meller, Nano Lett., 10, 738 (2010).
  12. A. J. Storm, J. H. Chen, X. S. Ling, H. W. Zandbergen, and C. Dekker, Nat. Mater., 2, 537 (2003).
  13. B. M. Venkatesan, A. B. Shah, J. M. Zuo, and R. Bashir, Adv. Funct. Mater., 20, 1266 (2010).
  14. H. Liu, J. He, J. Tang, P. Pang, D. Cao, P. Krstic, S. Joseph, S. Lindsay, and C. Nuckolls, Science, 327, 64 (2010).
  15. R. Fan, R. Karnik, M. Yue, D. Li, A. Majumdar, and P. Yang, Nano Lett., 5, 1633 (2005).
  16. S.-W. Nam, M. J. Rooks, K.-B. Kim, and S. M. Rossnagel, Nano Lett., 9, 2044 (2009).
  17. B. G. Streetman and S. K. Banerjee, Solid State Electronic Devices, 6 th Ed., 239, Pearson Prentice Hall, New Jersey (2006).
  18. P. Bergveld, IEEE Trans. Biomed. Eng., BME-17, 70 (1970).
  19. P. Bergveld, Sens. Actuators B, 88, 1 (2003).
  21. L. Bousse and P. Bergveld, Sens. Actuators B, 6, 65 (1984).
  22. A. van den Berg, P. Bergveld, D. N. Reinhoudt, and E. J. R. Sudholter, Sens. Actuators B, 8, 129 (1985).
  23. B.-K. Sohn et. al., Sensor Engineering, 195, Iljinsa, Seoul, Korea (2012).
  24. M.-N. Niu, X.-F. Ding, and Q.-Y. Tong, Sens. Actuators B, 37, 13 (1996).
  25. J.-C. Chou and C.-Y. Weng, Mater. Chem. Phys., 71, 120 (2001).
  26. D.-H. Kwon, B.-W. Cho, C.-S. Kim, and B.-K. Sohn, Sens. Actuators B, 34, 441 (1996).
  27. A. Morgenshtein, L. Sudakov-Boreysha, U. Dinnar, C. G. Jakobson, and Y. Nemirovsky, Sens. Actuators B, 98, 18 (2004).
  28. B.-K. Sohn, B.-W. Cho, C.-S. Kim, and D.-H. Kwon, Sens. Actuators B, 41, 7 (1997).
  29. W.-Y. Chunga, C.-H. Yang, D. G. Pijanowskac, P. B. Grabiec, and W. Torbicz, Sens. Actuators B, 113, 555 (2006).
  30. M. J. Schoning and A. Poghossian, Analyst, 127, 1137 (2002).
  31. K.-Y. Park, Y.-S. Sohn, C.-K. Kim, H.-S. Kim, Y.-S. Bae, and S.-Y. Choi, Biosens. Bioelectron., 23, 1904 (2008).
  32. Y.-S. Sohn, S.-K. Lee, and S.-Y. Choi, Sensor Lett., 5, 421 (2007).
  33. Y.-S. Sohn, C.-K. Kim, and S.-Y. Choi, Sensor Lett., 7, 640 (2009).
  34. D.-S. Kim, Y.-T. Jeong, H.-J. Park, J.-K. Shin, P. Choi, J.-H. Lee, and G. Lim, Biosens. Bioelectron., 20, 69 (2004).
  35. L. Wang, P. Estrela, E. Huq, P. Li, S. Thomas, P. K. Ferrigno, D. Paul, P. Adkin, and P. Migliorato, Microelectron. Eng., 47, 235 (1998).
  36. Y. Ishige, M. Shimoda, and M. Kamahori, Biosens. Bioelectron., 24, 1096 (2009).
  37. D.-S. Kim, J.-E. Park, J.-K. Shin, P. K. Kim, G. Lim, and S. Shoji, Sens. Actuators B, 117, 488 (2006).
  38. Y. Cui, Q. Wei, H. Park, and C. M. Lieber, Science, 293, 1289 (2001).
  39. M. Curreli, R. Zhang, F. N. Ishikawa, H.-K. Chang, R. J. Cote, C. Zhou, and M. E. Thompson, IEEE Trans. Nanotechnol., 7, 651 (2008).
  40. Z. Gao, A. Agarwal, A. D. Trigg, N. Singh, C. Fang, C.-H. Tung, Y. Fan, K. D. Buddharaju, and J. Kong, Anal. Chem., 79, 3291 (2007).
  41. F. Patolsky, B. T. Timko, G. Zheng, and C. M. Lieber, MRS Bull., 32, 142 (2007).