Memory Enhancing Effect of Codonopsis lanceolata by High Hydrostatic Pressure Process and Fermentation

초고압 발효 더덕 추출물의 인지능력 개선 효과

  • Weon, Jin Bae (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Lee, Bohyoung (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Yun, Bo-Ra (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Lee, Jiwoo (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Lee, Hyeon Yong (Department of Teaics, Seowon University) ;
  • Park, Dong-Sik (Functional food & Nutrition Division, Department of Agrofood Resources) ;
  • Chung, Hee-Chul (Newtree CO., LTD.) ;
  • Chung, Jae Youn (Newtree CO., LTD.) ;
  • Ma, Choong Je (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
  • 원진배 (강원대학교 의생명소재공학전공) ;
  • 이보형 (강원대학교 의생명소재공학전공) ;
  • 윤보라 (강원대학교 의생명소재공학전공) ;
  • 이지우 (강원대학교 의생명소재공학전공) ;
  • 이현용 (서원대학교 차학과(식품공학과)) ;
  • 박동식 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 정희철 ((주)뉴트리) ;
  • 정재윤 ((주)뉴트리) ;
  • 마충제 (강원대학교 의생명소재공학전공)
  • Received : 2013.01.04
  • Accepted : 2013.03.04
  • Published : 2013.03.31


Alzheimer's disease (AD), most common form of dementia is characterized that memory deficit and loss of cognitive function. The Codonopsis lanceolata (C.lanceolata) was treated by high hydrostatic pressure process and fermentation. This study was evaluated cognitive enhancing effect C.lanceolata extract by high hydrostatic pressure process and fermentation and compared with common C.lanceolata extract using Morris water maze and passive avoidance test. And their neuroprotective effect on glutamate induced oxidative stress in HT22 cell was investigated by MTT assay. High hydrostatic pressure process and fermented C.lanceolata extract (HFCE) and common C.lanceolata extract (CCE) (100 and 300 mg/kg) were administered to mice. Results showed HFCE enhanced cognitive function than CCE as shown by decrease in escape latency time. HFCE increased the latency time of the passive avoidance test compared to CCE. Furthermore, HFCE showed significant neuroprotective effect against glutamate cytotoxicity in HT22 cells. These results indicate that high hydrostatic pressure process and fermented more improve spatial cognitive ability of C. laanceolata.



Supported by : 농촌진흥청


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