- Volume 37 Issue 3
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Wound Healing Effect of Curcumin Gel for Transdermal Delivery
경피전달을 위한 커큐민 젤의 창상치유효과
- Kim, Jin (Department of Advanced Chemicals and Engineering, Chonnam National University) ;
- Kim, Man Jong (Department of Advanced Chemicals and Engineering, Chonnam National University) ;
- Lee, Ki-Young (Faculty of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University)
- Received : 2012.12.26
- Accepted : 2013.01.08
- Published : 2013.05.25
The aim of this study was to investigate the effect of trasdermal delivery of the curcumin gel on healing of the rats' dorsum wounds. Carbopol 934 and propylene glycol were used to prepare gels containing 1% curcumin. Curcumin gel was evaluated for various properties such as antioxidant, cell viability, anti-inflammatory, in vivo wound healing. The free radical scavenging activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) was 50% at 12.5 ppm concentration. Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells by curcumin gel. In the curcumin gel-treated group, the re-epithelialization in wounds was significantly increased compared to the control group throughout the experimental period. These results suggested that curcumin may be helpful for the promotion of wound healing.
Supported by : 한국연구재단
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