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Wound Healing Effect of Curcumin Gel for Transdermal Delivery

경피전달을 위한 커큐민 젤의 창상치유효과

  • Kim, Jin (Department of Advanced Chemicals and Engineering, Chonnam National University) ;
  • Kim, Man Jong (Department of Advanced Chemicals and Engineering, Chonnam National University) ;
  • Lee, Ki-Young (Faculty of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University)
  • 김진 (전남대학교 신화학소재공학과) ;
  • 김만종 (전남대학교 신화학소재공학과) ;
  • 이기영 (전남대학교 응용화학공학부 & 촉매연구소)
  • Received : 2012.12.26
  • Accepted : 2013.01.08
  • Published : 2013.05.25

Abstract

The aim of this study was to investigate the effect of trasdermal delivery of the curcumin gel on healing of the rats' dorsum wounds. Carbopol 934 and propylene glycol were used to prepare gels containing 1% curcumin. Curcumin gel was evaluated for various properties such as antioxidant, cell viability, anti-inflammatory, in vivo wound healing. The free radical scavenging activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) was 50% at 12.5 ppm concentration. Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells by curcumin gel. In the curcumin gel-treated group, the re-epithelialization in wounds was significantly increased compared to the control group throughout the experimental period. These results suggested that curcumin may be helpful for the promotion of wound healing.

Acknowledgement

Supported by : 한국연구재단

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