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The Effect of Mulberry Leaf Extract on Blood biochemical parameters in White Rats Exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

상엽 물추출물이 다이옥신 유도 독성에 대한 흰쥐의 혈액 생화학지표에 미치는 영향

  • 이윤복 ((주)정식품 중앙연구소) ;
  • 배수정 (대전대학교 임상병리학과) ;
  • 이다경 (대전대학교 임상병리학과) ;
  • 박재승 (서해대학교 임상병리학과) ;
  • 박지원 (김천대학교 의료경영학과) ;
  • 김병원 (김천대학교 임상병리학과) ;
  • 황석연 (대전대학교 임상병리학과)
  • Received : 2012.10.19
  • Accepted : 2012.11.15
  • Published : 2013.01.31

Abstract

We investigated the effect of mulberry leaf extract (MLE) on blood biochemical parameters of white rats induced TCDD toxicity. Data were analyzed by One-way ANOVA and Post-Hoc Test. The numbers of leukocyte and platelet decreased by TCDD were increased dramatically after treated MLE (p<0.01). The concentration of calcium and magnesium decreased by TT were increased by MLE and shown a statistical significance (p<0.01) but the concentration of phosphorus increased by TT was decreased by MLE. In the test of parameters related to renal function, only the concentration of uric acid in the MLE group was decreased than it in TT group and shown a statistical significance (p<0.01). Also the concentration of blood glucose and the activity of amylase and lipase increased by TT were decreased after treated MLE and shown a statistical significance (p<0.01), and MLE had an control effect for elevating blood glucose. In the test of parameters related to liver function, the acticity of AST, ALT and ALP increased by TT was decreased after treated MLE and shown a statistical significance (p<0.01), and MLE had an improving effect for liver function. In the case of total cholesterol (T,cho), triglyceride( TG), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) related to lipid metabolism, the amount of T,cho, TG, LDL-C increased by TT were decreased after treated MLE and shown a statistical significance (p<0.01), and MLE had an ability of anti-hyperlipidemia. From these results, we concluded that MLE could mollified TCDD toxicity in white rats exposed to TCDD.

Keywords

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD);mulberry leaf water extract;blood glucose;hyperlipidemia;blood biochemical parameters

Acknowledgement

Supported by : 농림수산식품부