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Investigation of the Correlation between Seoul Neuropsychological Screening Battery Scores and the Gray Matter Volume after Correction of Covariates of the Age, Gender, and Genotypes in Patients with AD and MCI

알츠하이머 치매 및 경도인지기능장애 환자에서 나이, 성별, 유전자형을 고려한 뇌 회백질 부피와 표준신경심리검사와의 상관관계 연구

  • Lee, Seung-Yeon (Department of Medicine, School of Medicine, Kyung Hee University) ;
  • Yoon, Soo-Young (Department of Medicine, School of Medicine, Kyung Hee University) ;
  • Kim, Min-Ji (Department of Radiology, Kyung Hee University Hospital at Gangdong) ;
  • Rhee, Hak Young (Department of Neurology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University) ;
  • Ryu, Chang-Woo (Department of Radiology, Kyung Hee University Hospital at Gangdong) ;
  • Jahng, Geon-Ho (Department of Radiology, Kyung Hee University Hospital at Gangdong)
  • 이승연 (경희대학교 의학전문대학원 의학과) ;
  • 윤수영 (경희대학교 의학전문대학원 의학과) ;
  • 김민지 (경희대학교 강동경희대학교병원 영상의학과) ;
  • 이학영 (경희대학교 의과대학 강동경희대학교병원 신경과) ;
  • 류창우 (경희대학교 강동경희대학교병원 영상의학과) ;
  • 장건호 (경희대학교 강동경희대학교병원 영상의학과)
  • Received : 2013.07.29
  • Accepted : 2013.09.09
  • Published : 2013.12.27

Abstract

Purpose : To investigate the correlations between Seoul Neuropsychological Screening Battery (SNSB) scores and the gray matter volumes (GMV) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) and cognitively normal (CN) elderly subjects with correcting the genotypes. Materials and Methods: Total 75 subjects were enrolled with 25 subjects for each group. The apolipoprotein E (APOE) epsilon genotypes, SNSB scores, and the 3D T1-weighted images were obtained from all subjects. Correlations between SNSB scores and GMV were investigated with the multiple regression method for each subject group using both voxel-based and region-of-interest-based analyses with covariates of age, gender, and the genotype. Results: In the AD group, Rey Complex Figure Test (RCFT) delayed recall scores were positively correlated with GMV. In the MCI group, Seoul Verbal Learning Test (SVLT) scores were positively correlated with GMV. In the CN group, GMV negatively correlated with Boston Naming Test (K-BNT) scores and Mini-Mental State Examimation (K-MMSE) scores, but positively correlated with RCFT scores. Conclusion: When we used covariates of age, gender, and the genotype, we found statistically significant correlations between some SNSB scores and GMV at some brain regions. It may be necessary to further investigate a longitudinal study to understand the correlation.

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