DOI QR코드

DOI QR Code

Lack of any Association between Blood Groups and Lung Cancer, Independent of Histology

  • Oguz, Arzu (Medical Oncology Clinic, Kayseri Education and Research Hospital) ;
  • Unal, Dilek (Radiation Oncology Clinic, Kayseri Education and Research Hospital) ;
  • Tasdemir, Arzu (Pathology Clinic, Kayseri Education and Research Hospital) ;
  • Karahan, Samet (Internal Medicine Clinic, Kayseri Education and Research Hospital) ;
  • Aykas, Fatma (Internal Medicine Clinic, Kayseri Education and Research Hospital) ;
  • Mutlu, Hasan (Medical Oncology Clinic, Acibadem Hospital) ;
  • Cihan, Yasemin Benderli (Radiation Oncology Clinic, Acibadem Hospital) ;
  • Kanbay, Mehmet (Nephrology Clinic, Istanbul Medeniyet University)
  • Published : 2013.01.31

Abstract

Introduction: Lung cancer, the leading cause of cancer deaths, is divided into 2 main classes based on its biology, therapy and prognosis: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Many cases are at an advanced stage at diagnosis, which is a major obstacle to improving outcomes. It is important to define the high risk group patients for early diagnosis and chance of cure. Blood group antigens are chemical components on erythrocyte membranes but they are also expressed on a variety of epithelial cells. Links between ABO blood groups with benign or malignant diseases, such as gastric and pancreas cancers, have been observed for a long time. In this study, we aimed to investigate any possible relationship between lung cancer histological subtypes and ABO-Rh blood groups. Materials and Methods: The files of 307 pathologically confirmed lung cancer patients were reviewed retrospectively. Cases with a serologically determined blood group and Rh factor were included and those with a history of another primary cancer were excluded, leaving a total of 221. The distribution of blood groups of the lung cancer patients were compared with the distribution of blood groups of healthy donors admitted to the Turkish Red Crescent Blood Service in our city in the year 2012. Results: There was no significant difference between patients with lung cancer of either type and the control group in terms of distribution of ABO blood groups and Rh factor (p: 0.073). There was also no relationship with non small cell cancer histological subtypes. Conclusions: In this study, we found no relationship between the ABO-Rhesus blood groups and NSCLC and SCLC groups. To our knowledge this is the first analysis of ABO blood groups in SCLC patients.

References

  1. Greer JB, Yazer MH, Raval JS, et al., 2010. Significant association between abo blood group and pancreatic cancer. World J Gastroenterol, 16, 5588-91. https://doi.org/10.3748/wjg.v16.i44.5588
  2. Hosoi E (2008). Biological and clinical aspects of ABO blood group system. J Med Invest, 55, 174-82. https://doi.org/10.2152/jmi.55.174
  3. Iodice S, Maisonneuve P, Botteri E., 2010. AB0 blood group and cancer. Eur J Cancer, 46, 3345-50. https://doi.org/10.1016/j.ejca.2010.08.009
  4. Landsteiner K (1900). Zur Kenntnis der antifermentativen, lytischen and agglutinierenden Wirkungen des Blutserums und der Lymphe. Zentralbl Bakteriol, 27, 357-62.
  5. Lee JS, Ro JY, Sahin AA, et al (1991). Expression of blood group antigen A: a favourable prognostic factor in non-small cell lung cancer. N Engl J Med, 324, 1084-90. https://doi.org/10.1056/NEJM199104183241603
  6. Lee JS, Hong WK (1992). Prognostic factors in lung cancer. N Engl J Med, 327,47-8. https://doi.org/10.1056/NEJM199207023270110
  7. Miyake M, Taki T, Hitomi S., 1992. Correlation of expression of H/Ley/Leb antigens with survival in patients with carcinoma of the lung. N Engl J Med, 327, 14-8. https://doi.org/10.1056/NEJM199207023270103
  8. Reid ME, Mohandas N (2004). Red blood cell blood group antigens: structure and function. Semin Hematol, 41, 93-117.
  9. Roberts TE, Hasleton P, Swindell R., 1988. Blood groups and lung cancer. Br J Cancer, 58, 278. https://doi.org/10.1038/bjc.1988.201
  10. Siegel R, Ward E, Brawley O., 2011. Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011, 212-36.
  11. Suadicani P, Hein HO, Gyntelberg F (2007). ABO phenotypes and inflammation related predictors of lung cancer mortality: the Copenhagen Male Study-a-16 year follow up. Eur Respir J, 30, 13-20. https://doi.org/10.1183/09031936.00062506
  12. Urun Y, Utkan G, Yalcin S, et al., 2012. Lack of any relationship between ABO and Rh blood groups and clinicopathological features in patients with gastrointestinal tromal tumors: Turkish Oncology Group. Asian Pac J Cancer Prev,13, 4129-31. https://doi.org/10.7314/APJCP.2012.13.8.4129
  13. Wolpin BM, Chan AT, Hartge P, et al., 2009. ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst, 101, 424-31. https://doi.org/10.1093/jnci/djp020
  14. Wolpin BM, Kraft P, Gross M, et al., 2010. Pancreatic cancer risk and ABO blood group alleles: Results from the Pancreatic Cancer Cohort Consortium. Cancer Res, 70, 1015-23. https://doi.org/10.1158/0008-5472.CAN-09-2993
  15. Zmijewski CM (1978). Immunohematology 3rd ed.: Appleton Century Crofts New York.
  16. Aberle DR, Adams AM, Berg CD, et al., 2011. Reduced lung cancer mortality with low-dose computed tomography screening. N Engl J Med, 365395-409.
  17. Aird I, Bentall HH, Roberts JA (1953). A relationship between cancer of stomach and the abo blood groups. Br J Med J, 1, 799-801. https://doi.org/10.1136/bmj.1.4814.799
  18. Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, et al., 2009. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet, 41, 986-90. https://doi.org/10.1038/ng.429
  19. Ashley DJB (1969). Blood groups and lung cancer. J Med Genet, 6, 183-6. https://doi.org/10.1136/jmg.6.2.183
  20. Dall’olio F (1996). Protein glycosylation in cancer biology: An overview. Clin Mol Pathol, 49, 126-35. https://doi.org/10.1136/mp.49.3.M126
  21. Edgren G, Hjalgrim H, Rostgaard K, et al., 2010. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol, 172, 1280-5. https://doi.org/10.1093/aje/kwq299
  22. Finkelstein DM, Ettinger DS, Ruckdeschel JC (1986). Long-term survivors in metastatic non-small cell lung cancer: an Eastern Cooperative Oncology Group Study. J Clin Oncol, 4, 702-9.
  23. Graziano SL, Tatum AH, Gonchoroff NJ., 1997. Blood group antigen A and flow cytometric analysis in resected early stage non-small cell lung cancer. Clin Cancer Res, 3, 87-93.

Cited by

  1. Does Sunlight Exposure Improve Survival in Patients with Non-small Cell Lung Cancer? vol.14, pp.11, 2013, https://doi.org/10.7314/APJCP.2013.14.11.6301
  2. Serum IL-33 as a Diagnostic and Prognostic Marker in Non-small Cell Lung Cancer vol.14, pp.4, 2013, https://doi.org/10.7314/APJCP.2013.14.4.2563
  3. ABO Blood Groups are Not Associated with Treatment Response and Prognosis in Patients with Local Advanced Non-Small Cell Lung Cancer vol.14, pp.6, 2013, https://doi.org/10.7314/APJCP.2013.14.6.3945
  4. Clinical Observations on the Association Between Diagnosis of Lung Cancer and Serum Tumor Markers in Combination vol.14, pp.7, 2013, https://doi.org/10.7314/APJCP.2013.14.7.4369
  5. Timing of Thoracic Radiotherapy in Limited Stage Small Cell Lung Cancer: Results of Early Versus Late Irradiation from a Single Institution in Turkey vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6263
  6. Serum interleukin-17 as a diagnostic and prognostic marker for non-small cell lung cancer vol.19, pp.4, 2014, https://doi.org/10.3109/1354750X.2014.908954
  7. The diagnostic and prognostic value of serum human kallikrein-related peptidases 11 in non-small cell lung cancer vol.35, pp.6, 2014, https://doi.org/10.1007/s13277-014-1674-x
  8. Hemostasis, cancer, and ABO blood group: the most recent evidence of association vol.38, pp.2, 2014, https://doi.org/10.1007/s11239-013-1027-4
  9. Clinical Evaluation of Tumor Markers for Diagnosis in Patients with Non-small Cell Lung Cancer in China vol.16, pp.12, 2015, https://doi.org/10.7314/APJCP.2015.16.12.4891
  10. Rhesus CE expression on patient red blood cells is an independent prognostic factor for adenocarcinoma of the lung pp.17526981, 2017, https://doi.org/10.1111/crj.12638
  11. Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS-13 in patients with lung cancer vol.14, pp.3, 2017, https://doi.org/10.3892/ol.2017.6619
  12. The Prevalence of Rhesus-Negative Blood Group Among Patient With Small Cell Lung Cancer and Analysis of Its Effect on Overall Survival vol.8, pp.2234-943X, 2018, https://doi.org/10.3389/fonc.2018.00358