- Volume 14 Issue 1
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The miR-146a rs2910164 G > C Polymorphism and Susceptibility to Digestive Cancer in Chinese
- Wu, Dong (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine) ;
- Wang, Fan (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine) ;
- Dai, Wei-Qi (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine) ;
- He, Lei (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine) ;
- Lu, Jie (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine) ;
- Xu, Ling (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine) ;
- Guo, Chuan-Yong (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine)
- Published : 2013.01.31
Background: Several studies have reported the role of the miR-146a rs2910164 G > C polymorphism as a susceptibility factor for several digestive cancers. However, the results have been controversial. Therefore, we conducted the present meta-analysis to obtain the most reliable estimate of the association. Methods: PubMed, Embase and Web of Science databases were searched. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between miR-146a rs2910164 G > C polymorphism and digestive cancer risk. A total of four eligible studies including 3,447 cases and 5,041 controls based on the search criteria were included. Results: We observed that miR-146a rs2910164 G > C polymorphism was not significantly correlated with digestive cancer risks when all studies were pooled into the meta-analysis. While we found that miR-146a rs2910164 polymorphism was not associated with gastric cancer, it was significantly linked with hepatocellular cancer risk (the homozygote codominant model: OR = 1.40, 95% CI = 1.04-1.87). In the stratified analysis by ethnicity, significant associations were observed in Chinese population for the allele contrast model (OR = 1.25; 95% CI = 1.12-1.38), for the homozygote codominant model (OR = 1.62; 95% CI = 1.28-2.04), and for the recessive model (OR = 1.38; 95% CI = 1.16-1.64). However, studies with Asian groups presented no significant association for all genetic models. Conclusions: This meta-analysis suggests that the miR-146a rs2910164 G > C polymorphism is a low-penetrant risk factor for digestive cancers in Chinese.
Supported by : National Natural Science Foundation of China
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