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Effects of ethanolic extract of Ulmus davidiana Root on Lipid Metabolism in High-Fat Diet Fed Mice

느릅나무 뿌리 에탄올 추출물이 고지방 식이를 섭취한 마우스의 지질대사에 미치는 영향

  • Um, Min Young (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Choi, Won Hee (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Ahn, Jiyun (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Ha, Tae Youl (Division of Metabolism and Functionality Research, Korea Food Research Institute)
  • 엄민영 (한국식품연구원 대사기능연구본부) ;
  • 최원희 (한국식품연구원 대사기능연구본부) ;
  • 안지윤 (한국식품연구원 대사기능연구본부) ;
  • 하태열 (한국식품연구원 대사기능연구본부)
  • Received : 2012.10.23
  • Accepted : 2013.01.24
  • Published : 2013.03.31

Abstract

This study was performed to investigate the effects of ethanolic extract of Ulmus davidiana root (UE) on lipid metabolism in mice fed a high-fat diet (HF) for 7 weeks. Forty male ICR mice were randomly divided into four groups; normal diet group (N), high-fat diet group (HF), HF with 0.5% UE (HF-L) and 1% UE (HF-H) group. Body weight, body weight gain, and liver weight in the HF group was significantly higher than in the N group, while those of the HF-L and HF-H group were unchanged. UE improved HF-induced dyslipidemia by reducing serum triglyceride, total cholesterol, and the atherogenic index. There was no difference in serum HDL-cholesterol among experimental groups. However, the HDL-cholesterol/total cholesterol ratio was significantly increased in the HF-L and HF-H group. Histological analysis showed that HF-fed mice developed hepatocellular microvesicular vacuolation as a result of fat accumulation. These changes were attenuated by 1% UE supplementation. In addition, hepatic triglyceride and cholesterol levels in the HF-H group significantly reduced. Taken together, these results demonstrated that lipid levels in the blood and liver were reduced by UE, suggesting that it might be beneficial for the prevention and treatment of hyperlipidemia and fatty liver.

Acknowledgement

Supported by : 지식경제부

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