Transition over 35 Years in the Incidence Rates of Primary Central Nervous System Tumors in Shanghai, China and Histological Subtyping Based on a Single Center Experience Spanning 60 Years

  • Shen, Fang (Department of Neurosurgery, Huashan Hospital, Fudan University) ;
  • Wu, Chun-Xiao (Department of Cancer Control and Prevention, Shanghai Municipal Center for Disease Prevention and Control) ;
  • Yao, Yu (Department of Neurosurgery, Huashan Hospital, Fudan University) ;
  • Peng, Peng (Department of Cancer Control and Prevention, Shanghai Municipal Center for Disease Prevention and Control) ;
  • Qin, Zhi-Yong (Department of Neurosurgery, Huashan Hospital, Fudan University) ;
  • Wang, Yin (Department of Neuropathology, Institute of Neurology, Huashan Hospital, Fudan University) ;
  • Zheng, Ying (Department of Cancer Control and Prevention, Shanghai Municipal Center for Disease Prevention and Control) ;
  • Zhou, Liang-Fu (Department of Neurosurgery, Huashan Hospital, Fudan University)
  • Published : 2013.12.31


Background: Only few epidemiological data on primary central nervous system (CNS) tumors in Shanghai have been reported. Methods: All cases of primary CNS tumors that were registered at Center for Disease Control and Prevention (CDC) were collected (1973-2007: urban Shanghai; 2003-2007: whole Shanghai city). Trends were analyzed using joinpoint analysis and rates were stratified by age, gender and region. Histological data were collected from both CDC and Huashan Hospital. Results: From 1973 to 2007, the five-year average incidence rate in urban Shanghai increased in both genders, especially in the elderly population. Joinpoint analysis showed the age-adjusted incidence rate for males increased first but then plateaued, whilst rates for females continued increasing over the 35 years. For the five-year status quo (2003-2007), rural had a higher age-adjusted incidence rate than urban populations, and females higher than males, especially those with advanced age. According to CDC (2003-2007) and Huashan Hospital (1951-2011), the two most common histological subtypes were neuroepithelial tumors (with male predominance) and meningiomas (with female predominance). Conclusions: In Shanghai, a steadily increased incidence rate of primary CNS tumors was observed in general, and in the elderly and female population in particular.


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